医学临床研究
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医学临床研究  2023, Vol. 40 Issue (2): 205-208    DOI: 10.3969/j.issn.1671-7171.2023.02.013
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口腔鳞癌患者癌组织中上皮糖蛋白40的表达与临床病理特征及预后的关系
孙芹芹1, 肖金庆1, 朱玉娟2
1.山东省立第三医院口腔科,山东 济南 250031;
2.泰安市中医二院口腔科,山东 泰安 271000
Expression of EGP40 in Oral Squamous Cell Carcinoma and Its Relationship with Clinicopathological Features and Prognosis
SUN Qin-qin, XIAO Jin-qing, ZHU Yu-juan
Department of Stomatology,Shandong Provincial Third Hospital,Jinan Shandong 250031
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摘要 【目的】探讨上皮糖蛋白40(EGP40)在口腔鳞癌(OSCC)组织中的表达及其与临床病理特征及预后的关系。【方法】两院收治的88例OSCC患者均行OSCC根治手术,术后随访3年。采用免疫组化法检测患者癌组织、癌旁组织中EGP40表达情况,分析癌组织中EGP40蛋白表达与OSCC患者病理特征参数的关系,分析OSCC患者术后复发、转移的影响因素及EGP40表达与术后复发、转移的关系。【结果】OSCC患者癌组织中EGP40阳性表达率高于癌旁组织(P<0.05)。Ⅲ~Ⅳ期、浸润深度≥5 mm、低分化、累及脉管、有淋巴结转移患者癌组织中EGP40阳性表达率分别高于Ⅰ~Ⅱ期、浸润深度<5 mm、中高分化、未累及脉管、无淋巴结转移者(P<0.05)。截至随访结束,9例失访。Cox回归分析显示,分期、分化程度、淋巴结转移及EGP40阳性是影响OSCC患者术后复发或转移的独立因素(P<0.05)。EGP40阴性表达患者的无病生存曲线优于EGP40阳性表达患者,且差异有统计学意义(P<0.05)。【结论】OSCC患者癌组织中EGP40异常高表达,EGP40表达与患者病理情况、预后有关,EGP40阳性表达患者术后复发或转移风险高。
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孙芹芹
肖金庆
朱玉娟
关键词 口腔肿瘤/病理学癌,鳞状细胞/病理学免疫组织化学预后    
Abstract:【Objective】To investigate the expression of epithelial glycoprotein 40 (EGP40) in oral squamous cell carcinoma (OSCC) carcinoma and its relationship with clinicopathological features and prognosis. 【Methods】A total of 88 OSCC patients admitted to the hospital underwent radical surgery for OSCC and were followed up for 3 years. Immunohistochemistry was used to detect the expression of EGP40 protein in cancer and adjacent tissues. The relationship between EGP40 protein expression in cancer tissue and pathological parameters of patients was analyzed. The influence factors of postoperative recurrence and metastasis in OSCC patients were investigated; And the relationship of EGP40 expression with postoperative recurrence and metastasis were analyzed. 【Results】The positive expression rate of EGP40 in cancer tissues of OSCC patients was higher than that in adjacent tissues (P<0.05). The expression rate of EGP40 protein in cancer tissues of patients with stage Ⅲ-Ⅳ,invasion depth ≥5 mm,poorly differentiated,vascular involvement and lymph node metastasis was higher than that of stage Ⅰ-Ⅱ,invasion depth <5 mm,moderately and well differentiated,no vascular involvement and no lymph node metastasis (P<0.05). Cox regression analysis showed that stage,degree of differentiation,lymph node metastasis and EGP40 positive were independent factors affecting postoperative recurrence and metastasis in OSCC patients (P<0.05). The disease-free survival curve of patients with negative EGP40 expression was better than that of patients with positive EGP40 expression; And the difference was statistically significant (P<0.05). 【Conclusion】EGP40 is abnormally high in cancer tissue of OSCC patients. EGP40 expression is related to the pathological condition and prognosis of patients. Patients with positive EGP40 expression have a high risk of recurrence and metastasis after surgery.
Key wordsMouth Neoplasms/PA    Carcinoma, Squamous Cell/PA    Immunohistochemistry    Prognosis
收稿日期: 2022-04-22     
中图分类号:  R739.8  
引用本文:   
孙芹芹, 肖金庆, 朱玉娟. 口腔鳞癌患者癌组织中上皮糖蛋白40的表达与临床病理特征及预后的关系[J]. 医学临床研究, 2023, 40(2): 205-208.
SUN Qin-qin, XIAO Jin-qing, ZHU Yu-juan. Expression of EGP40 in Oral Squamous Cell Carcinoma and Its Relationship with Clinicopathological Features and Prognosis. JOURNAL OF CLINICAL RESEARCH, 2023, 40(2): 205-208.
链接本文:  
http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2023.02.013     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2023/V40/I2/205
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