血清NF-κB、Nrf2水平对2型糖尿病肾病患者预后的预测价值

doi:10.3969/j.issn.1671-7171.2023.12.034

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摘要【目的】探讨血清核因子-κB(NF-κB)、核因子E2相关因子(Nrf2)水平对2型糖尿病肾病患者预后的预测价值。【方法】回顾性分析2020年4月至2022年4月陕西省核工业二一五医院收治的118例2型糖尿病肾病患者的临床资料,根据患者预后情况分为预后不佳组(肾功能衰竭、尿毒症或死亡,n=48)和预后良好组(n=70)。分析2型糖尿病肾病患者预后的影响因素及NF-κB、Nrf2对2型糖尿病肾病患者预后的预测价值。【结果】预后不佳组NF-κB、血肌酐(Scr)、尿蛋白排泄率(UAER)水平均高于预后良好组,Nrf2、肾小球滤过率(eGFR)均低于预后良好组(P<0.05)。Logistic分析结果显示:NF-κB升高、Scr升高、UAER升高、Nrf2降低、eGFR降低均是2型糖尿病肾病患者预后不佳的危险因素(P<0.05)。受试者工作特征(ROC)曲线分析显示:血清NF-κB、Nrf2及其联合预测2型糖尿病肾病患者预后的曲线下面积(AUC)分别为0.713、0.706、0.801。【结论】血清NF-κB联合Nrf2对2型糖尿病肾病患者预后的预测效能良好。

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	张勇
	王新磊

关键词 ：糖尿病,2型/并发症, 糖尿病肾病/并发症, 转录因子/血液, NF-κB/血液

Abstract：【Objective】To explore the prognostic value of serum levels of nuclear factor-κB (NF-κB) and nuclear factor E2 related factor (Nrf2) in patients with type 2 diabetes nephropathy.【Methods】The clinical data of 118 patients with type 2 diabetes nephropathy admitted to the NO.215 Hospital of Shaanxi Nuclear Industry from April 2020 to April 2022 were retrospectively analyzed. According to the prognosis of patients, they were divided into poor prognosis group (renal failure, uremia or death, n=48) and good prognosis group (n=70). The prognostic factors of type 2 diabetes nephropathy patients and the predictive value of NF-κB and Nrf2 on the prognosis of type 2 diabetes nephropathy patients were analyzed.【Results】The levels of NF-κB, serum creatinine (Scr), and urinary protein excretion rate (UAER) in the poor prognosis group were higher than those in the good prognosis group, while Nrf2 and glomerular filtration rate (eGFR) were lower than those in the good prognosis group (P<0.05). Logistic analysis showed that the increase of NF-κB, Scr, UAER, Nrf2 and eGFR were all risk factors for poor prognosis of type 2 diabetes nephropathy patients (P<0.05). The analysis of ROC curve of subjects showed that the area under the curve (AUC) of serum NF-κB, Nrf2 and their combination to predict the prognosis of type 2 diabetes nephropathy patients were 0.713, 0.706 and 0.801, respectively. 【Conclusion】The combination of serum NF-κB and Nrf2 is effective in predicting the prognosis of patients with type 2 diabetes nephropathy.

Key words： Diabetes Mellitus, Type 2/CO Diabetic Nephropathies/CO Transcription Factors/BL NF-kappa B/BL

收稿日期: 2023-06-26

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R587.1

通讯作者: *E-mail:wxlmedicine@163.com

引用本文:

张勇, 王新磊. 血清NF-κB、Nrf2水平对2型糖尿病肾病患者预后的预测价值[J]. 医学临床研究, 2023, 40(12): 1940-1942.
ZHANG Yong,WANG Xinlei. Prognostic Value of Serum NF-κB and Nrf2 Levels in Type 2 Diabetes Nephropathy. JOURNAL OF CLINICAL RESEARCH, 2023, 40(12): 1940-1942.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2023.12.034 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2023/V40/I12/1940