长沙地区AR及AR伴AIDS患者变应原检测结果的比较

doi:10.3969/j.issn.1671-7171.2022.04.003

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摘要【目的】比较长沙地区过敏性鼻炎(AR)及AR伴艾滋病(AIDS)患者变应原的检测结果。【方法】132例患者,根据诊断不同分为单纯AR组(A组)、AR伴AIDS组(B组)。比较两组患者18种常见变应原血清特异性免疫球蛋白E(sIgE)阳性水平、分布差异、致敏程度、致敏原种类以及与CD4⁺T淋巴细胞计数的关系。【结果】A组、B组患者常见的吸入变应原是混合草、树花粉、户尘螨、粉尘螨、霉菌组合;两组患者常见的食入性变应原是虾、蟹、牛肉、羊肉。A组患者混合草的阳性检出率及粉尘螨致敏强度较B组高,两组之间比较,差异有统计学意义(P<0.05);B组患者坚果组合的阳性检出率较A组高,两组之间比较,差异有统计学意义(P<0.05)。两组患者血清sIgE阳性检出率比较,差异无统计学意义(P>0.05);两组患者组内变应原阳性种类数比较差异具有统计学意义(P<0.05),且均以致敏原种类数≥4种为主;B组不同CD4⁺T淋巴细胞计数水平的患者变应原sIgE阳性检出率比较,差异具有统计学意义(P<0.05)。【结论】AR患者与AR伴AIDS两组患者血清变应原sIgE阳性水平、分布差异、致敏程度具有相似性,且均以多重过敏为主;AR伴AIDS患者CD4⁺T淋巴细胞计数水平较低者血清变应原sIgE阳性检出率较高。

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	申黎黎
	张俊杰
	李殷

关键词 ：鼻炎,过敏性, 获得性免疫缺陷综合征, 变应原

Abstract：【Objective】To investigate the expression level and significance of serum CD4⁺T lymphocytes and specific IgE (sIgE) in patients with allergic rhinitis (AR) and acquiredimmunodeficiency syndrome (AIDS).【Methods】 A total of 132 cases were divided into the simple AR group (group A) and AR with AIDS group (group B) according to the diagnosis.The sIgE positive level, distribution difference, degree of sensitization, type of sensitization and the CD4⁺T lymphocyte count of 18 common allergens in the two groups were compared.【Results】Common inhaled allergens in group A and B were mixed grass, tree pollen, house dust mite, dust mite and mold combination. The common ingestion allergens in the two groups were shrimp, crab , beef and mutton.The positive detection rate and dust mite sensitization intensity of mixed grass in group A were higher than those in group B, and the difference between the two groups was statistically significant (P<0.05).The positive detection rate of nut combination in group B was higher than that in group A, and the difference between the two groups was statistically significant (P<0.05).There was no significant difference in the positive rate of serum sIgE between the two groups (P>0.05).There was statistically significant difference in the number of allergen positive species between the two groups (P<0.05), and the number of allergen positive species in both groups was ≥4. There was statistical significance in the positive rate of sIgE in group B with different CD4⁺T lymphocyte count levels in the AR and AIDS group (P<0.05).【Conclusion】 The positive level, distribution differences and sensitization degrees of serum allergen sIgE were similar between the two groups.The positive rate of serum allergen sIgE was higher in patients with lower CD4⁺T lymphocyte count.

Key words： Rhinitis, Allergic Acquired Immunodeficiency Syndrome Allergens

收稿日期: 2021-11-08

中图分类号:

R765.213

基金资助:湖南省科技厅临床医疗技术创新引导项目(2020SK53003);南华大学研究生科研创新项目资助(203YXCO209)

通讯作者: **E-mail:junzhang1968@163.com;***E-mail:echo2072@163.com

引用本文:

申黎黎, 张俊杰, 李殷. 长沙地区AR及AR伴AIDS患者变应原检测结果的比较[J]. 医学临床研究, 2022, 39(4): 488-491.
SHEN Li-li, ZHANG Jun-jie, LI Yin. Comparative Analysis of Allergen Detection Results of Allergic Rhinitis (AR) and AR Patients with AIDS in Changsha Area. JOURNAL OF CLINICAL RESEARCH, 2022, 39(4): 488-491.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2022.04.003 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2022/V39/I4/488