Abstract：【Objective】To detect the expression and clinical significance of matrix metalloproteinase(MMP-3)、commonacute lymphoblastic leukemia antigen(CD10) and cell proliferation antigen Ki-67 in Triple-negative breast cancer(TNBC).【Methods】The manifestations of MMP-3、CD10 and Ki-67 were detected in 55 cases of TNBC,136 cases of Non-triple-negative breast cancer(N-TNBC) and 42 cases benign epithelial lesions of the breast by immunohistochemistry method.【Results】The overexpression rates of MMP-3、CD10 and Ki-67 protein in TNBC were 50.9％、45.5％and 56.4％,respectively, which were significantly higher than in N-TNBC(19.9%、21.3%、27.9%) and non-tumor tissues(9.5%、7.1%、0).The differences were statistically significant(P<0.05).The expression of MMP-3 was positively correlated with that of CD10 and Ki-67in TNBC(rs=0.312,P=0.020;rs=0.310,P=0.021,P<0.05). The positive rates of MMP-3、CD10 and Ki-67 overexpression were strongly associated with histological type of breast carcinoma, lymph node involvement and pN grades in TNBC (P<0.05).【Conclusion】High levels of MMP-3、CD10 and Ki-67 expression are significant in TNBC,which maybe play an importan trole in invasive event.Detection of the three markers together may contribute to the judgment of the grade of malignancy, the ability of tumor infiltration and the potency of metastasis.MMP-3、CD10 and Ki-67 proteins are closely associated with TNBC progression and subtypes,which may be a new potential prognostic biomarkers and therapeutic targets for TNBC.
[1] 张晓耀,康骅. 乳腺癌间质成纤维母细胞的生物学特性及研究现状[J].中国普外基础与临床杂志,2011, 18(2):212-215.
[2] 许良中, 杨文涛. 免疫组织化学反应结果的判断标准[J].中国癌症杂志, 1996,6(4):229-231.
[3] GNEMMI V,LEREY X,TRIBOULET J P,et al. Pancreatic metastases of renal cell carcinoma:a clinical pathological study of 11 cases with special emphasis on the usefulness of PAX2 and mesothelin for the distinction from primary ductal adenocarcinoma of the pancreas[J].Anal Quant Cytol Histol,2013,35(3):57-62.
[4] BISSELL M J,RADISKY D. Putting tumours in context[J].Nat Rev Cancer,2011,1(1):46-54.
[5] 周春辉,黄世章.胰腺癌细胞中CD10 mRNA的表达与肿瘤恶性程度及转移的关系[J].广东医学, 2011,32(12):55-57.
[6] FUJITA S, YAMAMOTO S, AKASU T, et al. Quantification of CD10 mRNA in colorectal cancer and relationship between mRNA expression and liver metastasis[J].Anticancer Res,2007,27(5A):7-11.
[7] 刘莉萍,孙凤玲,魏亚,等.表皮生长因子受体、p53、Ki-67在三阴型乳腺癌中的表达及其意义[J].肿瘤研究与临床,2013,25(10):669-671.
[8] 嵇浩,唐金海,赵建华.三阴乳腺癌Ki-67的表达与ER、PR及HER-2 的关系研究[J].徐州医学院学报,2015,35(12):921-924.
[9] 张莹,任战平,张芫,等.三阴与非三阴乳腺癌的临床病理特征及Ki-67 表达的对比研究[J].天津医药,2015,43(8):896-898.
[10] 刘焱,陈晨,林敏,等.MTDH在三阴型乳腺癌中的表达及与Ki-67、CD31的关系[J].中华临床医师杂志,2016,10(3):338-342.
2022, Vol. 39 
