Abstract：【Objective】 To investigate the pathogens, drug resistance and influencing factors of catheter-related bloodstream infections (CRBSI) in patients with maintenance hemodialysis (MHD). 【Methods】 A total of 96 MHD patients with CRBSI were enrolled in the study. Univariate analysis of risk factors for CRBSI, and multivariate analysis of independent risk factors for CRBSI in patients with MHD. Pathogens causing CRBSI and drug resistance to CRBSI pathogens were analyzed as well. 【Results】 Age, urea nitrogen (BUN), creatinine (SCr), globulin (GIO), albumin (ALB), hematocrit (HCT), hemoglobin level (HB), neutrophil percentage (NE), RBC and WBC were risk factors for CRBSI in patients with MHD (P<0.05). SCr, ALB, HB, NE, and RBC were independent risk factors for CRBSI in patients (P<0.05). A total of 82 pathogenic bacteria were isolated from 96 blood samples, with the isolation rate of 85.4%, of which Gram-negative bacteria (G-) accounted for 42.7% (35/82) and Gram-positive bacteria (G+) accounted for 57.3% (47/87). CRBSI pathogen resistance in Gram-positive bacteria did not show linezolid- and vancomycin-resistant strains. Staphylococcus epidermidis was highly resistant to erythromycin, tetracycline and oxacillin (≥40%); The methicillin-resistant Staphylococcus aureus showed very resistance to clindamycin, tetracycline, erythromycin and penicillin G. In Gram-negative bacteria, the resistance of Escherichia coli to sulfamethoxazole/trimethoprim, aztreonam, ceftriaxone, cefepime, and ceftazidime was 33.3%, while Pseudomonas aeruginosa was high resistance to sulfamethoxazole/trimethoprim, aztreonam and ceftriaxone, which was 100%.【Conclusion】 SCr, ALB, HB, NE and RBC are independent risk factors for CRBSI in patients with MHD. The drug resistance of various CRBSI pathogens is also high. Thus, it provides a basic knowledge for clinical prevention of CRBSI infections.
袁本林. MHD患者发生CRBSI的病原菌、耐药情况及影响因素分析[J]. 医学临床研究, 2020, 37(7): 1023-1025.
YUAN Ben-lin. Analysis of Pathogenic Bacteria, Drug Resistance and Influencing Factors of CRBSI in MHD Patients. JOURNAL OF CLINICAL RESEARCH, 2020, 37(7): 1023-1025.
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2020, Vol. 37 
