医学临床研究
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医学临床研究  2020, Vol. 37 Issue (10): 1471-1473    DOI: 10.3969/j.issn.1671-7171.2020.10.009
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NAG、β2-MG与慢性肾炎患者肾功能、炎症指标的相关性分析
段朝阳1, 高洁1, 韩锦1, 马晓桃1, 卢家美1, 王莉1**, 林燕2
1.西安交通大学第二附属医院肾病科,陕西 西安 710004;
2.陕西省人民医院内分泌糖尿病病院,陕西 西安 710068
Correlation Analysis of NAG and β2-MG with Renal Function and Inflammation Indexes in Patients with Chronic Nephritis
DUAN Chao-yang, GAO Jie, HAN Jin, et al
Department of Nephrology Second Affiliated Hospital of Xi'an Jiaotong University Xi'an, Shaanxi 710004
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摘要 【目的】 探讨慢性肾炎患者尿N-乙酰-β-D-葡萄糖苷酶(NAG)、β2-微球蛋白(β2-MG)水平及临床意义。【方法】 比较慢性肾炎患者和同期体检的健康成年人(对照组)尿NAG、β2-MG、血炎症因子超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、肾功能指标血肌酐(SCr)、尿素氮(BUN)和营养指标白蛋白(ALB)、血红蛋白(HGB)、红细胞计数(RBC)的差异,并分析慢性肾炎患者尿NAG、β2-MG与相关指标的相关性。【结果】 慢性肾炎组患者的NAG、β2-MG水平高于对照组(P<0.01);慢性肾炎组患者的hs-CRP、TNF-α和SCr、BUN水平高于对照组(P<0.01),RBC、HGB和ALB水平均低于对照组(P<0.01);慢性肾炎患者NAG、β2-MG与hs-CRP、TNF-α、SCr、BUN呈正相关,与RBC、HGB和ALB呈负相关。【结论】 慢性肾炎患者NAG、β2-MG水平较高,且与炎症因子、肾功能等指标相关。
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关键词 肾炎肾功能试验β2微球蛋白 /分析    
Abstract【Objective】 To explore the levels and clinical significance of NAG and beta 2-MG in patients with chronic nephritis. 【Methods】 The patients with chronic nephritis admitted in our hospital were selected as the observation group, and healthy adults who underwent physical examination were selected as the control group. The differences of urinary NAG, beta 2-MG, blood inflammatory factors (hs-CRP and TNF-a) and renal function indexes (SCr, BUN and ALB) between the two groups were. compared The correlation of urinary NAG and beta 2-MG with blood inflammatory factors and renal function indexes in patients with chronic nephritis was analyzed. 【Results】 The levels of NAG and beta 2-MG in chronic nephritis group which were higher than those in control group (P<0.01). Meanwhile the levels of hs-CRP, TNF-a,SCr and BUN in chronic nephritis group were higher than those in control group (P<0.01). However, the RBC, HGB and ALB levels in patients with chronic nephritis were lower than those in the control group (P<0.01). Both NAG and β2-MG levels in patients with chronic nephritis were positively correlated with levels of hs-CRP, TNF-α, SCr and BUN, while they were negatively correlated with levels of RBC, HGB and ALB. 【Conclusion】 The levels of NAG and beta 2-MG in patients with chronic nephritis are higher,which are correlated with inflammatory factors and renal function.
Key wordsNephritis    Kidney Function Tests    beta 2-Microglobulin/AN
收稿日期: 2019-07-28     
PACS:  R692.3  
基金资助:陕西省自然科学基础研究计划基金资助项目(2015JM8429)
通讯作者: **E-mail:lemonwine@126.com   
引用本文:   
段朝阳, 高洁, 韩锦, 马晓桃, 卢家美, 王莉, 林燕. NAG、β2-MG与慢性肾炎患者肾功能、炎症指标的相关性分析[J]. 医学临床研究, 2020, 37(10): 1471-1473.
DUAN Chao-yang, GAO Jie, HAN Jin, et al. Correlation Analysis of NAG and β2-MG with Renal Function and Inflammation Indexes in Patients with Chronic Nephritis. JOURNAL OF CLINICAL RESEARCH, 2020, 37(10): 1471-1473.
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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2020.10.009     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2020/V37/I10/1471
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