Abstract：【Objective】 To explore the levels and clinical significance of NAG and beta 2-MG in patients with chronic nephritis. 【Methods】 The patients with chronic nephritis admitted in our hospital were selected as the observation group, and healthy adults who underwent physical examination were selected as the control group. The differences of urinary NAG, beta 2-MG, blood inflammatory factors (hs-CRP and TNF-a) and renal function indexes (SCr, BUN and ALB) between the two groups were. compared The correlation of urinary NAG and beta 2-MG with blood inflammatory factors and renal function indexes in patients with chronic nephritis was analyzed. 【Results】 The levels of NAG and beta 2-MG in chronic nephritis group which were higher than those in control group (P<0.01). Meanwhile the levels of hs-CRP, TNF-a,SCr and BUN in chronic nephritis group were higher than those in control group (P<0.01). However, the RBC, HGB and ALB levels in patients with chronic nephritis were lower than those in the control group (P<0.01). Both NAG and β2-MG levels in patients with chronic nephritis were positively correlated with levels of hs-CRP, TNF-α, SCr and BUN, while they were negatively correlated with levels of RBC, HGB and ALB. 【Conclusion】 The levels of NAG and beta 2-MG in patients with chronic nephritis are higher,which are correlated with inflammatory factors and renal function.
段朝阳, 高洁, 韩锦, 马晓桃, 卢家美, 王莉, 林燕. NAG、β2-MG与慢性肾炎患者肾功能、炎症指标的相关性分析[J]. 医学临床研究, 2020, 37(10): 1471-1473.
DUAN Chao-yang, GAO Jie, HAN Jin, et al. Correlation Analysis of NAG and β2-MG with Renal Function and Inflammation Indexes in Patients with Chronic Nephritis. JOURNAL OF CLINICAL RESEARCH, 2020, 37(10): 1471-1473.
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2020, Vol. 37 
