Abstract：【Objective】 To investigate the relationship between the immunoglobulin M (IgM) deposition and the level of urinary protein and renal pathological changes in adult patients with IgA nephropathy (IgAN). 【Methods】 A total of 86 patients with IgAN who were admitted to our hospital from January 2012 to January 2017 were selected for the detection of IgM deposition by direct immunofluorescence. Patients were divided into the IgM positive group (n=40) and the IgM negative group(n=46). Total urinary protein, urinary protein excreation rate(UAER), urine β2 microglobulin (β2-MG), urinary α1 microglobulin (α1-MG), and Katafuchi were analyzed. 【Results】 The total urinary protein, UAER, and urine β2-MG in the IgM-positive group were higher than those in the IgM-negative group (P<0.05). There was no significant difference in urinary α1-MG levels between the two groups (P>0.05). Glomerular score, tubulointerstitial score, and total score in the IgM positive group were higher than those in the IgM negative group (P<0.05). There was no significant difference in renal vascular scores between the IgM positive group and the IgM negative group (P>0.05) Also, there was no significant difference in the Lee's grade between the IgM positive group and the IgM negative group (Z=-1.471, P=0.141>0.05).【Conclusion】 IgM deposition in patients with IgAN can promote further damage to renal function and aggravate the pathological damage of the kidney.
赵庆雨. IgA肾病患者IgM沉积表达与尿蛋白和肾脏病理变化的关系[J]. 医学临床研究, 2018, 35(9): 1709-1711.
ZHAO Qing-yu. Relationship between IgM Deposition and Pathological Changes of Urinary Protein and Kidney in Adult IgAN Patients. JOURNAL OF CLINICAL RESEARCH, 2018, 35(9): 1709-1711.
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2018, Vol. 35 
