Effects of Continuous Renal Replacement Therapy on Microinflammatory Status, Circulating Endothelial Cells, and Toll-Like Receptor 4 in Patients with Acute Renal Failure
DING Huiqiang, LI Na, CHEN Shaoliang, YUN Xuejiao
Blood Purification Center, Beichen Hospital of Beichen District, Tianjin 300499
Abstract：【Objective】 To investigate the effects of continuous renal replacement therapy (CRRT) on microinflammatory status, circulating endothelial cells (CECs), and Toll-like receptor 4 (TLR4) in patients with acute renal failure (ARF). 【Methods】 A total of 122 patients with ARF admitted to our hospital from January 2022 to January 2025 were randomly divided into an observation group and a control group, with 61 cases in each group. The observation group received CRRT, while the control group was treated with intermittent hemodialysis (HD). The microinflammatory markers [C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6)], renal function indices [blood urea nitrogen (BUN), serum creatinine (SCr)], levels of CECs and TLR4, and incidence of complications were compared between the two groups before treatment and after 2 weeks of treatment. 【Results】 After treatment, the levels of CRP, TNF-α, IL-6, BUN, SCr, CECs, and TLR4 in both groups were significantly lower than those before treatment, and the reductions were more pronounced in the observation group than in the control group (P<0.05). There was no statistically significant difference in the total incidence of complications between the two groups (P>0.05). 【Conclusion】 CRRT in patients with ARF can effectively alleviate the microinflammatory state, improve renal function, and reduce the levels of CECs and TLR4, with a favorable safety profile.
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2026, Vol. 43 
