氯普鲁卡因用于剖宫产腰硬联合麻醉中对患者炎症因子及疼痛程度的影响

doi:10.3969/j.issn.1671-7171.2025.07.027

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摘要【目的】探讨氯普鲁卡因用于剖宫产腰硬联合麻醉中对产妇炎症因子及疼痛程度的影响。【方法】在两院行剖宫产的100例产妇,随机分为观察组与对照组,每组50例。观察组在注射吗啡后10 min通过静脉注射3 %氯普鲁卡因5 mL,对照组在吗啡注射前10 min通过静脉注射生理盐水5 mL。比较两组术前及术后4 h、12 h、24 h、48 h炎症因子[白细胞介素-2(IL-2)、白细胞介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)]水平,比较两组术前及术后2 h、6 h、12 h、24 h、48 h视觉模拟评分法(VAS)及Ramsay镇静评分,比较两组不良反应发生情况。【结果】两组术后4 h、12 h、24 h、48 h 的IL-2水平明显低于术前(P<0.05),IL-10水平均明显高于术前(P<0.05),且观察组各时间点IL-2水平,术后12 h、24 h 的IL-10水平均明显低于对照组(P<0.05);观察组各时点TNF-α水平与术前比较,差异均无统计学意义(P>0.05),对照组术后4 h、12 h、24 h的TNF-α水平明显高于术前(P<0.05),观察组4 h、12 h、24 h的TNF-α水平明显低于对照组(P<0.05)。术后2 h、6 h、12 h、24 h、48 h,两组VAS评分和镇静评分均高于术前(P<0.05),但观察组术后各时点VAS评分低于对照组(P<0.05),各时点镇静评分高于对照组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。【结论】氯普鲁卡因用于剖宫产腰硬联合麻醉中,能够有效降低产妇炎症因子水平及疼痛程度,同时镇静效果较好,不良反应少,值得临床推广应用。

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	晏军
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关键词 ：剖宫产术, 普鲁卡因, 麻醉,脊椎, 麻醉,硬膜外, 炎症趋化因子类

Abstract：【Objective】This study aims to explore the effect of chloroprocaine combined epidural anesthesia in cesarean section on maternal inflammatory factors and pain intensity. 【Methods】A total of 100 pregnant women undergoing cesarean section from two hospitals were randomly divided into an observation group and a control group, with 50 cases in each. The observation group received an intravenous injection 5 mL of 3% chloroprocaine 10 minutes after morphine injection, while the control group received an intravenous injection 5 mL of 0.9% saline solution 10 minutes before morphine injection. The levels of inflammatory factors [interleukin-2(IL-2), interleukin-10(IL-10), tumor necrosis factor-α (TNF-α)] before surgery and 4, 12, 24, 48 hours after surgery were compared between the two groups, as well as the Visual Analog Scale (VAS) and Ramsay Sedation Scores before surgery and 2, 6, 12, 24, 48 hours after surgery, and the incidence of adverse reactions in both groups. 【Results】 The levels of IL-2 at 4, 12, 24, 48 hours after surgery in both groups were significantly lower than those before surgery (P<0.05), while the level of IL-10 was significantly higher than before surgery (P<0.05). IL-2 levels at all time points in the observation group were significantly lower and IL-10 levels of the observation group at 12, 24 hours after surgery were higher if compared to the control group (P<0.05). TNF-α levels in the observation group at all time points did not significantly change compared to before surgery (P>0.05), while in the control group, TNF-α levels at 4, 12, 24 hours after surgery were significantly higher than before surgery (P<0.05), and TNF-α levels at 4, 12, 24 hours in the observation group were lower than those in the control group (P<0.05). VAS scores and sedation scores of both groups at all time points after surgery increased compared to before surgery (P<0.05), with lower VAS scores and higher sedation scores in the observation group at all time points after surgery (P<0.05) if compared to those in the control group. There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】 In cesarean section, chloroprocaine combined with epidural anesthesia can effectively reduce maternal inflammatory factors and pain intensity, with good sedation effects and few adverse reactions, making it worthy of clinical promotion and application.

Key words： Cesarean Section Procaine Anesthesia, Spinal Anesthesia, Epidural Chemokines

收稿日期: 2023-09-20

中图分类号:

R719.8

通讯作者: ^*E-mail:749952013@qq.com

引用本文:

晏军, 呼延美. 氯普鲁卡因用于剖宫产腰硬联合麻醉中对患者炎症因子及疼痛程度的影响[J]. 医学临床研究, 2025, 42(7): 1199-1201.
YAN Jun, HU Yanmei. Effect of Chloroprocaine Combined Epidural Anesthesia in Cesarean Section on Inflammatory Factors and Pain Levels in Patients. JOURNAL OF CLINICAL RESEARCH, 2025, 42(7): 1199-1201.

链接本文:

http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2025.07.027 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2025/V42/I7/1199

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