Effects of Trans-Thoracic-Breast Approach Endoscopic Thyroidectomy versus Non-Inflating Trans-Axillary Approach Endoscopic Thyroidectomy on Inflammatory Factors, Endocrine Parameters, and Stress-Related Indicators in Patients with Unilateral Thyroid Cancer
LI Yayun, HUA Shenghe, WANG Xincheng, WANG Menglong
Department of General Surgery, Shuyang Hospital of Traditional Chinese Medicine, Shuyang Jiangsu 223600
Abstract：【Objective】 To compare the effects of trans-thoracic-breast approach endoscopic thyroidectomy versus non-inflating trans-axillary approach endoscopic thyroidectomy on inflammatory factors, endocrine parameters, and stress-related indicators in patients with unilateral thyroid cancer. 【Methods】 A total of 110 patients with unilateral thyroid carcinoma admitted to our hospital from January 2022 to January 2025 were selected. According to the surgical approach, they were divided into the control group (55 cases, endoscopic surgery via thoracic-breast approach) and the observation group (55 cases, non-inflating trans-axillary endoscopic surgery). The two groups were compared in terms of surgical indicators (operation time, intraoperative blood loss, number of lymph nodes dissected, postoperative drainage volume), white blood cell (WBC) count, C-reactive protein (CRP), interleukin-6 (IL-6), serum calcium, parathyroid hormone (PTH), cortisol (Cor), adrenaline (Adr), and complications (infection, subcutaneous effusion, transient hoarseness, neck discomfort). 【Results】 Intraoperative blood loss and postoperative drainage volume were lower in the observation group than in the control group (P<0.05). On postoperative day 1, levels of WBC count, CRP, and IL-6 in both groups were higher than their preoperative levels; furthermore, these levels were lower in the observation group than in the control group. The difference were statistically significant (P<0.05). Three days after surgery, there were no significant differences between the two groups in terms of serum calcium, PTH, Cor, and Adr levels (P>0.05). The complication rate in the observation group was 3.64% (2/55), which was lower than the 14.55% (8/55) in the control group (P<0.05). 【Conclusion】 Non-inflating trans-axillary endoscopic radical surgery for thyroid carcinoma is more effective in reducing intraoperative blood loss, alleviating inflammatory response and decreasing complications without increasing risks of endocrine and stress responses.
李亚芸, 华胜和, 王信成, 王梦龙. 经胸乳入路与经腋窝入路无充气腔镜甲状腺切除术对单侧甲状腺癌患者的炎症因子、内分泌指标与应激相关指标的影响[J]. 医学临床研究, 2026, 43(3): 418-421.
LI Yayun, HUA Shenghe, WANG Xincheng, WANG Menglong. Effects of Trans-Thoracic-Breast Approach Endoscopic Thyroidectomy versus Non-Inflating Trans-Axillary Approach Endoscopic Thyroidectomy on Inflammatory Factors, Endocrine Parameters, and Stress-Related Indicators in Patients with Unilateral Thyroid Cancer. JOURNAL OF CLINICAL RESEARCH, 2026, 43(3): 418-421.
2026, Vol. 43 
