Abstract：【Objective】 To investigate the anesthetic effect of esketamine combined with sevoflurane in patients undergoing oral surgery. 【Methods】 A total of 102 patients who underwent oral surgery from May 2021 to May 2024 were randomly divided into a control group and an observation group, with 51 cases in each group. The control group received esketamine anesthesia, while the observation group received esketamine combined with sevoflurane anesthesia. Surgical indicators, hemodynamics [heart rate (HR), mean arterial pressure (MAP)], sedation and analgesia levels [Ramsay sedation score, visual analogue scale (VAS)], and the incidence of adverse reactions were compared between the two groups. 【Results】 The onset time of anesthesia, extubation time, complete recovery time, and discharge time in the observation group were all shorter than those in the control group (P<0.05). The HR and MAP at 5 min after anesthesia induction (T1) and immediately after surgery (T2) in the observation group were lower than those in the control group (P<0.05). The Ramsay score at the time of leaving the operating room was higher in the observation group, while the VAS scores at 10 min and 30 min after recovery were lower than those in the control group (P<0.05). The total incidence of adverse reactions in the observation group was lower than that in the control group (P<0.05). 【Conclusion】 Esketamine combined with sevoflurane anesthesia in oral surgery can accelerate recovery, stabilize intraoperative hemodynamics, improve sedation, relieve postoperative pain, and reduce the incidence of adverse reactions.
2026, Vol. 43 
