Toll样受体4、核因子-κB、白介素-17与支原体肺炎患儿发生喘息的相关性<sup>*</sup>

doi:10.3969/j.issn.1671-7171.2025.07.002

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摘要【目的】探讨Toll样受体4(TLR4)、核因子-κB(NF-κB)、白介素-17(IL-17)水平与支原体肺炎(MP)患儿发生喘息的相关性。【方法】就诊于本院的82例MP患儿,根据患儿有无喘息的临床症状及听诊是否存在哮鸣音,将发生喘息患儿设为观察组,未发生喘息的患儿设为对照组。比较两组患儿的血清TLR4、NF-κB、IL-17水平。采用多因素Logistic回归分析TLR4、NF-κB、 IL-17水平与患儿发生喘息的相关性,采用受试者工作特征(ROC)曲线评估其对患儿发生喘息的预测价值。【结果】观察组患儿的TLR4、IL-17、NF-κB水平均显著高于对照组(P<0.05)。Logistic回归分析显示,TLR4、NF-κB、 IL-17水平与患儿的喘息发生风险呈正相关(均P<0.05)。ROC曲线表明,血清TLR4、NF-κB、IL-17联合检测预测MP患儿发生喘息的敏感度、特异度、曲线下面积明显高于单一指标检测(均P<0.05)。【结论】TLR4、NF-κB和IL-17水平升高与MP患儿发生喘息风险显著相关,三者联合检测具有较高的预测敏感度和特异度。

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	李琳楠
	王永芳
	连会娟

关键词 ：肺炎, 支原体, Toll 样受体4, NF-κB, 白细胞介素-17

Abstract：【Objective】To investigate the relationship of the levels of Toll-like receptor 4 (TLR4), nuclear factor-κB (NF-κB) and interleukin-17 (IL-17) with the occurrence of wheezing in children with mycoplasma pneumonia (MP). 【Methods】 A total of 82 children with MP were enrolled, Based on the presence of clinical symptoms of wheezing and auscultatory findings of wheezing sounds, the children with wheezing were assigned to the observation group, and those without wheezing were assigned to the control group. The serum levels of TLR4, NF-κB, and IL-17 were compared between the two groups. Logistic regression analysis was used to assess the relationship of levels of TLR4, NF-κB and IL-17 with the occurrence of wheezing in the children. The receiver operating characteristic (ROC) curve was employed to evaluate the predictive value of these markers for the occurrence of wheezing in the children with mycoplasma pneumonia. 【Results】 The levels of TLR4, IL-17, and NF-κB in the observation group were significantly higher than those in the control group (all P<0.05). Logistic regression analysis revealed that the levels of TLR4, NF-κB, and IL-17 were positively correlated with the risk of wheezing in the children (all P<0.05). The ROC curve indicated that the combined detection of serum TLR4, NF-κB, and IL-17 had significantly higher sensitivity, specificity, and area under the curve for predicting wheezing in children with MP compared with the detection of a single marker (all P<0.05). 【Conclusion】 Elevated levels of TLR4, NF-κB, and IL-17 are significantly associated with an increased risk of wheezing in children with MP. The combined detection of these three markers exhibits high predictive sensitivity and specificity.

Key words： Pneumonia, Mycoplasma Toll-Like Receptor 4 NF-kappa B Interleukin-17

收稿日期: 2025-04-21

中图分类号:

R725.631

基金资助:^*2024年度郑州市医疗卫生领域科技创新指导计划项目(编号2024YL2DJH130)

引用本文:

李琳楠, 王永芳, 连会娟. Toll样受体4、核因子-κB、白介素-17与支原体肺炎患儿发生喘息的相关性^*[J]. 医学临床研究, 2025, 42(7): 1109-1111.
LI Linnan, WANG Yongfang, LIAN Huijuan. Correlation of Toll-Like Receptor 4, Nuclear Factor-κB and Interleukin-17 Levels with Wheezing in Children with Mycoplasma Pneumonia. JOURNAL OF CLINICAL RESEARCH, 2025, 42(7): 1109-1111.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2025.07.002 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2025/V42/I7/1109

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