Serum HMGB1 and PTX3 Levels and their Correlation with Disease Severity and Prognosis in Children with Mycoplasma Pneumoniae Pneumonia Complicated with Pleural Effusion
TANG Meiling, ZHANG Haili, WANG Jian
Nantong Ruici Hospital Affiliated to Yangzhou University, Nantong Jiangsu 226010
Abstract：【Objective】To investigate the serum levels of high mobility group protein B1 (HMGB1) and pentaprotein 3 (PTX3) and their correlation with disease severity and prognosis in children with mycoplasma pneumoniae pneumonia (MPP) complicated with pleural effusion. 【Methods】A total of 88 children with MPP admitted to our hospital from January 2020 to December 2023 were selected and divided into MPP children with pleural effusion group (combined group, n=58) and MPP children without pleural effusion group (uncombined group, n=30) according to whether the children had pleural effusion. Healthy children who came to our hospital for physical examination at the same period were selected as the control group (n=30). According to the severity of MPP, the combined group was further divided into mild group (n=23), moderate group (n=18) and severe group (n=17), and the combined group was divided into good group (n=27) and adverse group (n=31) according to the prognosis of the children. Serum HMGB1 and PTX3 levels in children with different disease severity were compared, and serum HMGB1 and PTX3 levels in children with different prognosis were compared. Spearman correlation coefficient was used to analyze the correlation between serum HMGB1 and PTX3 and symptoms, disease severity and prognosis of children. 【Results】The levels of serum HMGB1 and PTX3 in the non-combined group and the combined group were significantly higher than those in the control group, and the levels in the combined group were significantly higher than those in the non-combined group, with statistical significance (P<0.05). Serum HMGB1 and PTX3 levels in the moderate group and the severe group were significantly higher than those in the mild group, and the severe group was significantly higher than the moderate group, with statistical significance (P<0.05). The levels of serum HMGB1 and PTX3 in the good group were lower than those in the bad group, and the difference was statistically significant (P<0.05). Spearman correlation analysis showed that serum HMGB1 and PTX3 levels were positively correlated with pleural effusion, disease severity and prognosis (P<0.05). 【Conclusion】 The serum levels of HMGB1 and PTX3 in children with MPP complicated with pleural effusion are significantly correlated with disease severity and prognosis.
唐美玲, 张海丽, 王剑. 肺炎支原体肺炎合并胸腔积液患儿血清HMGB1、PTX3水平及其与疾病严重程度和预后的相关性[J]. 医学临床研究, 2025, 42(3): 467-469.
TANG Meiling, ZHANG Haili, WANG Jian. Serum HMGB1 and PTX3 Levels and their Correlation with Disease Severity and Prognosis in Children with Mycoplasma Pneumoniae Pneumonia Complicated with Pleural Effusion. JOURNAL OF CLINICAL RESEARCH, 2025, 42(3): 467-469.
2025, Vol. 42 
