Predictive Value of Intestinal Flora Combined with Neonatal Immune Function Indexes in Neonatal Infectious Pneumonia in Patients with Gestational Diabetes Mellitus
REN Jianglong, LYU Pengju, HUANG Yongjie, et al
Department of Laboratory Medicine, Zhengzhou University Affiliated Zhengzhou Central Hospital, Zhengzhou Henan 450000
Abstract：【Objective】To investigate the value of intestinal flora combined with neonatal immune function index in predicting neonatal infectious pneumonia in patients with gestational diabetes mellitus (GDM). 【Methods】A total of 82 patients with GDM in late pregnancy admitted to our hospital from August 2023 to October 2024 were divided into infected group (n=10) and uninfected group (n=72) according to whether their newborns developed infectious pneumonia. General data of the two groups were collected, and maternal intestinal flora and neonatal immune indexes were detected. Multivariate logistic regression was used to analyze the risk factors of neonatal infectious pneumonia, and receiver operating characteristic (ROC) curve was used to evaluate the predictive value of maternal intestinal flora combined with neonatal immune indexes for neonatal pneumonia. 【Results】The Chaol index, Shannon index, CD3+, CD4+, CD8+ and IgG in the infected group were lower than those in the uninfected group. The results of multi-factor analysis showed that low Chaol index, Shannon index and IgG were risk factors for neonatal infectious pneumonia (P<0.05). ROC curve analysis results showed that the sensitivity and specificity of maternal intestinal flora combined with neonatal immune indexes in predicting neonatal infectious pneumonia were 97.5% and 95.5%, respectively, and the area under ROC curve was 0.987, both of which were better than single detection. 【Conclusion】The imbalance of maternal intestinal flora and abnormal neonatal immune function indexes are the risk factors for neonatal infectious pneumonia, and the combination of maternal intestinal flora and neonatal immune indexes has high predictive value for neonatal infectious pneumonia.
任江龙, 吕朋举, 黄永杰, 胡守奎. 妊娠期糖尿病患者肠道菌群联合新生儿免疫功能指标对新生儿发生感染性肺炎的预测价值[J]. 医学临床研究, 2025, 42(3): 444-446.
REN Jianglong, LYU Pengju, HUANG Yongjie, et al. Predictive Value of Intestinal Flora Combined with Neonatal Immune Function Indexes in Neonatal Infectious Pneumonia in Patients with Gestational Diabetes Mellitus. JOURNAL OF CLINICAL RESEARCH, 2025, 42(3): 444-446.
2025, Vol. 42 
