Abstract:【Objective】To explore the risk factors related to medication compliance in patients with pulmonary tuberculosis. 【Methods】A retrospective analysis was conducted on the clinical data of 95 patients with pulmonary tuberculosis admitted to our hospital from January 2021 to December 2022. The medication compliance of patients with pulmonary tuberculosis was evaluated using the 8-item Morisky Medication Compliance Scale (MMAS-8). The patients were divided into the good compliance group (MMAS-8 score ≥6 points) and the poor compliance group (MMAS-8 score < 6 points) according to the MMAS-8 score. Univariate analysis was conducted on the clinical data of the two groups of patients, and multivariate Logistic regression analysis was used to analyze the related factors affecting the medication compliance of patients with pulmonary tuberculosis. 【Results】Among the 95 pulmonary tuberculosis patients, a total of 58 patients had a MMAS-8 score of ≥6 points, and the good rate of medication compliance was 61.05%. A total of 37 patients had a MMAS-8 score of <6 points, and the proportion of those with poor medication compliance was 38.95%. There were statistically significant differences between the good compliance group and the poor compliance group in terms of age, living status, per capita family income, cognitive level of tuberculosis knowledge, and psychological distress (P<0.05). Multivariate Logistic regression analysis showed that age ≥60 years old, living alone, low per capita family income, low cognitive level of tuberculosis knowledge, and psychological distress were all independent risk factors affecting the medication compliance of tuberculosis patients (P<0.05).【Conclusion】Age ≥60 years old, living alone, low per capita family income, low cognitive level of tuberculosis knowledge, and psychological distress are all independent risk factors affecting the medication compliance of tuberculosis patients. Clinicians need to pay close attention to the above-mentioned tuberculosis patients, strengthen health education for tuberculosis patients, and improve patients' cognitive level of tuberculosis knowledge, which is helpful to improve the medication compliance of tuberculosis patients.