Abstract：【Objective】 To investigate the risk factors of early left ventricular thrombosis (LVT) in ST segment elevation myocardial infarction (STEMI). 【Method】 A retrospective analysis was conducted on the clinical data of 121 STEMI patients admitted to two hospitals. According to whether the patients had early LVT,they were divided into LVT group (16 cases) and no LVT group (105 cases).The general information of all patients,including total ischemic time (TIT) and Killip grading,was collected; Coronary angiography,echocardiography,blood routine examination,etc. were performed,and isoserological indicators of N-terminal pro-brain natriuretic peptide (NT-proBNP),creatine kinase isoenzyme (CK-MB) peak,cardiac troponin (cTnl) peak,and lipoprotein (α)[Lp(α)] were detected. The value of predicting STEMI combined with early LVT using relevant indicators was analyzed using the receiver operating characteristic (ROC) curve,and the risk factors of STEMI combined with early LVT were analyzed using unconditional logistic stepwise regression. 【Result】 Compared with the non LVT group,the LVT group had a higher proportion of patients with Killip grades Ⅲ-Ⅳ,myocardial infarction thrombolysis (TIMI) blood flow grades<3,no collateral circulation,and left ventricular ejection fraction (LVEF)<40%. Additionally,the LVT group had longer TIMs. The levels of serum CK-MB peak,Lp(α)were relatively high (all P<0.05). According to the ROC analysis,TIT ≥ 10.265 hours,CK-MB peak ≥ 224.128 ng/mL,Lp(α)≥ 308.595 mg/L was the optimal cutoff value for STEMI combined with early LVT (all P<0.05); Logistic regression analysis showed that Killip grade Ⅲ-Ⅳ,TIMI blood flow grade<3,no collateral circulation,LVEF<40%,TIT ≥ 10.265 hours,CK-MB peak ≥224.128 ng/mL,Lp(α)≥ 308.595 mg/L were risk factors for STEMI combined with early LVT (P<0.05).【Conclusion】 The excessive levels of Killip grade Ⅲ-Ⅳ,TIMI blood flow grade<3,no collateral circulation,decreased LVEF,peak serum CK-MB,and Lp(α) may be risk factors for STEMI patients with early LVT.
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2023, Vol. 40 
