Abstract：【Objective】To investigate the clinical effect of liver-spleen-kidney coordinated treatment in patients with spleen deficiency and dampness-toxicity syndrome infected with high-risk cervical human papillomavirus (HR-HPV). 【Methods】A total of 60 patients with spleen deficiency and dampness-toxicity syndrome of cervical HR-HPV infection treated in our hospital from March 2023 to September 2024 were selected and divided into the observation group and the control group according to random number table method, with 30 cases in each group. The observation group was treated with the liver-spleen-kidney-coordinated Wuwei Xiaoduyin decoction, while the control group was treated with Baofukang Suppository vaginal medicine. Both groups were treated for 3 courses of treatment. TCM syndrome score and efficacy, total effective rate of HR-HPV negative conversion, vaginal microecological functional index and occurrence of adverse reactions were compared between the two groups. 【Results】After treatment, the TCM syndrome score of the observation group was (1.86±2.01) points, which was significantly lower than that of control group (5.70±3.10) points, and the difference was statistically significant (P<0.05). The total effective rate of the observation group was 92.86% (26/28), which was significantly higher than that of the control group (66.67%,18/27), and the difference was statistically significant (P<0.05). The total effective rate of HR-HPV negative conversion in the observation group was 32.14% (9/28), compared to 33.33% (9/27) in the control group, there was no significant difference (P>0.05). There were no significant differences in pH abnormality rate, H2O2 positive rate and SNA positive rate between the two groups before and after treatment (P>0.05). The positive rate of LE in the observation group after treatment was significantly lower than before treatment, and the difference was statistically significant (P<0.05). There was no significant difference between the positive rate of LE after treatment and before treatment in control group (P>0.05). There were no obvious adverse reactions after treatment in both groups. 【Conclusion】The total effective rate of negative conversion of HR-HPV in two groups is comparable, and the safety is good. However, the improvement of TCM symptom scores and clinical efficacy in the observation group are better than those in the control group, and the positive rate of LE decreases. The observation group is administered orally, which can be extended to male HR-HPV infection.
2025, Vol. 42 
