艾司西酞普兰联合丙戊酸镁治疗抑郁症患者的疗效

doi:10.3969/j.issn.1671-7171.2024.01.025

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摘要【目的】探讨艾司西酞普兰联合丙戊酸镁治疗抑郁症患者的疗效。【方法】将在延安大学咸阳医院就诊的84例抑郁症患者随机分为两组,每组42例。对照组口服艾司西酞普兰治疗,观察组联合艾司西酞普兰及丙戊酸镁治疗。比较两组治疗效果、治疗前后汉密尔顿抑郁量表(HAMD)评分、汉密尔顿焦虑量表(HAMA)评分、威斯康星卡片分类测验(WCST)评分和5-羟色胺(5-HT)、去甲肾上腺素(NE)水平,治疗后不良反应发生情况。【结果】观察组总有效率为76.19%(32/42),显著高于对照组的54.76%(23/42),且差异有统计学意义(P<0.05);两组治疗后HAMD和HAMA评分均低于治疗前(P<0.05),且观察组低于对照组(P<0.05);两组治疗后5-HT、NE水平均高于治疗前(P<0.05),且观察组高于对照组(P<0.05); 两组治疗后WCST各项评分均显著优于治疗前(P<0.05),且观察组优于对照组(P<0.05); 两组不良反应总发生率比较,差异无统计学意义(P>0.05)。【结论】艾司西酞普兰联合丙戊酸镁可有效缓解抑郁症患者的抑郁、焦虑情绪,改善认知功能,且安全性良好。

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	杨健
	刘哲
	冯玉宏

关键词 ：抑郁症/药物疗法, 西酞普兰/治疗应用, 丙戊酸/治疗应用

Abstract：【Objective】 To explore the efficacy of escitalopram combined with magnesium valproate in the treatment of depression. 【Methods】 A total of 84 depression patients who were treated at Xianyang Hospital of Yan'an University were randomly divided into two groups, with 42 patients in each group.The control group was treated with oral escitalopram, while the observation group was treated with a combination of escitalopram and magnesium valproate. We compared the treatment efficacy, hamilton depression scale (HAMD) scores, hamilton anxiety scale (HAMA) scores, wisconsin card sorting test (WCST) scores, and levels of 5-hydroxytryptamine (5-HT) and norepinephrine (NE) between two groups before and after treatment, as well as the occurrence of adverse reactions after treatment. 【Results】 The total effective rate of the observation group was 76.19%(32/42), significantly higher than the control group's 54.76%(23/42), and the difference was statistically significant (P<0.05); After treatment, the HAMD and HAMA scores of both groups were lower than before treatment (P<0.05), and the observation group was lower than the control group (P<0.05); After treatment, the levels of 5-HT and NE in both groups were higher than before treatment (P<0.05), and the observation group was higher than the control group (P<0.05); After treatment, the WCST scores in both groups were significantly better than before treatment (P<0.05), and the observation group was better than the control group (P<0.05); There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P>0.05).【Conclusion】 Escitalopram combined with magnesium valproate can effectively alleviate depression and anxiety in patients with depression, improve cognitive function, and have good safety.

Key words： Depressive Disorder/DT Citalopram/TU Valproic Acid/TU

收稿日期: 2022-12-30

中图分类号:

R749.42

通讯作者: *Email:328613965@qq.com

引用本文:

杨健, 刘哲, 冯玉宏. 艾司西酞普兰联合丙戊酸镁治疗抑郁症患者的疗效[J]. 医学临床研究, 2024, 41(1): 92-94.
YANG Jian, LIU Zhe, FENG Yuhong. The Value of Escitalopram Combined with Magnesium Valproate in the Treatment of Depression Patients. JOURNAL OF CLINICAL RESEARCH, 2024, 41(1): 92-94.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2024.01.025 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2024/V41/I1/92

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