Abstract：【Objective】 To explore the changes of adhesion factor (sVCAM1), macrophage migration inhibitory factor (MIF) and immunoglobulin E (IgE) expressed by serum soluble vascular endothelial cells during the acute attack of bronchial asthma and their prognostic value. 【Methods】 A total of 126 patients with acute attack of bronchial asthma and 110 patients with non-acute attack of bronchial asthma admitted to our hospital from October 2018 to March 2021 were recorded as acute attack group and non-acute attack group, respectively, and 100 healthy volunteers were recorded as the control group. The serum sVCAM1, MIF and IgE levels of the three groups of subjects were compared. The prognosis of patients with acute attack of bronchial asthma was analyzed and divided into the poor prognosis group and the good prognosis group according to treatment progress and recovery degree. The clinical data of the poor prognosis group and the good prognosis group were compared. Logistic multivariate regression analysis of factors affecting the prognosis of patients with acute bronchial asthma attacks. A receiver operating characteristic curve (ROC) was made to analyze the predictive value of serum sVCAM1, MIF and IgE on the prognosis of patients with acute bronchial asthma attacks. 【Results】 The serum sVCAM1, MIF and IgE levels of the three groups were compared, and the differences were statistically significant (P<0.05). The levels of serum sVCAM1, MIF and IgE in the acute attack group were higher than those in the non-acute attack group and the control group (P<0.05). The serum sVCAM1, MIF and IgE levels of patients in the acute attack group were higher than those in the non-acute attack group (P<0.05). In this study, the incidence of adverse prognosis in patients with acute attack of bronchial asthma during hospitalization was 16.67%. The hospital stay, severity ratio, sVCAM1, MIF and IgE in the poor prognosis group were higher than those in the good prognosis group (P<0.05), and the forced expiratory volume in one second (FEV1)/forced lung capacity (FVC) in the poor prognosis group were lower than those in the good prognosis group (P<0.05).Logistic multivariate analysis showed that severity of the disease, elevated serum sVCAM1, elevated MIF and elevated IgE were all risk factors affecting the prognosis of patients with acute attack of bronchial asthma (OR=2.795, 3.142, 3.022, 3.449, P<0.05). ROC analysis showed that the best cut-off points of serum sVCAM1, MIF, and IgE for predicting the prognosis of patients with acute bronchial asthma attacks were 467.92 ng/L, 51.02 ng/mL, and 285.96 IU/ml, respectively. The area under the curve (AUC) of the triple combination was 0.890, which was higher than the AUC predicted by serum sVCAM1, MIF and IgE alone (P<0.05). 【Conclusion】 The expression of serum sVCAM1, MIF and IgE is higher in patients with acute bronchial asthma, and the combination of the three has a higher prognostic effect on patients with acute bronchial asthma.
梁彩艳, 马敏. sVCAM1、MIF及IgE在支气管哮喘急性发作患者血清中的表达水平及其意义[J]. 医学临床研究, 2024, 41(1): 62-65.
LIANG Caiyan, MA Min. Clinical Significance of Serum sVCAM1, MIF and IgE in Patients with Acute Asthma. JOURNAL OF CLINICAL RESEARCH, 2024, 41(1): 62-65.
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2024, Vol. 41 
