Abstract：【Objective】To explore the effects of different combined general anesthesia methods on serum pain and inflammatory factors in laparoscopic vaginal surgery. 【Methods】A study was conducted on 74 patients with benign uterine diseases who underwent laparoscopic vaginal surgery in two hospitals were randomly divided into the observation group and the control group,with 37 patients in each group. The control group received combined spinal-epidural anesthesia,while the observation group received improved sacral canal block combined with intravenous general anesthesia. Anesthesia related indicators,levels of serum pain factor indicators [dopamine (DA),norepinephrine (NE),and 5-hydroxytryptamine (5-HT)] before and 5 days after surgery, the levels of inflammatory factors [interleukin-6 (IL-6),C-reactive protein (CRP),and Calcitonin (PCT)] before and 3 days after operation,and the adverse reaction rates were compared between the two groups. 【Results】The observation group had shorter onset of anesthesia,complete block time,and postoperative recovery time compared to the control group (P<0.05). There was no statistically significant difference in the duration of surgery between the two groups of patients (P>0.05).The postoperative serum levels of DA,NE,and 5-HT on 5 days after operation in the two groups of patients were significantly higher than those in the same group before surgery (P<0.05). The postoperative serum levels of DA,NE,and 5-HT in the observation group were significantly lower than those in the control group (P<0.05).The levels of serum inflammatory factors IL-6,CRP,and PCT in the two groups of patients on 3 days after surgery were significantly higher than those in the same group before surgery (P<0.05),while the levels of serum inflammatory factors in the observation group were significantly lower than those in the control group (P<0.05). There was no statistically significant difference in the incidence of intraoperative adverse reactions between the two groups of patients (P>0.05). 【Conclusion】In laparoscopic vaginal surgery for the treatment of benign uterine diseases in women,the use of modified sacral canal block combined with intravenous general anesthesia causes less inflammation,faster onset time,and higher safety in patients.
魏锦莉, 李兵. 不同复合全麻方法用于腹腔镜阴式手术中对患者血清疼痛及炎症因子的影响[J]. 医学临床研究, 2023, 40(5): 758-760.
WEI Jin-li, LI Bing. Observation on the Effects of Different Combined General Anesthesia Methods on Serum Pain and Inflammatory Factors in Laparoscopic Vaginal Surgery. JOURNAL OF CLINICAL RESEARCH, 2023, 40(5): 758-760.
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2023, Vol. 40 
