TIMD4 对CNSCLC患者预后的诊断价值分析

doi:10.3969/j.issn.1671-7171.2023.02.011

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摘要【目的】探讨T细胞免疫球蛋白和黏蛋白结构域4(TIMD4) 对中央型非小细胞肺癌(CNSCLC)患者预后的诊断价值。【方法】选择2015年4月至2017年6月在榆林市横山区人民医院接受治疗的139例CNSCLC患者,所有患者均采用经导管动脉化疗栓塞(TACE)联合经皮射频消融(RFA)治疗,根据3年预后情况分为生存组和死亡组。采用蛋白质免疫印迹法检测单个核细胞中TIMD4表达水平,分析TIMD4 对CNSCLC患者预后的诊断价值。【结果】生存组和死亡组TIMD4水平均随时间进展呈降低趋势(P<0.05)。生存组T₁、T₂时TIMD4水平低于死亡组,差异均有统计学意义(P<0.05)。高TIMD4组中位生存时间低于低TIMD4组,差异有统计学意义(P<0.05)。COX回归分析结果显示:TNM分期和T₂时TIMD4是CNSCLC患者预后的独立危险因素(P<0.05);分化程度高和服用靶向药是CNSCLC患者预后的独立保护因素(P<0.05)。由TNM分期、分化程度、服用靶向药和T₂时TIMD4构建的列线图回归模型的拟合曲线与理想曲线重合度较高,且一致性指数C-index为0.803。【结论】CNSCLC患者TIMD4水平高提示预后不良风险高,基于TIMD4构建的列线图回归模型有较高的精准度和区分度,可评估CNSCLC患者预后。

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	王茹
	张敏
	李军社

关键词 ：癌, 非小细胞肺/病理学, 蛋白质类/分析, 预后

Abstract：【Objective】To investigate the diagnostic value of T cell immunoglobulin and mucin domain 4 (TIMD4) in the prognosis of patients with central non-small cell lung cancer (CNSCLC).【Methods】A total of 139 patients with CNSCLC who received treatment in our hospital from April 2015 to June 2017 were selected as the research subjects. All patients were treated with transcatheter arterial chemoembolization (TACE) combined with percutaneous radiofrequency ablation (RFA). According to the 3-year prognosis,patients were divided into the survival group and the death group. Mononuclear cells were isolated by Ficoll density gradient centrifugation method. Western blotting was used to detect the expression level of TIMD4 in mononuclear cells,and the diagnostic value of TIMD4 in the prognosis of CNSCLC patients was analyzed. 【Results】The expression level of TIMD4 in the survival group and the death group showed a decreasing trend over time (P<0.05). The expression levels of TIMD4 at T₁ and T₂ in the survival group were lower than those in the death group,and the differences were statistically significant (P<0.05). The median survival time of the high TIMD4 group was lower than that of the low TIMD4 group; And the difference was statistically significant (P<0.05). COX regression analysis showed that TNM staging and T₂-TIMD4 were independent risk factors for the prognosis of CNSCLC patients (P<0.05),while the differentiation degree and taking targeted drugs were independent protective factors for the prognosis of CNSCLC patients (P<0.05). The fitting curve of the nomogram regression model constructed by TNM staging,degree of differentiation,taking targeted drugs and T₂-TIMD4 had a higher degree of coincidence with the ideal curve,whose consistency index C-index was 0.803. 【Conclusion】High TIMD4 expression in CNSCLC patients indicates a high risk of poor prognosis. The nomogram regression model based on TIMD4 has high accuracy and discrimination,which can evaluate the prognosis of CNSCLC patients.

Key words： Carcinoma, Non-Small-Cell Lung/PA Proteins/AN Prognosis

收稿日期: 2022-03-08

中图分类号:

R734.2

通讯作者: *E-mail:1114835819@qq.com

引用本文:

王茹, 张敏, 李军社. TIMD4 对CNSCLC患者预后的诊断价值分析[J]. 医学临床研究, 2023, 40(2): 198-201.
WANG Ru, ZHANG Min, LI Jun-she. Diagnostic Value of TIMD4 in the Prognosis of Patients with CNSCLC. JOURNAL OF CLINICAL RESEARCH, 2023, 40(2): 198-201.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2023.02.011 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2023/V40/I2/198

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