Meta Analysis to Valuate the Efficacy and Safety of Reduning Injection Combined with Antibiotics in the Treatment of Community Acquired Pneumonia in Children
LI Guo-ying, CHEN Liang, LIU Jun
The Seventh Affiliated Hospital of Xinjiang Medical University, Urumqi 830028,China
Abstract：【Objective】 To evaluate the clinical efficacy and safety of Reduning injection combined with antibiotics in the treatment of children community acquired pneumonia by Meta-analysis. 【Methods】Randomized controlled trials were retrieved in Pubmed,Embase,CBM,CNKI,VIP and Wanfang database.Quality of the RCTs was evaluated strictly by using the Jadad quality evaluation method,statistical analysis was performed using Meta-analysis.【Results】 Finally, 8 articles were included in the study, the total number of cases was 2451. The results of meta analysis showed that: compared with the single antibiotic group, the combined drug group had more advantages in the total effective rate[WMD=-2.64,95%CI (-2.75,-2.54),P<0.0001], the disappearance time of cough [WMD=-0.96,95%CI (-1.18,-0.74),P<0.00001], asthma and sputum, the disappearance time of lung rale[WMD=-0.96,95%CI(-1.18,-0.74),P<0.05], the shadow absorption time of X-ray focus[WMD=-2.88,95%CI(-3.05,-2.71),P<0.00001], the disappearance time of respiratory shortness of breath[WMD=-1.26,95%CI(-1.32,-1.20),P<0.05] and the difference was statistically significant (P<0.05).【Conclusion】Reduning combined with antibiotics is safe and effective in the treatment of children's community-acquired pneumonia, but more high-quality large sample, multicenter, randomized, double-blind, controlled clinical trials are needed to further confirm.
李国英, 陈良, 刘军. Meta分析评价热毒宁注射液联合抗生素治疗儿童社区获得性肺炎的疗效及安全性[J]. 医学临床研究, 2020, 37(3): 385-389.
LI Guo-ying, CHEN Liang, LIU Jun. Meta Analysis to Valuate the Efficacy and Safety of Reduning Injection Combined with Antibiotics in the Treatment of Community Acquired Pneumonia in Children. JOURNAL OF CLINICAL RESEARCH, 2020, 37(3): 385-389.
2020, Vol. 37 
