Abstract：【Objective】To summarize the clinical and histopathological features of granuloma annularis in children. 【Methods】The clinical data and histopathological findings of 18 children with granuloma annulare diagnosed and treated in children's Hospital of Soochow University from January 2013 to December 2018 were analyzed retrospectively. 【Results】The skin lesions were mostly characterized by single circular erythema or plaques fused by red papules with clear boundary. Histopathological examination showed palisade granulomatous changes in the dermis with degenerated collagen fibers in the center and palisade arrangement of lymphocytes, histiocytes and a small number of epithelioid cells around the dermis. 【Conclusion】According to the typical skin lesion characteristics and pathological manifestations, the diagnosis of granuloma annular can be confirmed.
鲁慧, 钱华, 李巍, 胡翠. 18例儿童环状肉芽肿临床及组织病理分析[J]. 医学临床研究, 2019, 36(12): 2305-2306.
LU Hui, QIAN Hua, LI Wei, et al. Clinical and Pathological Analysis of 18 Cases of Children with Granuloma Annulare. JOURNAL OF CLINICAL RESEARCH, 2019, 36(12): 2305-2306.
[1] 吕永梅,杨春俊,张学军.环状肉芽肿的病因及相关发病机制的研究进展[J].中国皮肤性病学杂志, 2017, 31(12):1371-1373. [2] Bolognia JL, Jorizzo JL, Schaffer JV. Dermatology[M]. 北京:北京大学医学出版社,2012:1753-1756. [3] Friedman SJ, Fox BJ, Albert HL. Granuloma annulare arising in herpes zoster scars report of two cases and review of the literature [J].J Am Acad Dermatol,1986,14(1):764-770. [4] Hu SW, Kaplan J, Patel RR,et al. Trauma-related popular granuloma annular[J].Dermatol Online J,2013,19(12):207-219. [5] Piette EW, Rosenbach M. Granuloma annular: pathogenesis, disease associations and triggers, and therapeutic options [J].J Am Acad Dermatol,2016,75(3):467-479. [6] 王逸飞,繆秋菊,徐秀莲.环状肉芽肿发病机制与治疗研究进展[J].中国麻风皮肤病杂志,2019,35(1):57-60. [7] Krasovec M, Frenk E. Generalized granuloma annulare [J].Ann Dermatol Venereol,1994,121(2):170-174. [8] 黄萌,陈柳青,覃莉,等. 环状肉芽肿142例临床和组织病理分析[J].临床皮肤科杂志,2011,40(3):142-144. [9] 赵林胜,蔡春泉,赵丽,等. 儿童结节型环状肉芽肿9例临床病理分析[J].临床与实验病理学杂志,2015,31(10):1159-1161. [10] Felner EI, Steinberg JB, Weinerg AG. Subcutaneous granuloma annlare :a review of 47 cases [J].Pediatrics,1997,100(6):965-967. [11] Friedman BR, haim S, Gideoe O, et al. Histocompatibility antigens in granuloma annulare comparative study of the generalized and locatized [J].Br J Dermatol,1978,98(4):425-428. [12] Patrizi A, Gurioli C. Childhood granuloma annulare: a review [J].Gital Dermatol Venereol,2014,149(6):663-674. [13] Rallis E, Stavpoulou E, Korfitis C. Granuloma annulare of childhood successfully treated with potent topical corticosteroids previously unrespones cortices corticosteroids previous unresponsive to tacrolimus ointment 0.1%: report of three cases [J].Clin Exp, Dermatol,2009,34(7):475-476.
2019, Vol. 36 
