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Quick Search     Adv Search 2026 Vol. 43, No. 2 Published: 2026-02-26 Original Articles          Original Articles 177 The Regulatory Role of LINC00475 in Synovial Fibroblasts and its Correlation with the Progression of Rheumatoid Arthritis HE Liwei, TAN Yuxuan, GUO Yupeng, HUANG Shu, ZHOU Yizhao DOI: 10.3969/j.issn.1671-7171.2026.02.001 【Objective】 To explore the regulatory role of LINC00475 in synovial fibroblasts (SFs) and its correlation with the progression of rheumatoid arthritis (RA). 【Methods】 A total of 60 patients who underwent knee joint surgery in Hunan Provincial People's Hospital from February 2019 to February 2020 were selected. According to different disease types, the patients were divided into the RA group (RA patients, n=30) and the control group (patients with meniscus injury without joint disease, n=30). SFs were isolated, cultured, proliferated and transfected, and the relationship between SFs apoptosis and target regulatory factors was analyzed by dual-luciferase reporter gene assay, immunofluorescence staining, Western blot analysis and other methods. 【Results】 The expression level of LINC00475 in synovial tissue of the RA group was significantly higher than that of the control group, and the difference was statistically significant (P<0.05). The expression level of miR-27b-3p in synovial tissue of the RA group was lower than that of the control group, and the difference was statistically significant (P<0.05). Correlation analysis showed that the increased expression level of LINC00475 was positively correlated with the progression of RA (P<0.05). Western blot results showed that the expression of RC3H1 in synovial tissue of RA patients was significantly higher than that in the normal group (P<0.05). Dual-luciferase reporter gene assay showed that there was a direct interaction between LINC00475 and miR-27b-3p, as well as between miR-27b-3p and RC3H1. The results of immunofluorescence staining, Western blot and qRT-PCR all showed that the expression level of RC3H1 in SFs of the LINC00475-WT group was significantly higher than that of the LINC00475 mutant group and the control group (P<0.05). Western blot and qRT-PCR results showed that compared with the normal group and the transfection control group, the expression level of RC3H1 in the LINC00475 overexpression group and the miR-27b-3p low expression group was significantly decreased (P<0.05); the expression level of RC3H1 in the LINC00475 low expression group and the miR-27b-3p high expression group was increased (P<0.05). Immunofluorescence results showed that both LINC00475 overexpression and miR-27b-3p knockdown upregulated the expression intensity of RC3H1, and the LINC00475 overexpression group showed a more significant upregulation effect. Cell proliferation assay showed that compared with the control group, overexpression of LINC00475 or RC3H1 could promote the proliferation of SFs; knockdown of LINC00475 or RC3H1 significantly inhibited the proliferation of SFs. 【Conclusion】 As a competing endogenous RNA, LINC00475 promotes the high expression of RC3H1 gene by adsorbing miR-27b-3p, induces SFs autophagy, inhibits SFs apoptosis, and ultimately leads to abnormal proliferation of SFs, thereby accelerating the progression of RA. 2026 Vol. 43 (2): 177-181 [Abstract] ( 14 ) HTML (1 KB)  PDF (2130 KB)  ( 1 ) 182 Effects of Repetitive Transcranial Magnetic Stimulation Combined with a Rehabilitation Herbal Formula on Related Functions in Patients with Stroke GUAN Rui, LI Qiaoli, ZHAO Yasha, GUI Feifei, LI Yong DOI: 10.3969/j.issn.1671-7171.2026.02.002 【Objective】 To investigate the effects of repetitive transcranial magnetic stimulation (rTMS) combined with a rehabilitation herbal decoction on functional recovery in patients with stroke.【Methods】 A total of 84 stroke patients were randomly divided into a control group and an observation group, with 42 patients in each group. Based on conventional rehabilitation therapy, the control group received rTMS, while the observation group received rTMS combined with a traditional Chinese medicine rehabilitation decoction. Motor function [Fugl-Meyer Assessment (FMA), Wolf Motor Function Test (WMFT), and Brunel Balance Scale (BBS) score], neurological function [National Institutes of Health Stroke Scale (NIHSS) score], cognitive function [Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE) score], serum brain-derived neurotrophic factor (BDNF) level, and adverse reactions were compared between the two groups before and after treatment.【Results】 After treatment, FMA, WMFT, BBS, MoCA, MMSE score, and BDNF level in the observation group were significantly higher than those in the control group (P<0.05), while NIHSS score was significantly lower (P<0.05). There was no statistically significant difference in the overall incidence of adverse reactions between the two groups (P>0.05).【Conclusion】 rTMS combined with a rehabilitation herbal formula can effectively improve motor function, neurological function, and cognitive function in stroke patients, with good safety. 2026 Vol. 43 (2): 182-185 [Abstract] ( 11 ) HTML (1 KB)  PDF (1172 KB)  ( 1 ) 186 The Application Effect of Palliative Care Centered on Dignity Therapy in Elderly Terminally Ill Patients FAN Weixia, ZHANG Huicong, YANG Liu, JIA Meiyun DOI: 10.3969/j.issn.1671-7171.2026.02.003 【Objective】 To explore the application effect of palliative care centered on dignity therapy in elderly terminally ill patients. 【Methods】 A total of 88 elderly terminally ill patients who received palliative care in our hospital from January 2020 to February 2025 were selected and divided into a control group (receiving routine palliative care intervention) and an observation group (receiving palliative care intervention based on dignity therapy) with 44 cases in each group using the random number table method. The psychological distress level [Distress Management Screening Measure (DMSM) score], sense of dignity [Patient Dignity Inventory (PDI) score], self-esteem level [State Self-Esteem Scale (SSES) score], fear status [Fear of Progression Questionnaire (FoP-Q) score] and quality of end-of-life care [Palliative Outcome Scale (POS) score] were compared between the two groups. 【Results】 After intervention, the DMSM scores and PDI scores of both groups were lower than those before intervention, and the observation group was lower than the control group, with statistically significant differences (P<0.05). The scores of behavioral self-esteem, social self-esteem and total score of both groups were higher than those before intervention, and the observation group was higher than the control group, with statistically significant differences (P<0.05). The scores of emotional response, occupational impact, limited autonomy, intimate relationship/family support, anxiety coping and total score of both groups were lower than those before intervention, and the observation group was lower than the control group, with statistically significant differences (P<0.05). The scores of pain management, symptom relief, emotional anxiety, family emotional burden, information acquisition and communication, support level, self-cognition, sense of life meaning, time consumption and affair handling in the observation group were lower than those in the control group, with statistically significant differences (P<0.05). 【Conclusion】 Palliative care based on dignity therapy can effectively alleviate the psychological distress and fear of elderly terminally ill patients, and improve their sense of dignity, self-esteem level and quality of end-of-life care. 2026 Vol. 43 (2): 186-189 [Abstract] ( 11 ) HTML (1 KB)  PDF (1169 KB)  ( 0 ) 190 Application of Controlled Circulation-Based Low Central Venous Pressure Technique in Hepatectomy XU Bing, WANG Jin, ZHANG Shuai DOI: 10.3969/j.issn.1671-7171.2026.02.004 【Objective】 To investigate the clinical efficacy and safety of a controlled circulation-based low central venous pressure (LCVP) technique in hepatectomy.【Methods】 A total of 86 patients undergoing hepatectomy were randomly divided into an observation group and a control group, with 43 patients in each group. The control group received conventional anesthesia management, while the observation group was managed with the controlled circulation-based LCVP technique. Surgical variables were compared between the two groups. Hemodynamic parameters-mean arterial pressure (MAP) and heart rate (HR) were recorded before anesthesia induction (T0), 1 min after tracheal intubation (T1), 1 min after the start of hepatic parenchymal transection (T2), and at the end of surgery. Liver function indices-alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total bilirubin (TBil) were measured preoperatively and 7 days postoperatively. Safety outcomes were also assessed. 【Results】 Intraoperative blood loss, fluid infusion volume, urine output, and blood transfusion rate in the observation group were all lower than those in the control group, and the operative time in the observation group was shorter (P<0.05). At T1, T2, and at the end of surgery, MAP and HR in the observation group were significantly lower than those in the control group (P<0.05). Seven days after surgery, levels of ALT, AST, and TBil were significantly lower in the observation group than in the control group (P<0.05). The overall incidence of adverse reactions was also lower in the observation group than that in the control group (P<0.05).【Conclusion】 The controlled circulation-based LCVP technique can effectively reduce intraoperative blood loss, fluid infusion volume, and urine output, decrease transfusion requirements, lower MAP and HR, shorten operative time, and promote postoperative recovery of liver function in patients undergoing hepatectomy, with good safety. This technique is worthy of clinical application and promotion. 2026 Vol. 43 (2): 190-192 [Abstract] ( 12 ) HTML (1 KB)  PDF (1149 KB)  ( 0 ) 193 Construction and Validation of a Predictive Model for Pelvic Organ Prolapse Combined with Occult Stress Urinary Incontinence Based on Transperineal Pelvic Floor Ultrasound Parameters and Three-Dimensional Vaginal Ultrasound Parameters YANG Jiayi, WANG Jue DOI: 10.3969/j.issn.1671-7171.2026.02.005 【Objective】 To investigate the construction and validation of a predictive model for pelvic organ prolapse (POP) combined with occult stress urinary incontinence (OSUI) based on transperineal pelvic floor ultrasound parameters and three-dimensional vaginal ultrasound parameters. 【Methods】 A total of 136 patients with pelvic organ prolapse diagnosed and treated in our hospital from January 2020 to October 2025 were selected. According to the 80/20 rule, they were randomly divided into a training set (n=106) and a validation set (n=30). The 106 patients in the training set were further divided into a combined group (n=58, with OSUI) and a non-combined group (n=48, without OSUI) based on the presence or absence of occult stress urinary incontinence. Transperineal pelvic floor ultrasound parameters [at rest: urethral inclination angle (R-UI), bladder-urethral posterior angle (R-RVA); under Valsalva maneuver: urethral inclination angle (V-UI), bladder-urethral posterior angle (V-RVA), urethral rotation angle (UR)] and three-dimensional vaginal ultrasound parameters [at rest: levator ani hiatus area (R-ALH); under Valsalva maneuver: levator ani hiatus area (V-ALH), bladder neck descent (BND), and funneling of the internal urethral orifice] were compared between the two groups. Risk factors for the occurrence of POP combined with OSUI were screened. A predictive model for POP combined with OSUI based on transperineal pelvic floor ultrasound parameters and three-dimensional vaginal ultrasound parameters was constructed and validated.【Results】 R-UI, V-RVA, UR, BND, V-ALH, and the incidence of funneling of the internal urethral orifice in the combined group were higher than those in the non-combined group (P<0.05). No statistically significant differences were found in R-RVA and V-UI between the two groups (P>0.05). R-UI, V-RVA, UR, BND, V-ALH, and funneling of the internal urethral orifice were identified as influencing factors for the occurrence of POP combined with OSUI (P<0.05). In the training set, the nomogram model predicted POP combined with OSUI with a sensitivity of 0.781, specificity of 0.799, and area under the curve (AUC) of 0.819. In the validation set, the nomogram model predicted POP combined with OSUI with a sensitivity of 0.776, specificity of 0.791, and AUC of 0.805. 【Conclusion】 The predictive model for POP combined with OSUI constructed based on transperineal pelvic floor ultrasound parameters and three-dimensional vaginal ultrasound parameters demonstrates good performance in assisting the prediction of POP combined with OSUI. 2026 Vol. 43 (2): 193-197 [Abstract] ( 9 ) HTML (1 KB)  PDF (1284 KB)  ( 0 ) 198 Application Effect of Acceptance and Commitment Therapy in Patients with Endometrial Cancer SHANG Jing, WANG Yu, LI Yanyan DOI: 10.3969/j.issn.1671-7171.2026.02.006 【Objective】 To explore the application effect of Acceptance and Commitment Therapy (ACT) in patients with endometrial cancer. 【Methods】 A total of 120 patients with endometrial cancer admitted to our hospital from December 2020 to December 2023 were selected as the research subjects and randomly divided into an observation group and a control group, with 60 cases in each group. The control group received routine nursing care, while the observation group received ACT care in addition to routine nursing care. The negative emotions [Self-Rating Anxiety Scale (SAS) score and Self-Rating Depression Scale (SDS) score], psychological flexibility [Acceptance and Action Questionnaire-Ⅱ (AAQ-Ⅱ) score], Spitzer Quality of Life Index (SQOL), and nursing satisfaction were compared between the two groups. 【Results】 After the intervention, the SAS, SDS, and AAQ-Ⅱ scores of both groups were significantly lower than those before the intervention, and the SQOL score was significantly higher than that before the intervention. Moreover, the SQOL score in the observation group was superior to the control group (P<0.05). The nursing satisfaction of the observation group was significantly higher than that of the control group (P<0.05). 【Conclusion】 The application of ACT in patients with endometrial cancer can significantly improve the psychological state and quality of life of patients and enhance nursing satisfaction. 2026 Vol. 43 (2): 198-200 [Abstract] ( 14 ) HTML (1 KB)  PDF (1142 KB)  ( 0 ) 201 Effect of Ultrasound-Guided Modified Lumbar Plexus Block in Total Hip Arthroplasty LIU Yongbin, MA Peng, WANG Renjun DOI: 10.3969/j.issn.1671-7171.2026.02.007 【Objective】 To investigate the effect of ultrasound-guided modified lumbar plexus block(LPB) in patients undergoing total hip arthroplasty (THA).【Methods】 A total of 120 patients undergoing THA in our hospital were divided into an observation group and a control group according to different preoperative anesthesia methods, with 60 patients in each group. The observation group received ultrasound-guided modified LPB combined with sacral plexus block, while the control group received ultrasound-guided LPB combined with sacral plexus block. Clinical indicators and anesthetic effects were compared between the two groups. Hemodynamic parameters, including mean arterial pressure (MAP) and heart rate (HR), were recorded upon entering the operating room (T0), 5 minutes after anesthesia (T1), and 30 minutes after the start of surgery (T2). Serum pain-related factors-prostaglandin E2 (PGE2), neuropeptide Y (NPY), and nerve growth factor (NGF) were measured before entering the operating room and 12 hours postoperatively, and adverse reactions were recorded.【Results】 There were no significant differences between the two groups in terms of puncture time, block completion time, surgical duration, and femoral nerve recovery time (P>0.05). Intraoperative sufentanil consumption was significantly lower in the observation group than in the control group (P<0.05). No significant differences were observed in MAP and HR between the two groups at each time point (P>0.05); however, MAP and HR at T2 in the observation group were significantly lower than those at T0 and T1 within the same group (P<0.05). The excellent-to-good anesthesia rate was significantly higher in the observation group (98.33%) than in the control group (88.33%) (P<0.05). Serum PGE2, NPY, and NGF levels at 12 hours postoperatively were higher than preoperative levels in both groups (P<0.05), but they were significantly lower in the observation group than in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).【Conclusion】 Ultrasound-guided modified LPB in THA provides effective anesthesia, reduces opioid consumption, and improves postoperative analgesia. 2026 Vol. 43 (2): 201-204 [Abstract] ( 11 ) HTML (1 KB)  PDF (1176 KB)  ( 0 ) 205 Application Value of Low-Frequency Neuromuscular Electrical Stimulation Combined with a Motor Control System in Patients with Post-Stroke Hemiplegia FENG Xiaoyang DOI: 10.3969/j.issn.1671-7171.2026.02.008 【Objective】 To investigate the therapeutic effects of low-frequency neuromuscular electrical stimulation (NMES) combined with a motor control system in the rehabilitation of patients with post-stroke hemiplegia (PSH).【Methods】 A total of 106 patients with PSH were randomly divided into a control group (receiving conventional treatment combined with a motor control system) and an observation group (receiving NMES combined with a motor control system). The inflammatory factors [tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and C-reactive protein (CRP)], coagulation indices [fibrinogen (FIB), activated partial thromboplastin time (APTT), prothrombin time (PT), and D-dimer (D-D)], neurological function [National Institutes of Health Stroke Scale (NIHSS)], muscle strength of the upper and lower limbs (Lovett score), balance function [Berg Balance Scale (BBS)], and activities of daily living [Modified Barthel Index (BI)] were compared between the two groups before and after treatment.【Results】 After 12 weeks of treatment, levels of TNF-α, IL-6, CRP, FIB, and NIHSS scores decreased significantly in both groups compared with baseline before treatment, and they were significantly lower in the observation group than in the control group (P<0.05). APTT, PT, D-D levels, Lovett scores of the upper and lower limbs, BBS scores, and BI scores significantly increased in both groups compared with baseline before treatment (P<0.05); And these indicators in the observation group were higher than those in the control group (P<0.05).【Conclusion】 NMES combined with a motor control system can significantly enhance neurological function recovery and improve activities of daily living in patients with post-stroke hemiplegia. 2026 Vol. 43 (2): 205-207 [Abstract] ( 8 ) HTML (1 KB)  PDF (1147 KB)  ( 0 ) 208 Efficacy of High-Frequency Repetitive Transcranial Magnetic Stimulation Combined with Neural Facilitation Techniques for Treating Cognitive Dysfunction after Stroke ZHANG Linling, ZHU Yaoyao, YAN Wenjuan DOI: 10.3969/j.issn.1671-7171.2026.02.009 【Objective】 To investigate the efficacy of high-frequency repetitive transcranial magnetic stimulation (rTMS) combined with neural facilitation techniques in treating patients with post-stroke cognitive impairment (PSCI). 【Methods】 A total of 82 PSCI patients were randomly divided into two groups with 41 cases each. The control group received basic treatment and neural facilitation techniques. The observation group received rTMS in addition to the same interventions as the control group. Both groups underwent interventions for 8 weeks. The clinical efficacy, cerebral hemodynamics, neurotrophic factor levels, cognitive function, and quality of life before and after treatment were compared between the two groups. 【Results】 The total effective rate in the observation group was higher than that in the control group (P<0.05). After treatment, the levels of various neurotrophic factors, the mean blood flow velocity, and the peak systolic flow velocity in the middle cerebral artery of the observation group were higher than those of the control group, while the pulsatility index was lower (P<0.05). Cognitive function, memory function, and quality of life in the observation group showed significantly greater improvement compared to the control group (P<0.05). 【Conclusion】 The combination of rTMS and neural facilitation techniques can improve the cognitive abilities, cerebral hemodynamics, neurotrophic factor levels, and quality of life in PSCI patients. 2026 Vol. 43 (2): 208-211 [Abstract] ( 7 ) HTML (1 KB)  PDF (1173 KB)  ( 1 ) 212 Effect of Perioperative Comprehensive Nursing Care under the FTS Concept on Hip Joint Function and Quality of Life in Patients with Femoral Neck Fractures GONG Xu DOI: 10.3969/j.issn.1671-7171.2026.02.010 【Objective】 To explore the effect of perioperative full-course nursing guided by the fast track surgery (FTS) concept on hip joint function and quality of life in patients with femoral neck fractures. 【Methods】 A total of 76 patients with femoral neck fractures who were treated in our hospital from June 2021 to May 2023 were selected and randomly divided into a control group and an observation group, with 38 cases in each group. The control group received routine perioperative care, while the observation group received perioperative full-course care based on the FTS concept in addition to the care provided in the control group. Clinical indicators, Harris hip score (HHS), visual analogue scale (VAS) score, self-perceived burden scale (SPBS) score, Barthel index of activities of daily living (ADL), and 36-Item Short Form Health Survey (SF-36) quality of life scale scores were compared between the two groups. 【Results】 The extubation time, first time out of bed, and hospital stay in the observation group were shorter than those in the control group, and the differences were statistically significant (P<0.05). After the intervention, the HHS, Barthel index, and SF-36 scores in the observation group were higher than those in the control group, while the SPBS score in the observation group was lower than that in the control group, with statistically significant differences (P<0.05). On the 1st, 3rd, and 7th days after surgery, the VAS scores of both groups were lower than those before surgery, and the VAS scores of the observation group were lower than those of the control group, with statistically significant differences (P<0.05). 【Conclusion】 Perioperative full-course care based on the FTS concept can significantly improve hip joint function and quality of life in patients with femoral neck fractures, reduce pain, and shorten the recovery time. 2026 Vol. 43 (2): 212-215 [Abstract] ( 7 ) HTML (1 KB)  PDF (1163 KB)  ( 0 ) 216 Efficacy of Anlotinib in the Treatment of EGFR-Positive Non-Small Cell Lung Cancer and its Effects on CA125 and MMP-2 Levels ZHOU Lei, LI Yongwei, JIANG Xiaojie, ZHAO Liang DOI: 10.3969/j.issn.1671-7171.2026.02.011 【Objective】 To investigate the efficacy of anlotinib in patients with epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) and its effects on the tumor markers cancer antigen 125 (CA125) and matrix metalloproteinase-2 (MMP-2).【Methods】 A total of 87 patients with EGFR-positive NSCLC were enrolled. Among them, 41 patients received anlotinib treatment (the observation group), and 46 patients received conventional treatment (the control group). Clinical efficacy, immune function, adhesion molecules [soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1)], levels of CA125 and MMP-2 before and after treatment, incidence of adverse reactions, and survival outcomes were compared between the two groups.【Results】 The objective response rate (ORR) in the observation group was significantly higher than that in the control group (P<0.05). After treatment, the observation group showed higher level of CD3+/CD4+ T cells and a higher CD3+CD4+/CD3+CD8+ ratio, but a lower CD3+/CD8+ ratio compared with the control group (P<0.05). Levels of sICAM-1, sVCAM-1, CA125, and MMP-2 in the observation group were significantly lower than those in the control group (P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05). The 3-month disease-free survival rate in the observation group was significantly higher than that in the control group (P<0.05).【Conclusion】 Anlotinib is safe and effective treatment for patients with EGFR-positive NSCLC. It can improve immune function and reduce tumor marker levels. 2026 Vol. 43 (2): 216-218 [Abstract] ( 8 ) HTML (1 KB)  PDF (1148 KB)  ( 0 ) 219 Influence of Cognitive Level of Clinical Symptoms, Treatment Methods and Other Related Knowledge on Emergency PCI Decision-Making in STEMI Patients PENG Nanying, LIU Qin, JIN Zhao, XU WeiFang, OU YaLi, YU Guolong DOI: 10.3969/j.issn.1671-7171.2026.02.012 【Objective】 To explore the influence of cognitive level of clinical symptoms, treatment methods and other related knowledge on the decision-making of emergency percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction(STEMI). 【Methods】 A total of 195 inpatients with STEMI admitted to our department from July 2021 to July 2022 were selected. According to whether emergency PCI was performed, the patients were divided into the emergency PCI group (n=68) and the non-emergency PCI group (n=127). The awareness of main clinical symptoms of acute myocardial infarction (AMI), first reaction when AMI occurred and treatment methods was compared between the two groups. 【Results】 The proportion of receiving health education in the emergency PCI group was significantly higher than that in the non-emergency PCI group, and the proportion of pre-hospital treatment delay was significantly lower than that in the non-emergency PCI group, with statistically significant differences (P<0.05). The proportion of patients in the emergency PCI group who knew that sudden chest pain or discomfort, sudden shortness of breath or dyspnea were the onset symptoms of AMI was significantly higher than that in the non-emergency PCI group, with a statistically significant difference (P<0.05). The proportions of patients in the emergency PCI group whose first reaction to AMI was to call 120 emergency ambulance and contact the nearest community hospital for advice were significantly higher than those in the non-emergency PCI group, with statistically significant differences (P<0.05). The proportion of patients in the emergency PCI group who knew that PCI was a treatment method for AMI was significantly higher than that in the non-emergency PCI group, and the proportion of those who did not know the treatment method for AMI was significantly lower than that in the non-emergency PCI group, with a statistically significant difference (P<0.05). Multivariate Logistic regression analysis showed that knowing the symptom of sudden shortness of breath or dyspnea when AMI occurs, knowing PCI, as well as the first reaction of calling 120 emergency ambulance and contacting doctors of the nearest hospital for advice when symptoms occur were independent protective factors for AMI patients to make emergency PCI decisions (P<0.05).【Conclusion】 The proportion of STEMI patients receiving emergency PCI is too low. The cognitive level of main clinical symptoms of AMI, first reaction when AMI occurs and treatment methods significantly affects the emergency PCI decision-making of STEMI patients. 2026 Vol. 43 (2): 219-223 [Abstract] ( 8 ) HTML (1 KB)  PDF (1196 KB)  ( 1 ) 224 Clinical Efficacy of Health Belief Model Nursing Combined with Biofeedback Electrical Stimulation in the Treatment of Stress Urinary Incontinence in Elderly Women XIE Qiuxia, LIAO Lei, HU Haiqin DOI: 10.3969/j.issn.1671-7171.2026.02.013 【Objective】 To investigate the clinical efficacy of health belief model nursing combined with biofeedback electrical stimulation in the treatment of stress urinary incontinence (SUI) in elderly women. 【Methods】 A total of 87 elderly female patients with SUI admitted to our hospital from March 2021 to March 2023 were selected and randomly divided into a control group (receiving biofeedback electrical stimulation treatment, n=43) and an observation group (receiving health belief model nursing combined with biofeedback electrical stimulation treatment). Urine leakage conditions (1-hour urine leakage volume, frequency of urine leakage at 24 h and 72 h) at 1 month after intervention, urodynamic indices [Valsalva leak point pressure (VLPP), maximum urethral closure pressure (MUCP), maximum urethral pressure (MUP), bladder compliance (BC), functional urethral length (FUL), maximum cystometric capacity at strong desire to void (MCC), and detrusor pressure at maximum flow rate (PQmax)] before and at 1 month after intervention, pelvic floor function [pelvic floor muscle strength, electromyography value, and Pelvic Floor Distress Inventory-20 (PFDI-20) score] before and at 1 month after intervention, and quality of life [Incontinence Quality of Life (I-QOL) score] before intervention, at 1 month and 3 months after intervention were compared between the two groups. 【Results】 At 1 month after intervention, the 1-hour urine leakage volume and the frequency of urine leakage at 24 h and 72 h in the observation group were significantly lower than those in the control group (P<0.05). The VLPP, MUCP, MUP, BC, FUL, MCC, and PQmax in the observation group were significantly higher than those in the control group (P<0.05). The pelvic floor muscle strength and electromyography value in the observation group were higher than those in the control group (P<0.05), while the PFDI-20 score was lower than that in the control group (P<0.05). At 1 month and 3 months after intervention, the I-QOL scores in all domains in the observation group were higher than those in the control group (P<0.05). 【Conclusion】 In elderly women with SUI, the implementation of health belief model nursing combined with biofeedback electrical stimulation treatment can effectively improve urinary incontinence conditions and urodynamic indices, thereby enhancing pelvic floor function and improving patients' quality of life. 2026 Vol. 43 (2): 224-227 [Abstract] ( 8 ) HTML (1 KB)  PDF (1165 KB)  ( 1 ) 228 Diagnostic Value of MSCT Post-Processing Technology in Orbital Traumatic Fractures TONG Shuai, LI Hao, NIU Dongju DOI: 10.3969/j.issn.1671-7171.2026.02.014 【Objective】 To explore the diagnostic value of multi-slice spiral CT (MSCT) post-processing technology in orbital traumatic fractures. 【Methods】 A total of 98 patients with orbital traumatic fractures admitted to our hospital from January 2023 to January 2025 were selected. All patients underwent routine CT examination (control group) and MSCT post-processing technology (observation group). Taking the surgical results as the gold standard, the diagnostic value and diagnostic accuracy of the two examination methods for fracture location and fracture type were compared. 【Results】 The total detection rate of orbital superior wall fracture, orbital inferior wall fracture, orbital medial wall fracture and lateral wall fracture in the observation group was higher than that in the control group, with a statistically significant difference (χ2=4.955, P<0.05). The total detection rate of complete fracture, incomplete fracture, comminuted fracture and fracture end displacement in the observation group was significantly higher than that in the control group, with a statistically significant difference (χ2=8.393, P<0.05). The diagnostic accuracy of MSCT post-processing technology for fracture location and fracture type was significantly higher than that of routine CT, with a statistically significant difference (P<0.05). 【Conclusion】 MSCT post-processing technology can significantly improve the detection rate and diagnostic accuracy of orbital traumatic fracture location and type, which has important clinical application value. 2026 Vol. 43 (2): 228-230 [Abstract] ( 9 ) HTML (1 KB)  PDF (1145 KB)  ( 1 ) 231 Application Effect of Care Plan Based on Stress and Stress Theory in Patients Undergoing Unilateral Total Knee Arthroplasty SUN Qian, ZHAO Shuping, CHAI Xiuwen DOI: 10.3969/j.issn.1671-7171.2026.02.015 【Objective】 To explore the application effect of a care plan based on stress and stress theory in patients undergoing unilateral total knee arthroplasty (TKA). 【Methods】 A total of 88 patients undergoing unilateral total knee arthroplasty admitted to our hospital from January 2022 to December 2024 were selected and divided into the observation group and the control group according to the random number table method, with 44 cases in each group. The control group received routine perioperative nursing, while the observation group received a care plan based on stress and stress theory. The serological indicators [cortisol (COR), adrenocorticotropic hormone (ACTH)] at 48 hours after operation, knee joint function [Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score], emotional state [Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS)], and quality of life [36-Item Short Form Health Survey (SF-36)] at 3 months after operation were compared between the two groups. 【Results】 At 48 hours after operation, the levels of COR and ACTH in the observation group were lower than those in the control group, with statistically significant differences (P<0.05). At 3 months after operation, the scores of WOMAC, SAS and SDS in the observation group were lower than those in the control group, and the SF-36 score was higher than that in the control group, with statistically significant differences (P<0.05). 【Conclusion】 The care plan based on stress and stress theory can effectively reduce the perioperative stress response of patients undergoing unilateral total knee arthroplasty, improve the postoperative knee joint function, alleviate negative emotions, and improve the quality of life, which has good clinical application value. 2026 Vol. 43 (2): 231-234 [Abstract] ( 8 ) HTML (1 KB)  PDF (1168 KB)  ( 1 ) 235 Application Value of Artificial Intelligence Post-Processing Technology in the Diagnosis of Intracranial Aneurysms by Cranial CTA ZHANG Ying, SUN Shuang DOI: 10.3969/j.issn.1671-7171.2026.02.016 【Objective】 To investigate the application value of artificial intelligence (AI) post-processing technology in the diagnosis of intracranial aneurysms by cranial CT angiography (CTA). 【Methods】 A total of 128 patients with intracranial aneurysms who underwent cranial CTA examination in our hospital from January 2023 to May 2025 were selected. Image reconstruction and analysis were performed using traditional manual post-processing and AI-assisted post-processing, respectively. Digital subtraction angiography (DSA) results were used as the gold standard. The differences between the two groups in post-processing time, subjective image quality score, aneurysm neck width, maximum aneurysm diameter, and diagnostic efficacy were compared. Kappa test was used to evaluate the consistency between the AI group and the DSA gold standard. 【Results】 The AI processing time was significantly shorter than the manual processing time, and the difference was statistically significant (t=87.362, P<0.05). The AI image quality score was slightly higher than that of manual processing, but the difference was not statistically significant (P>0.05). Consistency analysis results showed that: the consistency of aneurysm neck width measurement in the small aneurysm group detected by AI was poor (ICC value = 0.216); the consistency in the medium aneurysm group was moderate (ICC value=0.479); the consistency in the large aneurysm group was high (ICC value = 0.855). The consistency of maximum diameter measurement in the small aneurysm group detected by AI was poor (ICC value = 0.277); the consistency in the medium aneurysm group was moderate (ICC value = 0.543); the consistency in the large aneurysm group was high (ICC value = 0.891). Kappa analysis showed that the diagnostic consistency between AI and DSA in the small aneurysm group was moderate (Kappa = 0.531); in the medium aneurysm group, it showed good consistency (Kappa = 0.873); in the large aneurysm group, it reached complete consistency (Kappa = 1.00). 【Conclusion】 Artificial intelligence post-processing technology can significantly shorten the post-processing time of cranial CTA images, improve the detection capability of intracranial aneurysms, and effectively optimize image quality. It is an efficient and reliable auxiliary diagnostic method. 2026 Vol. 43 (2): 235-238 [Abstract] ( 8 ) HTML (1 KB)  PDF (1167 KB)  ( 0 ) 239 Clinical Efficacy of Thoracoscopic Segmentectomy in Elderly Patients with Stage Ⅰ Lung Cancer WANG Daomeng, PAN Zhong, HE Xiaoyong DOI: 10.3969/j.issn.1671-7171.2026.02.017 【Objective】 To investigate the efficacy of thoracoscopic segmentectomy in elderly patients with stage Ⅰ non-small cell lung cancer (NSCLC).【Methods】 A total of 123 patients with stage Ⅰ NSCLC who underwent surgical treatment were enrolled and divided into a lobectomy group (n=47, thoracoscopic lobectomy) and a segmentectomy group (n=76, thoracoscopic segmentectomy). Intraoperative and postoperative outcomes, as well as pulmonary function at 3 and 6 months after surgery, were compared between the two groups. 【Results】 The segmentectomy group had significantly less intraoperative blood loss, shorter postoperative chest tube drainage duration, and shorter hospital stay than the lobectomy group, while the operative time of the observation group was longer than that of the control group (all P<0.05). There was no significant difference in postoperative complication rates between the two groups (P>0.05). No cases of recurrence, metastasis, or death were observed during follow-up at 3 and 6 months after surgery in both groups. At both 3 and 6 months postoperatively, pulmonary function parameters in the segmentectomy group were significantly better than those in the lobectomy group (P<0.05). 【Conclusion】 Thoracoscopic segmentectomy and lobectomy provide comparable safety and oncologic outcomes in elderly patients with stage Ⅰ NSCLC. However, segmentectomy offers greater minimally invasive advantages, including reduced intraoperative blood loss, faster postoperative recovery, and better short-term preservation of pulmonary function. Therefore, it is worthy of wider clinical application. 2026 Vol. 43 (2): 239-241 [Abstract] ( 7 ) HTML (1 KB)  PDF (1146 KB)  ( 0 ) 242 Clinical Efficacy of Clostridium Butyricum Dual Live Bacteria Powder Combined with Double-Sided Blue Light Therapy in the Treatment of Neonatal Hyperbilirubinemia HUO Zhifang, ZHOU Chuan, SONG Huanqing, LI Jingjing, FENG Xiaoxia DOI: 10.3969/j.issn.1671-7171.2026.02.018 【Objective】 To explore the clinical efficacy of Clostridium Butyricum Dual Live Bacteria Powder combined with double-sided blue light therapy in the treatment of neonatal hyperbilirubinemia. 【Methods】 The clinical data of 107 neonates with hyperbilirubinemia admitted to our hospital from February 2020 to February 2023 were retrospectively analyzed. According to different clinical treatment methods, the neonates were divided into the observation group (n=54) and the control group (n=53). Neonates in the control group received routine treatment and double-sided blue light therapy, while those in the observation group received Clostridium Butyricum Dual Live Bacteria Powder treatment on the basis of the control group. The clinical efficacy, laboratory indicators [total bilirubin (TBiL), procalcitonin (PCT), apolipoprotein M (APOM), C-reactive protein (CRP), CD4+, CD8+, CD4+/CD8+, as well as immunoglobulins (IgG, IgA, IgM)], and the incidence of adverse reactions were compared between the two groups. 【Results】 After treatment, the serum TBiL level of neonates in both groups was significantly lower than that before treatment, and the observation group was lower than the control group, with a statistically significant difference (P<0.05). The total effective rate of the observation group was 88.89% (48/54), which was significantly higher than 66.04% (35/53) of the control group, with a statistically significant difference (χ2=8.027, P<0.05). After treatment, the serum CRP, APOM and PCT levels in both groups were lower than those before treatment, and the observation group was lower than the control group, with statistically significant differences (P<0.05). After treatment, IgG, IgA, IgM, CD4+ and CD4+/CD8+ of neonates in both groups were significantly higher than those before treatment, and CD8+ was lower than that before treatment; moreover, IgG, IgA, IgM, CD4+ and CD4+/CD8+ in the observation group were higher than those in the control group, and CD8+ was lower than that in the control group, with statistically significant differences (P<0.05). The incidence of adverse reactions in the observation group was 3.70% (2/54), which was significantly lower than 18.87% (10/53) in the control group, with a statistically significant difference (P<0.05). 【Conclusion】 It is suggested that Clostridium Butyricum Dual Live Bacteria Powder combined with double-sided blue light therapy has a good clinical efficacy in the treatment of neonatal hyperbilirubinemia, which can significantly reduce the serum TBiL level, improve immune function indicators, alleviate inflammatory response, and has high safety. 2026 Vol. 43 (2): 242-245 [Abstract] ( 8 ) HTML (1 KB)  PDF (1175 KB)  ( 0 ) 246 Comparison of Clinical Efficacy among Vitapex Apexification, MTA and iRoot BP Plus Apical Barrier Techniques in the Treatment of Young Permanent Teeth with Apical Periodontitis YAN Chunhua, HUANG Chunya, LI Xiaoqing DOI: 10.3969/j.issn.1671-7171.2026.02.019 【Objective】 To compare the clinical efficacy of Vitapex apexification with MTA and iRoot BP Plus apical barrier techniques in the treatment of young permanent teeth with apical periodontitis. 【Methods】 A total of 103 patients (103 affected teeth) with chronic apical periodontitis of young permanent teeth who visited our hospital from June 2021 to May 2024 were selected. According to different treatment methods, they were divided into Vitapex group (34 patients, 34 affected teeth, treated with Vitapex apexification), MTA group (33 patients, 33 affected teeth, treated with mineral trioxide aggregate MTA apical barrier technique), and iRoot BP Plus group (36 patients, 36 affected teeth, treated with bioceramic material iRoot BP Plus apical barrier technique). The overall clinical effective rates at 1, 3, 6, and 12 months after surgery were compared among the three groups. Additionally, root growth and development, average number of treatment sessions, and average treatment duration were compared before and after treatment among the three groups. 【Results】 At 6 and 12 months after surgery, the overall clinical effective rates in MTA group and iRoot BP Plus group were higher than those in Vitapex group, and the overall clinical effective rate in iRoot BP Plus group was higher than that in MTA group, with statistically significant differences (P<0.05). According to X-ray follow-up examinations, root lengthening and apical foramen closure in Vitapex group at 1 year after surgery were superior to those in MTA group and iRoot BP Plus group, with statistically significant differences (all P<0.05). The average number of treatment sessions in MTA group and iRoot BP Plus group was fewer than that in Vitapex group, and the average treatment duration was significantly shorter than that in Vitapex group, with statistically significant differences (all P<0.05). 【Conclusion】 MTA and iRoot BP Plus apical barrier techniques demonstrate better clinical efficacy than Vitapex apexification in the treatment of young permanent teeth with chronic apical periodontitis, with shorter treatment duration and fewer follow-up visits. However, Vitapex apexification shows greater advantages in promoting continued root development and apical foramen closure. 2026 Vol. 43 (2): 246-249 [Abstract] ( 9 ) HTML (1 KB)  PDF (1176 KB)  ( 0 ) 250 The Effect of Catheter-Directed Thrombolysis Combined with Intravenous Thrombolysis on Thromboelastogram Parameters, Thrombus Clearance and Detumescence Effect in Patients with Lower Extremity Deep Venous Thrombosis JIANG Baohua, JIN Lei, ZHANG Shasha DOI: 10.3969/j.issn.1671-7171.2026.02.020 【Objective】 To explore the effect of catheter-directed thrombolysis (CDT) combined with intravenous thrombolysis (IVT) on thromboelastogram (TEG) parameters, thrombus clearance and detumescence effect in patients with lower extremity deep venous thrombosis (DVT). 【Methods】 A total of 59 patients with lower extremity DVT admitted to our hospital from January 2021 to January 2025 were selected and divided into the observation group (n=30) and the control group (n=29) according to the random number table method. The control group was treated with simple intravenous thrombolysis, while the observation group was treated with catheter-directed thrombolysis combined with intravenous thrombolysis. The thrombus clearance rate, TEG parameters before and after treatment, detumescence effect and venous patency were compared between the two groups. 【Results】 After treatment, the coagulation reaction time (R), coagulation formation time (K) of the observation group were significantly shorter than those of the control group, and the maximum amplitude (MA) and coagulation angle (α angle) were significantly higher than those of the control group, with statistically significant differences (P<0.05). The thrombus clearance rate of the observation group was 93.33% (28/30), which was significantly higher than 86.21% (25/29) of the control group, and the difference was statistically significant (P<0.05). After treatment, the venous patency score of the observation group was significantly lower than that of the control group, the thigh circumference and calf circumference were significantly smaller than those of the control group, and the detumescence rate of the thigh and calf was significantly higher than that of the control group (P<0.05). 【Conclusion】 Catheter-directed thrombolysis combined with intravenous thrombolysis in the treatment of lower extremity DVT can effectively improve the thrombus clearance rate, improve the patient's coagulation function and venous patency, enhance the detumescence effect, and has good safety, which is worthy of clinical promotion and application. 2026 Vol. 43 (2): 250-253 [Abstract] ( 13 ) HTML (1 KB)  PDF (1172 KB)  ( 2 ) 254 Effects of Different Doses of Metoprolol Tartrate Combined with Basic Treatment on Cardiac Function and Heart Rate Variability in Elderly Patients with Conventional Hypertension and Heart Failure SUN Yanpeng, ZHU Yinchuan DOI: 10.3969/j.issn.1671-7171.2026.02.021 【Objective】 To investigate the effects of different doses of metoprolol tartrate combined with basic treatment on cardiac function and heart rate variability in elderly patients with hypertension and heart failure. 【Methods】 A retrospective analysis was conducted on the clinical data of 104 elderly patients with hypertension and heart failure admitted to two hospitals from June 2022 to February 2025. According to the different dosages of metoprolol tartrate administered, patients were divided into a low-dose group (conventional anti-heart failure basic treatment regimen + low-dose metoprolol tartrate) and a high-dose group (conventional anti-heart failure treatment regimen + high-dose metoprolol tartrate), with 52 cases in each group. The clinical efficacy, blood pressure [systolic blood pressure (SBP), diastolic blood pressure (DBP)], heart rate (HR), laboratory indicators [brain natriuretic peptide (BNP), high-sensitivity C-reactive protein (hs-CRP)], cardiac function indicators [left ventricular end-diastolic dimension (LVEDD), left ventricular ejection fraction (LVEF), left ventricular end-systolic dimension (LVESD)], heart rate variability indicators [standard deviation of the average normal-to-normal intervals for all 5-minute segments over 24 hours (SDANN), root mean square of successive differences between adjacent normal-to-normal intervals (RMSSD), standard deviation of all normal-to-normal intervals over 24 hours (SDNN)], and adverse reactions were compared between the two groups. 【Results】 The total effective rate in the high-dose group was 92.31% (48/52), which was higher than 75.00% (39/52) in the low-dose group, and the difference was statistically significant (χ2=4.500, P<0.05). After treatment, HR, SBP, and DBP in both groups were lower than before treatment, and those in the high-dose group were lower than in the low-dose group, with statistically significant differences (P<0.05). Serum BNP and hs-CRP levels in both groups were lower than before treatment, and those in the high-dose group were lower than in the low-dose group, with statistically significant differences (P<0.05). LVESD and LVEDD in both groups were lower than before treatment, while LVEF was higher than before treatment; moreover, LVESD and LVEDD in the high-dose group were lower than in the low-dose group, and LVEF was higher than in the low-dose group, with statistically significant differences (P<0.05). SDANN, SDNN, and RMSSD in both groups were higher than before treatment, and those in the high-dose group were higher than in the low-dose group, with statistically significant differences (P<0.05). There was no statistically significant difference in the total incidence of adverse reactions between the high-dose group and the low-dose group (P>0.05). 【Conclusion】 High-dose metoprolol tartrate can better improve cardiac function, heart rate, blood pressure, and heart rate variability indicators in elderly patients with hypertension and heart failure. Its efficacy is superior to that of low-dose, with good safety, and it is worthy of clinical promotion and application. 2026 Vol. 43 (2): 254-257 [Abstract] ( 11 ) HTML (1 KB)  PDF (1176 KB)  ( 1 ) 258 Diagnostic Value of Fundus Fluorescein Angiography Combined with Optical Coherence Tomography in Diabetic Retinopathy ZHANG Bingqi, WANG Wenling, HU Xiuhui DOI: 10.3969/j.issn.1671-7171.2026.02.022 【Objective】 To investigate the diagnostic value of fundus fluorescein angiography (FFA) combined with optical coherence tomography (OCT) in diabetic retinopathy (DR). 【Methods】 A total of 125 patients (250 eyes) with suspected DR admitted to our hospital from August 2022 to August 2024 were selected. All patients underwent FFA and OCT examinations. Clinical diagnostic results were used as the gold standard. The diagnostic value of FFA, OCT, and combined examination in DR was compared. The retinal nerve fiber layer (RNFL) thickness in patients with proliferative diabetic retinopathy (PDR) and non-proliferative diabetic retinopathy (NPDR) was also compared. 【Results】 Among the 125 patients (250 eyes), 180 eyes were clinically diagnosed with DR. FFA examination detected DR in 152 eyes, OCT examination detected DR in 156 eyes, and combined examination detected DR in 174 eyes. The sensitivity, specificity, and accuracy of combined examination for diagnosing DR were 97.14%, 96.80%, and 96.67%, respectively, all of which were superior to any single examination. The RNFL thickness in the superior, inferior, temporal, and nasal quadrants in PDR patients was thinner than that in NPDR patients (P<0.05). 【Conclusion】 FFA combined with OCT can significantly improve the sensitivity, specificity, and accuracy of DR diagnosis. The RNFL thickness in PDR patients is thinner than that in NPDR patients. Combined examination can provide important basis for early diagnosis and staging of DR. 2026 Vol. 43 (2): 258-260 [Abstract] ( 11 ) HTML (1 KB)  PDF (1146 KB)  ( 0 ) 261 Effect of Meropenem De-Escalation Therapy on Pulmonary Function and CPIS Score in Elderly Patients with Respiratory Failure Complicated by Pulmonary Infection CUI Xiaoqing DOI: 10.3969/j.issn.1671-7171.2026.02.023 【Objective】 To investigate the effect of meropenem de-escalation therapy on pulmonary function and clinical pulmonary infection score (CPIS) in elderly patients with respiratory failure complicated by pulmonary infection. 【Methods】 A total of 97 elderly patients with respiratory failure complicated by pulmonary infection admitted to our Hospital from August 2022 to August 2024 were enrolled. According to the treatment methods, they were divided into a conventional treatment group (n=48) and a meropenem group (n=49). The conventional group received standard antibiotic therapy, while the meropenem group was treated with meropenem de-escalation therapy. Clinical efficacy, pulmonary function, arterial blood gas parameters, Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ) scores, CPIS scores, and biomarker levels were compared between the two groups. 【Results】 The treatment efficacy in the meropenem group was significantly higher than that in the conventional group (P<0.05). After treatment, the meropenem group showed significantly higher forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), and peak expiratory flow (PEF) than the conventional group (P<0.05). Arterial oxygen partial pressure (PaO2) and oxygenation index (OI) were also higher in the meropenem group, while arterial carbon dioxide partial pressure (PaCO2) was lower (P<0.05). The APACHE Ⅱ and CPIS scores in the meropenem group were significantly lower than those in the conventional group (P<0.05). Additionally, serum levels of procalcitonin (PCT), pentraxin-3 (PTX3), and high mobility group box protein 1 (HMGB1) in the meropenem group were significantly lower than those in the conventional group (P<0.05). 【Conclusion】 Meropenem de-escalation therapy has a significant impact on improving pulmonary function and reducing CPIS scores in elderly patients with respiratory failure complicated by pulmonary infection. 2026 Vol. 43 (2): 261-264 [Abstract] ( 8 ) HTML (1 KB)  PDF (1171 KB)  ( 0 ) 265 The Effect of Sacubitril/Valsartan Sodium Combined with Dapagliflozin on Cardiac Function in Patients with Coronary Heart Disease Complicated with Chronic Heart Failure WANG Xiumei, ZHUANG Yu DOI: 10.3969/j.issn.1671-7171.2026.02.024 【Objective】 To explore the effect of sacubitril/valsartan sodium combined with dapagliflozin on cardiac function in patients with coronary heart disease (CHD) complicated with chronic heart failure (CHF). 【Methods】 A total of 118 patients with CHD complicated with CHF admitted to our hospital from January 2021 to December 2024 were selected and divided into the control group and the observation group by random number table method, with 59 cases in each group. The control group took sacubitril/valsartan sodium orally on the basis of routine treatment, while the observation group took dapagliflozin orally on the basis of the control group. The blood lipid levels [high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG)], cardiac function [left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), left ventricular ejection fraction (LVEF)], myocardial injury markers [creatine kinase isoenzyme (CK-MB), cardiac troponin T (cTnT), B-type natriuretic peptide (BNP)], vascular endothelial function [flow-mediated dilation (FMD), endothelin (ET), nitric oxide (NO)], and plaque indicators [carotid intima-media thickness (IMT), plaque thickness, plaque area] were compared between the two groups before and after treatment, and the occurrence of adverse reactions in patients was recorded.【Results】 After treatment, the serum levels of TC, TG and LDL-C in both groups were lower than those before treatment, and the HDL-C level was higher than that before treatment; moreover, the serum levels of TC, TG and LDL-C in the observation group were lower than those in the control group, and the HDL-C level was higher than that in the control group, with statistically significant differences (P<0.05). The LVEDD and LVESD in both groups were lower than those before treatment, and the LVEF was higher than that before treatment; moreover, the LVEDD and LVESD in the observation group were lower than those in the control group, and the LVEF was higher than that in the control group, with statistically significant differences (P<0.05). The serum levels of cTnT, BNP and CK-MB in both groups were lower than those before treatment, and the observation group was lower than the control group, with statistically significant differences (P<0.05). The FMD and NO in both groups were higher than those before treatment, and ET was lower than that before treatment; moreover, the FMD and NO in the observation group were higher than those in the control group, and ET was lower than that in the control group, with statistically significant differences (P<0.05). The IMT, plaque thickness and plaque area in both groups were lower than those before treatment, and the observation group was lower than the control group, with statistically significant differences (P<0.05). The total incidence of adverse reactions in the observation group was lower than that in the control group, with a statistically significant difference (P<0.05). 【Conclusion】 Sacubitril/valsartan sodium combined with dapagliflozin can improve the vascular endothelial function, cardiac function and blood lipid levels of patients with CHD complicated with CHF, reduce myocardial injury, and has good safety. 2026 Vol. 43 (2): 265-268 [Abstract] ( 10 ) HTML (1 KB)  PDF (1180 KB)  ( 0 ) 269 Influencing Factors Analysis of Non-Suicidal Self-Injury Behavior in Adolescent Depression Patients GUO Bei, DUAN Bo, LI Haigen DOI: 10.3969/j.issn.1671-7171.2026.02.025 【Objective】 To explore the related influencing factors of non-suicidal self-injury (NSSI) in adolescent depression patients. 【Methods】 A retrospective analysis was conducted on the clinical data of 120 adolescent depression patients admitted to our hospital from June 2022 to June 2025. Patients were divided into a non-self-harm /suicidal behavior group (n=68) and an NSSI group (n=52) based on whether they had NSSI. Sociodemographic data, disease history, psychological assessment results, and life event records were collected from the two groups of patients. Logistic regression model was used to analyze potential risk factors affecting NSSI occurrence, and a prediction model was constructed based on these factors. 【Results】 The scores of neuroticism and psychoticism in the NSSI group were higher than those in the group without self-harm/suicide behavior, and the difference was statistically significant (P<0.05). There was no statistically significant difference (P>0.05) in the comparison of internal and external tendencies and concealment scores between the two groups. The Hamilton Depression Rating Scale 24 (HAMD-24), Childhood Abuse Questionnaire (CTQ), and Adolescent Life Events Scale (ASLEC) scores of the NSSI group were significantly higher than those of the group without self-harm/suicide behavior, and the Self Esteem Scale (SES) scores in the NSSI group were lower than those of the group without self-harm/suicide behavior, with statistical significance (P<0.05). The NSSI group scored higher than the group without self-harm/suicide behavior in terms of paternal rejection, maternal rejection, maternal emotional warmth, and maternal overprotection, and the difference was statistically significant (P<0.05). Logistic regression analysis showed that neuroticism, psychoticism, HAMD-24 score, CTQ score, paternal rejection, and ASLEC score were related factors affecting the occurrence of NSSI in adolescent depression patients (P<0.05). 【Conclusion】 Factors such as personality traits, degree of depression, early life events, and family environment are all closely related to the occurrence of NSSI in adolescents with depression. It is recommended that when treating adolescents with depression, these psychological and social factors should be comprehensively considered. Thus, corresponding intervention measures should be taken to reduce the occurrence of NSSI. 2026 Vol. 43 (2): 269-272 [Abstract] ( 9 ) HTML (1 KB)  PDF (1231 KB)  ( 0 ) 273 Predictive Value of Thoracoabdominal Artery CTA Imaging Combined with Serum D-Dimer Level for Prognosis of Non-Obese Patients with Aortic Dissection LIANG Zhihua, WANG Xiaolong, TAI Shengqi DOI: 10.3969/j.issn.1671-7171.2026.02.026 【Objective】 To analyze the predictive value of thoracoabdominal artery computed tomography angiography(CTA) imaging combined with serum D-dimer (D-D) level for the prognosis of non-obese patients with aortic dissection. 【Methods】 The clinical data of 89 non-obese patients with aortic dissection admitted to our hospital from March 2021 to February 2024 were retrospectively analyzed. According to the patients' survival status during hospitalization, they were divided into the poor prognosis group (death, n=17) and the good prognosis group (survival, n=72). The baseline data, CTA examination results and serum D-D levels were compared between the two groups. The influencing factors of prognosis in non-obese patients with aortic dissection and the predictive efficacy of CTA score combined with serum D-D level for the prognosis of these patients were analyzed. 【Results】 The proportion of Stanford type A, the proportion of CTA score of 3 and 4, systolic blood pressure and serum D-D level in the poor prognosis group were all higher than those in the good prognosis group, with statistically significant differences (P<0.05). Multivariate Logistic regression analysis showed that Stanford classification, systolic blood pressure, CTA score and serum D-D level were all influencing factors for the prognosis of non-obese patients with aortic dissection (P<0.05). ROC curve analysis showed that the area under the curve (AUC) of CTA score combined with serum D-D level in predicting the prognosis of non-obese patients with aortic dissection was 0.968, which was significantly higher than that of a single index (P<0.05). 【Conclusion】 CTA score combined with serum D-D level has high efficacy in evaluating the prognosis of non-obese patients with aortic dissection. Clinicians can predict the prognosis of patients according to their CTA score and serum D-D level, and take effective measures in a timely manner. 2026 Vol. 43 (2): 273-276 [Abstract] ( 9 ) HTML (1 KB)  PDF (1193 KB)  ( 0 ) 277 Application Effect of Emergency Optimization Intervention Based on Shared Decision-Making Model in Severe Trauma Patients YAO Bing, YANG Piao, JIANG Jianzhao, ZHAO Li DOI: 10.3969/j.issn.1671-7171.2026.02.027 【Objective】 To explore the application effect of emergency optimization intervention based on shared decision-making model in severe trauma patients. 【Methods】 A total of 120 severe trauma patients admitted to our hospital from February 2022 to February 2025 were selected and divided into control group and observation group according to random number table method, with 60 cases in each group. The control group received routine emergency nursing intervention, while the observation group received emergency optimization intervention based on shared decision-making model on the basis of routine emergency nursing intervention. The emergency effect, emergency time and satisfaction were compared between the two groups. 【Results】 The effective rate of emergency treatment in the observation group was 93.3% (56/60), which was higher than 80.0% (48/60) in the control group, and the difference was statistically significant (χ2=4.615, P=0.032). The first examination time, emergency department stay time, and time from emergency department to trauma operating room in the observation group were shorter than those in the control group, and the differences were statistically significant (P<0.05). The scores of nursing attitude, nursing content, nursing process and nursing outcome in the observation group were higher than those in the control group, and the differences were statistically significant (P<0.05).【Conclusion】 The emergency optimization intervention based on shared decision-making model has good application effect in severe trauma patients, which can significantly improve the emergency efficiency and nursing satisfaction of patients. 2026 Vol. 43 (2): 277-279 [Abstract] ( 10 ) HTML (1 KB)  PDF (1142 KB)  ( 2 ) 280 Application Effect of Family Collaborative Cognitive Intervention Combined with Psychological Support in Pregnant Women with Threatened Abortion ZHANG Huixia, DING Mengxia, ZHANG Wen DOI: 10.3969/j.issn.1671-7171.2026.02.028 【Objective】 To explore the application effect of family collaborative cognitive intervention combined with psychological support in pregnant women with threatened abortion. 【Methods】 A prospective trial was conducted. A total of 386 pregnant women with threatened abortion who were diagnosed and treated in our hospital from January 2021 to January 2024 were selected and divided into the control group and the observation group by random number table method, with 193 cases in each group. The control group received family collaborative cognitive intervention, while the observation group received family collaborative cognitive intervention combined with psychological support. The psychological status [Self-Rating Anxiety Scale (SAS) score, Self-Rating Depression Scale (SDS) score], sleep quality [Pittsburgh Sleep Quality Index (PSQI) score], occurrence of clinical symptoms and incidence of adverse pregnancy outcomes were compared between the two groups. 【Results】 After intervention, the SAS, SDS and PSQI scores of both groups were significantly lower than those before intervention (P<0.05), and the observation group was lower than the control group (P<0.05). The incidence of clinical symptoms such as lumbar pain, lower abdominal pain, vaginal bleeding and bloody secretion in the observation group was significantly lower than that in the control group (P<0.05). The incidence of adverse pregnancy outcomes in the observation group was significantly lower than that in the control group (P<0.05). 【Conclusion】 Family collaborative cognitive intervention combined with psychological support can effectively improve the psychological status, sleep quality and clinical symptoms of pregnant women with threatened abortion, and reduce the risk of adverse pregnancy outcomes, which is of great significance for optimizing the overall pregnancy experience of pregnant women with threatened abortion. 2026 Vol. 43 (2): 280-283 [Abstract] ( 8 ) HTML (1 KB)  PDF (1167 KB)  ( 0 ) 284 Efficacy of Evolocumab Combined with Atorvastatin in the Treatment of Symptomatic Intracranial Atherosclerotic Stenosis MAO Zhenya, CHEN Jiansu DOI: 10.3969/j.issn.1671-7171.2026.02.029 【Objective】 To investigate the efficacy of evolocumab combined with atorvastatin in the treatment of patients with symptomatic intracranial atherosclerotic stenosis (ICAS). 【Methods】 A total of 116 patients with symptomatic ICAS were randomly divided into the control group and the observation group, with 58 cases in each group. The control group was treated with atorvastatin calcium tablets, while the observation group was administered with evolocumab in addition to the control group's regimen. The blood lipid levels, carotid intima-media thickness (CIMT), plaque thickness, serum amyloid A1 (SAA1), cerebral blood volume (CBV) and cerebral blood flow (CBF) before and after treatment, as well as the incidence of adverse reactions during medication were compared between the two groups. The incidence of adverse endpoint events such as recurrent cerebral infarction, restenosis and death within 1 year after treatment was recorded. 【Results】 After treatment, the blood lipid metabolism level in the observation group was significantly improved compared with that in the control group. The levels of CIMT, plaque thickness and serum SAA1 in the observation group were lower than those in the control group, while CBV and CBF were higher than those in the control group (P<0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). The incidence of adverse endpoint events in the observation group was lower than that in the control group (P<0.05). 【Conclusion】 Evolocumab combined with atorvastatin can more effectively improve the blood lipid profile, carotid artery lesions and cerebral blood flow status of patients with symptomatic ICAS safely. It reduces the incidence of adverse endpoint events. 2026 Vol. 43 (2): 284-286 [Abstract] ( 9 ) HTML (1 KB)  PDF (1148 KB)  ( 0 )

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