导管接触性溶栓联合静脉溶栓对下肢深静脉血栓形成患者血栓弹力图参数、血栓清除效果及消肿效果的影响

doi:10.3969/j.issn.1671-7171.2026.02.020

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Abstract 【Objective】 To explore the effect of catheter-directed thrombolysis (CDT) combined with intravenous thrombolysis (IVT) on thromboelastogram (TEG) parameters, thrombus clearance and detumescence effect in patients with lower extremity deep venous thrombosis (DVT). 【Methods】 A total of 59 patients with lower extremity DVT admitted to our hospital from January 2021 to January 2025 were selected and divided into the observation group (n=30) and the control group (n=29) according to the random number table method. The control group was treated with simple intravenous thrombolysis, while the observation group was treated with catheter-directed thrombolysis combined with intravenous thrombolysis. The thrombus clearance rate, TEG parameters before and after treatment, detumescence effect and venous patency were compared between the two groups. 【Results】 After treatment, the coagulation reaction time (R), coagulation formation time (K) of the observation group were significantly shorter than those of the control group, and the maximum amplitude (MA) and coagulation angle (α angle) were significantly higher than those of the control group, with statistically significant differences (P<0.05). The thrombus clearance rate of the observation group was 93.33% (28/30), which was significantly higher than 86.21% (25/29) of the control group, and the difference was statistically significant (P<0.05). After treatment, the venous patency score of the observation group was significantly lower than that of the control group, the thigh circumference and calf circumference were significantly smaller than those of the control group, and the detumescence rate of the thigh and calf was significantly higher than that of the control group (P<0.05). 【Conclusion】 Catheter-directed thrombolysis combined with intravenous thrombolysis in the treatment of lower extremity DVT can effectively improve the thrombus clearance rate, improve the patient's coagulation function and venous patency, enhance the detumescence effect, and has good safety, which is worthy of clinical promotion and application.

Key words： Venous Thrombosis Lower Extremity Mechanical Thrombolysis Thrombolytic Therapy Thrombelastography

Received: 26 September 2025

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R459.7

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	JIANG Baohua
	JIN Lei
	ZHANG Shasha

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JIANG Baohua,JIN Lei,ZHANG Shasha. The Effect of Catheter-Directed Thrombolysis Combined with Intravenous Thrombolysis on Thromboelastogram Parameters, Thrombus Clearance and Detumescence Effect in Patients with Lower Extremity Deep Venous Thrombosis[J]. JOURNAL OF CLINICAL RESEARCH, 2026, 43(2): 250-253.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2026.02.020 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2026/V43/I2/250

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