沙库巴曲缬沙坦钠联合达格列净对冠心病合并慢性心力衰竭患者心功能的影响

doi:10.3969/j.issn.1671-7171.2026.02.024

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Abstract 【Objective】 To explore the effect of sacubitril/valsartan sodium combined with dapagliflozin on cardiac function in patients with coronary heart disease (CHD) complicated with chronic heart failure (CHF). 【Methods】 A total of 118 patients with CHD complicated with CHF admitted to our hospital from January 2021 to December 2024 were selected and divided into the control group and the observation group by random number table method, with 59 cases in each group. The control group took sacubitril/valsartan sodium orally on the basis of routine treatment, while the observation group took dapagliflozin orally on the basis of the control group. The blood lipid levels [high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG)], cardiac function [left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), left ventricular ejection fraction (LVEF)], myocardial injury markers [creatine kinase isoenzyme (CK-MB), cardiac troponin T (cTnT), B-type natriuretic peptide (BNP)], vascular endothelial function [flow-mediated dilation (FMD), endothelin (ET), nitric oxide (NO)], and plaque indicators [carotid intima-media thickness (IMT), plaque thickness, plaque area] were compared between the two groups before and after treatment, and the occurrence of adverse reactions in patients was recorded.【Results】 After treatment, the serum levels of TC, TG and LDL-C in both groups were lower than those before treatment, and the HDL-C level was higher than that before treatment; moreover, the serum levels of TC, TG and LDL-C in the observation group were lower than those in the control group, and the HDL-C level was higher than that in the control group, with statistically significant differences (P<0.05). The LVEDD and LVESD in both groups were lower than those before treatment, and the LVEF was higher than that before treatment; moreover, the LVEDD and LVESD in the observation group were lower than those in the control group, and the LVEF was higher than that in the control group, with statistically significant differences (P<0.05). The serum levels of cTnT, BNP and CK-MB in both groups were lower than those before treatment, and the observation group was lower than the control group, with statistically significant differences (P<0.05). The FMD and NO in both groups were higher than those before treatment, and ET was lower than that before treatment; moreover, the FMD and NO in the observation group were higher than those in the control group, and ET was lower than that in the control group, with statistically significant differences (P<0.05). The IMT, plaque thickness and plaque area in both groups were lower than those before treatment, and the observation group was lower than the control group, with statistically significant differences (P<0.05). The total incidence of adverse reactions in the observation group was lower than that in the control group, with a statistically significant difference (P<0.05). 【Conclusion】 Sacubitril/valsartan sodium combined with dapagliflozin can improve the vascular endothelial function, cardiac function and blood lipid levels of patients with CHD complicated with CHF, reduce myocardial injury, and has good safety.

Key words： Coronary Disease Heart Failure Chronic Disease Valsartan Drug Therapy, Combination

Received: 05 June 2025

PACS:

R542.22

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	WANG Xiumei
	ZHUANG Yu

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WANG Xiumei,ZHUANG Yu. The Effect of Sacubitril/Valsartan Sodium Combined with Dapagliflozin on Cardiac Function in Patients with Coronary Heart Disease Complicated with Chronic Heart Failure[J]. JOURNAL OF CLINICAL RESEARCH, 2026, 43(2): 265-268.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2026.02.024 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2026/V43/I2/265

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