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Quick Search     Adv Search 2023 Vol. 40, No. 1 Published: 2023-01-26 Review and lecture Original Articles          Original Articles 4 Relationship of Serum 5-HT,DA and NE with Depression Severity in Patients with Breast Cancer after Chemotherapy JIAO De-sheng, CHANG Han-feng DOI: 10.3969/j.issn.1671-7171.2023.01.002 【Objective】 To investigate the relationship of serum serotonin (5-HT),dopamine (DA) and norepinephrine (NE) with the severity of depression in breast cancer patients after chemotherapy.【Methods】 Sixty patients who underwent adjuvant chemotherapy with depression after radical mastectomy in two hospitals were selected as the observation group; And 60 patients who received adjuvant chemotherapy without depression after radical mastectomy were selected as the control group.Serum 5-HT,DA,and NE levels were measured in both groups.Patients in the depression group were analyzed hierarchically according to the Self-rating Depression Scale (SDS) score.Then the relationship of depression severity with 5-HT,DA and NE were analyzed.【Results】 Serum 5-HT,DA and NE levels in the depression group were significantly lower than those in the control group (P<0.05).Serum 5-HT,DA and NE levels in patients with severe or moderate depression were lower than those in the mild group (P<0.05); And serum 5-HT,DA and NE levels in patients with severe depression were lower than those in the moderate group (P<0.05).After treatment, serum levels of 5-HT,DA and NE were significantly higher than those before treatment (P<0.05).There was a significant negative correlation of serum 5-HT,DA and NE levels with SDS scores in patients with depression receiving postoperative chemotherapy (P<0.05).【Conclusion】 Serum 5-HT,DA and NE levels were significantly lower in patients with depression while receiving adjuvant chemotherapy after radical mastectomy.There was a good correlation of depression severity with 5-HT,DA and NE levels. 2023 Vol. 40 (1): 4-6 [Abstract] ( 102 ) HTML (1 KB)  PDF (1111 KB)  ( 72 ) 7 Changes of Plasma NO,ET,ANP,PRA and AT in Patients with Chronic Renal Failure before and after Dialysis SHEN Hong-liang, LUO Yong DOI: 10.3969/j.issn.1671-7171.2023.01.003 【Objective】 To investigate the changes and clinical value of plasma nitric oxide(NO),endothelin(ET),artial natriuretic polypeptide(ANP),renin activity(PRA) and angiotensin(AT) in patients with chronic renal failure(CRF) before and after dialysis.【Methods】 The patients with chronic renal failure and healthy people in our hospital were selected as the research subjects.There were 40 cases in the CRF group and 40 cases in the control group.The levels of plasma NO,ET,ANP,PRA and AT were measured before and after dialysis.Healthy volunteers in the control group received all measurements as well.The changes of indexes were compared between the CRF group and the control group; And they were also compared before and after dialysis in the CRF group.【Results】 The levels of plasma NO,ET,ANP,PRA and AT in the CRF group were significantly higher than those in the normal control group (P<0.05).Compared to before dialysis,plasma NO and ANP levels were significantly lower in the CRF group after dialysis (P<0.05),while levels of plasma PRA and AT were significantly higher (P<0.05).There was no significant difference in plasma ET level of the CRF group before and after dialysis (P>0.05).【Conclusion】 Hemodialysis treatment can lead to a decrease in plasma NO and ANP levels,an increase in PRA and AT levels,and a slight decrease in ET level,which indicate changes of plasma NO,ET,ANP,PRA,and AT levels in patients with chronic renal failure during hemodialysis.However,the impact of changes among those indicators is more complicated.In clinical application,it is necessary to refer to the specific diagnosis of each indicator. 2023 Vol. 40 (1): 7-9 [Abstract] ( 78 ) HTML (1 KB)  PDF (1109 KB)  ( 51 ) 10 Effects of Different Anesthesia Methods on Hemodynamics,Cerebral Oxygen Metabolism and Pain-causing Substances in Living Donor Liver Transplantation Patients LI Chao, ZHU Hong-kuan, CHEN Yong-lun DOI: 10.3969/j.issn.1671-7171.2023.01.004 【Objective】 To analyze the effects of different anesthesia methods on hemodynamics,cerebral oxygen metabolism and pain-causing substances in living donor liver transplantation (LDLT) patients.【Methods】 A total of 112 LDLT patients admitted to our hospital were selected in this study.According to the random number table method,patients were divided into the sevoflurane group ( anesthesia with sevoflurane,n=56) and the isoflurane group ( anesthesia with isoflurane,n=56).The changes of hemodynamic indexes [heart rate (HR) and mean arterial pressure (MAP)] and cerebral oxygen extraction rate (CO2ER) and jugular venous blood oxygen saturation (SjvO2) were compared between the two groups before operation,before anhepatic phase,35 min in anhepatic phase,30 min in neohepatic phase,2 h in neohepatic phase,and 12 h in neohepatic phase.Changes of pain-causing substances [substance P (SP) and 5-hydroxytryptamine (5-HT) in serum] at 12 h and 24 h after surgery in the two groups of patients were compared between the two groups as well.The adverse reactions of the two groups of patients in the perioperative period were recorded.【Results】 There were no significant differences in HR,MAP,CO2ER and SjvO2 between the sevoflurane group and the isoflurane group before surgery and 12 h in neohepatic phase (P>0.05).From pre-anhepatic phase to 2 h in neohepatic phase,HR and SjvO2 in the sevoflurane group were lower than those in the isoflurane group (P<0.05),and MAP and CO2ER in the sevoflurane group were higher than those in the isoflurane group (P<0.05).At 24 h after surgery,serum SP and 5-HT levels in both sevoflurane group and isoflurane group were higher than those in both groups at 12 h after surgery (P<0.05).Serum SP and 5-HT levels in the sevoflurane group were lower than those in the isoflurane group at 12 h and 24 h after surgery (P<0.05).There was no significant difference in the incidence of perioperative adverse reactions between two groups (P>0.05).【Conclusion】 Compared to the way of anesthesia with isoflurane,method of anesthesia with sevoflurane has less effect on perioperative hemodynamics and cerebral oxygen metabolism in LDLT patients,and it can significantly inhibit the level of postoperative pain-causing substances,which is safe and worthy of clinical promotion and application. 2023 Vol. 40 (1): 10-13 [Abstract] ( 64 ) HTML (1 KB)  PDF (1133 KB)  ( 54 ) 14 Clinicopathologic Features of Gastric Adenocarcinoma with Gastrointestinal Stromal Tumor in Xinjiang Area YU Jing, XU Bao-qun, YE Ming,et al DOI: 10.3969/j.issn.1671-7171.2023.01.005 【Objective】 To evaluate the clinicopathologic features of adenocarcinoma with gastrointestinal stromal tumor (GIST) in the stomach. 【Methods】 The clinical data of 703 gastric cancer (GC) patients (546 Han, 122 Uygur, and 35 Hui) admitted to the Third Clinical Medical College of Xinjiang Medical University (Affiliated Tumor Hospital) were collected. Clinicopathologic features of 16 cases of adenocarcinoma with gastrointestinal stromal tumor (GIST) from those 703 cases of gastric cancer were analyzed. 【Results】 Among 703 gastric cancer patients, 16 cases (2.28%) of GIST with synchronous carcinoma were diagnosed preoperatively, including 12 males and 4 females. The age of the patients ranged from 35 to 80 years old (average age 63.5 years old). All cases were invasive adenocarcinoma of no special type,which mean diameter was 4.6 cm. Meanwhile, 16 cases of GISTs were single nodule in the stomach, with an average diameter of 0.96 cm; And the histomorphological examinations all showed spindle cell type. Most GISTs were in the early phase and had low risk of malignance:14 cases were of very low risk, 1 case of low risk, and 1 case of moderate risk. The positive rate of CD117 and SDH-B proteins expression were 100%, Dog-1 were 87.5% (14/16), CD34 were 75% (12/16), the Ki-67 proliferative index was lower than 5%. The mutation detection rate of C-KIT exons 11 and 9 were 56.25% (9/16),18.75% (3/16), respectively, while 4 cases were no mutations. There were no correlated with different ethnic groups in adenocarcinoma with GIST in the stomach(P>0.05). All the patients with gastric cancer were undernent radical gastrectomy. At a median follow-up of 29 months,10 cases were alive without evidence of recurrence or distant metastases, whereas 3 cases had gastric adenocarcinoma distant metastases. 【Conclusion】 In our study, there is no difference of incidence rate among nationalities . There is no high risk grading in synchronous GIST,and no patients have GIST relapse. The cytologically of all GIST cases are bland spindle shaped cells. Decisions about surgical extent and further management should likely be made mainly according to GC in the occurrence synchronous tumors. 2023 Vol. 40 (1): 14-16 [Abstract] ( 59 ) HTML (1 KB)  PDF (1812 KB)  ( 50 ) 17 Diagnostic Value of Rectal Ultrasound Combined with Serum WISP1 and CHI3L1 in Prostate Cancer JI Jie, ZHANG Ya-nan, CHEN Hai-bing DOI: 10.3969/j.issn.1671-7171.2023.01.006 【Objective】 To investigate the diagnostic value of transrectal ultrasound combined with serum Wnt1 inducible signal pathway protein 1 (WISP1) and chitinase class 3 protein 1 (CHI3L1) in prostate cancer.【Methods】 A total of 100 patients with prostate cancer (prostate cancer group) and 82 patients with benign prostatic hyperplasia (control group) diagnosed and treated in our hospital from July 2018 to July 2020 were selected. The patients in both groups were examined by transrectal ultrasound. The expression levels of serum WISP1 and CHI3L1 were detected by real-time fluorescence quantitative PCR. The diagnostic value of transrectal ultrasound combined with the expression levels of serum WISP1 and CHI3L1 in prostate cancer was analyzed. 【Results】 The expression levels of serum WISP1 and CHI3L1 in the prostate cancer group were 1.43±0.30 and 1.67±0.36, respectively, which were significantly higher than those in the control group (1.02±0.22 and 1.19±0.23, respectively, P<0.05). The analysis of the ROC curve of the subjects showed that the area under the curve of WISP1 and CHI3L1 alone in diagnosing prostate cancer was 0.870 and 0.815 respectively, the specificity was 84.15% and 85.37% respectively, and the sensitivity was 80.00% and 72.00% respectively; The sensitivity and specificity of transrectal ultrasound in the diagnosis of prostate cancer were 70.00% and 81.71% respectively, which were in good agreement with the clinical gold standard (Kappa=0.509, P<0.05). The sensitivity and specificity of transrectal ultrasound combined with serum WISP1 and CHI3L1 in the diagnosis of prostate cancer were 69.00% and 96.34% respectively, which were in good agreement with the clinical gold standard (Kappa=0.634, P<0.05). 【Conclusion】 The specificity of transrectal ultrasound combined with serum WISP1 and CHI3L1 in the diagnosis of prostate cancer is higher than that of single examination, and it has a higher diagnostic value in early prostate cancer. 2023 Vol. 40 (1): 17-20 [Abstract] ( 56 ) HTML (1 KB)  PDF (1165 KB)  ( 83 ) 21 Analysis of Therapeutic Results and Related Factors of 208 Children with Ametropic Amblyopia XIANG Jian-bo, GUO Yan, YANG Jun-fang,et al DOI: 10.3969/j.issn.1671-7171.2023.01.007 【Objective】 To summarize the therapeutic effect of ametropic amblyopia in children and explore the related factors affecting the therapeutic effect of ametropic amblyopia in children. 【Methods】 A total of 208 children with ametropic amblyopia who were admitted to the Department of Ophthalmology of Hunan Children's Hospital from March 2019 to March 2021 were enrolled, and their age, gender, amblyopia degree, refractive nature and vision recovery with different treatment methods were collected. According to age, sex, refractive property, amblyopia degree and treatment methods, the relevant factors of efficacy were statistically analyzed. 【Results】 The overall effective rate of the 386 eyes in 208 children was 89.64% (346/386). The total effective rate of treatment in the 3~5 year-old group of children was 97.95%, higher than that 85.37% of the 6~8 year-old group and 73.53% of the 9~12 year-old group. The difference was statistically significant (P<0.05). The total effective rate of treatment in male children was 89.32%,while 90.13% wasin women children; There was no statistically significant difference (P>0.05). The total effective rate of children with hyperopia treatment was 95.09%, which was significantly higher than of children with mixed astigmatism (89.13%) and children with myopic children (79.31%). The differences were statistically significant (P<0.05). The treatment effective rate in children with mild amblyopia was 96.05%, which was also significantly higher than in children with moderate amblyopia (90.22%) and in children with severe amblyopia (68.00%); And the differences were statistically significant (P<0.05).The total effective rate was 94.57% for children with ametropia error who received comprehensive treatment, which was significantly higher than 77.27% for children who received regular refractive correction. The difference was statistically significant (P<0.05). 【Conclusion】 The therapeutic effect of ametropic amblyopia in children is closely related to various factors such as age, refractive properties, degree of amblyopia, training methods and different treatments. Clinically, symptomatic treatment should be adopted as early as possible according to the specific conditions of children to improve the therapeutic effect. 2023 Vol. 40 (1): 21-23 [Abstract] ( 73 ) HTML (1 KB)  PDF (1110 KB)  ( 84 ) 24 CT Perfusion Imaging in Evaluating the Degree of Craniocerebral Injury and its Predictive Value for Cerebral Hemodynamics after ICP Probe Implantation DU Yan-ting, DU Guang-yong, JIA Zhe,et al DOI: 10.3969/j.issn.1671-7171.2023.01.008 【Objective】 To evaluate the degree of craniocerebral injury by CT perfusion imaging and its predictive value for cerebral hemodynamics after ICP probe implantation. 【Methods】 A total of 79 patients with craniocerebral injury (observation group) admitted to our hospital from January 2016 to December 2020 were selected, including 25 mild patients, 21 moderate patients and 33 severe patients. In addition, 79 patients (control group) were selected for physical examination at the same time. The levels of regional cerebral blood flow (rCBF), regional cerebral blood volume (rCBV) and mean time of blood passing through tissues (MTT) were compared between the observation group and the control group, patients with different severity and patients with different therapeutic effects. ROC curve was used to analyze the predictive value of rCBF, rCBV and MTT in the severity of brain injury and the therapeutic effect. 【Results】 The rCBF and rCBV in the observation group were significantly lower than those in the control group, and the MTT was significantly higher than that in the control group (P<0.05). The rCBF and rCBV of the mild group, the moderate group and the severe group showed a gradual increase trend, while MTT showed a downward trend, and the difference between the groups was statistically significant (P<0.05). The rCBF and rCBV of patients in the effective group were higher than those in the ineffective group, and the MTT was lower than those in the ineffective group (P<0.05). ROC curve analysis showed that the area under the prediction curve of the severity of brain injury and the therapeutic effect of the combined detection of rCBF, rCBV and MTT was significantly higher than that of the single detection (P<0.05). 【Conclusion】 CT perfusion imaging has high specificity in the diagnosis of brain injury and cerebral hemodynamics after ICP probe implantation, which is worthy of clinical application. 2023 Vol. 40 (1): 24-27 [Abstract] ( 53 ) HTML (1 KB)  PDF (1132 KB)  ( 73 ) 28 Correlation between Serum Uric acid Level and Osteoporosis in Newly Diagnosed Elderly Male Patients with Type 2 Diabetes ZHONG Ru-yi, CHEN Sheng, HU Fang-lin DOI: 10.3969/j.issn.1671-7171.2023.01.009 【Objective】 To investigate the correlation between serum uric acid level and osteoporosis in newly diagnosed elderly male type 2 diabetes patients. 【Methods】 A total of 200 elderly male patients with type 2 diabetes who were newly diagnosed in our hospital from March 2020 to July 2022 were selected. The bone mineral density (BMD) values of all patients were measured by dual energy X-ray absorptiometry. According to the BMD values of patients, they were divided into non osteoporosis group (n=144) and osteoporosis group (n=56). The age, body mass index (BMI), blood uric acid and other indicators of patients were collected, and the correlation between each indicator and BMD value was analyzed. 【Results】 Compared with the non osteoporosis group, the patients in the osteoporosis group had lower BMI, blood uric acid, limb skeletal muscle mass index (ASM), limb skeletal muscle mass index (ASMI), and BMD values of each part (P<0.05). BMI, blood uric acid, ASM, and ASMI were positively correlated with BMD of each site (P<0.05). Multiple logistic regression analysis showed that low BMI and low ASMI were independent risk factors for osteoporosis in newly diagnosed elderly male patients with type 2 diabetes, and serum uric acid was a protective factor (P=0.0171).【Conclusion】 The newly diagnosed elderly male type 2 diabetes patients with normal or slightly higher levels of blood uric acid can effectively prevent osteoporosis, and blood uric acid can be used as an important indicator for screening osteoporosis patients. 2023 Vol. 40 (1): 28-30 [Abstract] ( 89 ) HTML (1 KB)  PDF (1111 KB)  ( 105 ) 31 Clinical Effects of Timing Herbal Foment on Qi-Deficiency and Blood Stasis Patients with Post-stroke Shoulder-hand Syndrome (Stage Ⅰ) ZHANG Zhu-ping, ZHONG Wen, PANG Lin,et al DOI: 10.3969/j.issn.1671-7171.2023.01.010 【Objective】 To observe the clinical effects of timing herbal foment in the treatment of patients with Qi-deficiency and blood stasis type of post-stroke shoulder-hand syndrome (stage Ⅰ). 【Methods】 A total of 80 patients with post-stroke shoulder-hand syndrome in stage I who were admitted to the Department of Encephalopathy in our hospital from May 2020 to October 2021.They were selected and randomly divided into the observation group and the control group, with 40 cases in each group. The control group was treated with routine nursing and rehabilitation training. The observation group was treated with timing herbal foment in addition to the control group. After continuous observation for 3 weeks, modified Fugl Meyer upper limb motor function score (FMA), the Changhai pain scale and activities of daily living score of the two groups were compared. 【Results】 Compared the effects of treatment in the two groups before treatment, the FMA score increased and the Changhai pain scale decreased after treatment; And the differences were significant (P<0.05). There was no difference in FMA and Changhai Pain Scale scores between the two groups before treatment (P>0.05).After treatment, the FMA score of the observation group was higher than that of the control group, while the score of Changhai pain sacle was lower than that of the control group. There were significant difference (P<0.05). The total clinical effective rate of the observation group was higher than that of the control group (P<0.05). During the treatment, no adverse reactions such as rash, itching, blisters, and ulceration occurred in the two groups of patients. 【Conclusion】 Timing herbal foment can effectively improve the limb motor function and reduce pain in patients with Qi-deficiency and blood stasis type of post-stroke shoulder-hand syndrome (stage Ⅰ). Thus, it improves the clinical efficacy, which is suitable for clinical comprehensive treatment. 2023 Vol. 40 (1): 31-33 [Abstract] ( 49 ) HTML (1 KB)  PDF (1108 KB)  ( 82 ) 34 Effects of Etanercept on Neuronal Apoptosis and Expression of Fas and Caspase-8 in Rats with Diabetes Retinopathy WANG Kun, ZHANG Li-hua, GAN Xue-feng,et al DOI: 10.3969/j.issn.1671-7171.2023.01.011 【Objective】 To investigate the effect of etanercept on neuronal apoptosis and the expression of Fas and caspase-8 in diabetes retinopathy (DR) rats. 【Methods】 A total of 30 SPF SD rats were randomly divided into control group, model group and etanercept group with 10 rats in each group. After DR modeling of rats in the etanercept group was successful, 0.4 mg/kg etanercept solution was subcutaneously injected into the front thigh once a day for 8 weeks; The control group and the model group were intraperitoneally injected with 0.01 mol/L citric acid sodium citrate buffer solution of the same pH 4.5 at the same time. After drug intervention, apoptosis of retinal neurons in each group was detected by in situ terminal labeling (TUNEL), and apoptosis index (AI) was calculated; The activity of superoxide dismutase (SOD) and the levels of reactive oxygen species (ROS) and malonaldehyde (MDA) in serum were measured; The levels of Fas and caspase-8 protein in the retina of rats in each group were detected by Western blot. 【Results】 Apoptosis appeared in neurons of the model group and the etanercept group. Compared with the control group, the activity of AI in neuron cells, the activity of SOD in serum, and the levels of Fas and caspase-8 protein in retina of rats in the model group and the etanercept group increased (P<0.05), while the levels of MDA and ROS in serum decreased (P<0.05); The AI of nerve cells, the activity of SOD in serum, the level of Fas and caspase-8 protein in retinal tissue of rats in the etanercept group were lower than those in the model group (P<0.05), and the levels of MDA and ROS in serum were higher than those in the model group (P<0.05). 【Conclusion】 Etanercept may inhibit the activation of Fas/caspase-8 pathway by inhibiting the oxidative stress response of neurons in DR rats, thereby inhibiting neuronal apoptosis. 2023 Vol. 40 (1): 34-36 [Abstract] ( 60 ) HTML (1 KB)  PDF (1259 KB)  ( 48 ) 37 Study on the Relationship between the Expression of Mismatch Repair Protein and Ki67 Protein and Progression Free Survival after Colorectal Cancer Resection in the Elderly DANG Li-li, LI Jin DOI: 10.3969/j.issn.1671-7171.2023.01.012 【Objective】 To investigate the relationship between the expression of mismatch repair protein and Ki67 protein and progression free survival (PFS) after resection of colorectal cancer (CRC) in the elderly. 【Methods】 From October 2016 to October 2021, 96 elderly patients with CRC who underwent radical resection of colorectal cancer in Hanzhong Central Hospital were selected, and colorectal cancer tissue specimens and adjacent tissues were collected. The expression of mismatch repair protein and Ki67 protein in cancer tissues and adjacent tissues were compared.The expression of mismatch repair protein and Ki67 protein in colorectal cancer tissues and adjacent tissues were compared. The correlation between the expression of mismatch repair protein and Ki67 protein in cancer tissues and their clinicopathological characteristics was analyzed. Cox regression analysis was used to analyze the related factors affecting the prognosis of elderly CRC patients, and to analyze the correlation between the expression of mismatch repair protein and Ki67 protein and PFS in elderly CRC patients after radical surgery. 【Results】 The negative expression rate of mismatch repair protein and the positive expression rate of Ki67 protein in colorectal cancer tissues were higher than those in adjacent tissues (P<0.05). The negative expression rate of mismatch repair protein and the positive expression rate of Ki67 protein in the cancer tissues of elderly CRC patients with different tumor diameter, clinical stage, lymph node metastasis, degree of differentiation and depth of invasion were statistically significant (all P<0.05). Ninety six elderly patients with CRC were followed up for 3 years, 3 patients were lost, and 21 of the remaining 93 patients (22.58%) died. Cox regression analysis showed that tumor diameter, clinical stage, lymph node metastasis, degree of differentiation, negative expression of mismatch repair protein and positive expression of Ki67 protein were independent factors affecting the prognosis of elderly CRC patients (P<0.05). The survival curve of patients with positive expression of mismatch repair protein was significantly different from that of patients with negative expression (P<0.05). The survival curve of patients with negative Ki67 protein expression was significantly different from that of patients with positive Ki67 protein expression (P<0.05). 【Conclusion】 The expression rate of mismatch repair protein (MRP) is negative and Ki67 protein is positive in elderly CRC patients. The expressions of MRP and Ki67 protein are correlated with the clinicopathological characteristics and prognosis of the patients. 2023 Vol. 40 (1): 37-40 [Abstract] ( 63 ) HTML (1 KB)  PDF (1155 KB)  ( 25 ) 41 Analysis of MRI-DWI and DCE-MRI Sequence in the Diagnosis of Focal Nodular Lesions under the Background of Fatty Liver YUAN Hai-jun, ZENG Ming DOI: 10.3969/j.issn.1671-7171.2023.01.013 【Objective】 To explore the diagnostic value of MRI diffusion weighted imaging (MRI-DWI) and dynamic enhanced magnetic resonance imaging (DCE-MRI) sequences for focal nodular lesions under the background of fatty liver. 【Methods】 A total of 118 patients with fatty liver complicated with focal nodular lesions who were admitted to our hospital from April 2019 to October 2021 were selected as the research objects. All patients underwent MRI-DWI and DCE-MRI examinations. The pathological diagnosis was considered as the gold standard for diagnosis. The apparent diffusion coefficient (ADC) values of patients with different focal nodular lesions were analyzed. The DCE-MRI scan parameters of patients with different focal nodular lesions were compared. The time-signal curve types of patients with different focal nodular lesions were analyzed as well. The diagnostic efficiency and consistency of MRI-DWI and DCE-MRI were analyzed. 【Results】 There were 51 cases of malignant nodules and 67 cases of benign nodules in 118 patients. The ADC scores of different b values in the malignant nodule group were lower than those in the benign nodule group (P<0.05). The peak value (PV), maximum ascending slope (MSI), and maximum descending slope (MSD) of the malignant nodule group were lower than those of the control group (P<0.05), while the Kep, Ktrans and Ve values of the malignant nodule group were higher than those of the control group (P<0.05). When types of the time-signal curve were compared between the malignant nodule group and the benign nodule group, the difference was statistically significant (P<0.05). The sensitivities of MRI-DWI, DCE-MRI and their combination measurement for diagnosis of focal nodular lesions in the context of fatty liver were 94.12%, 96.08% and 94.12%, respectively; While the specificities of them were 91.04%, 89.55%, and 100.00%, respectively. The consistent Kappa values of pathological diagnosis with MRI-DWI, DCE-MRI or MRI-DWI+MRI diagnosis of focal nodular lesions in patients with fatty liver were 0.808, 0.815, 0.824, respectively. 【Conclusion】 The parameters of MRI-DWI and DCE-MRI in patients with focal nodular lesions under the background of fatty liver are related to the nature of the lesions. MRI combined with DWI and DCE sequences can improve the diagnostic efficiency of focal nodular lesions in the background of fatty liver. 2023 Vol. 40 (1): 41-44 [Abstract] ( 51 ) HTML (1 KB)  PDF (1132 KB)  ( 87 ) 45 Correlation of Prognosis in Patients with Primary Liver Cancer to DC-SIGN,TACC3 and BMP4 Expression in Tissues HOU Zhi-gang, LIU Zhen-hui DOI: 10.3969/j.issn.1671-7171.2023.01.014 【Objective】 To investigate the prognostic factors of patients with primary liver cancer (PLC).【Methods】 A total of 90 PLC patients were divided into the death group (40 cases) and the survival group (50 cases) according to the three-year prognosis.The basic data and laboratory indicators of the two groups of patients [optical density value of dendritic cell specific intercellular adhesion molecule-3 binding non integrin (DC-SIGN),bone morphogenetic protein 4 (BMP4) level,and positive rate of transcription associated acid curl protein 3 (TACC3)] were collected and compared.DC-SIGN optical density value,TACC3 level and BMP4 positive rate were analyzed by ROC curve to predict the poor prognosis of PLC patients.Unconditional logistic stepwise regression analysis was used to identify the risk factors for poor prognosis of PLC patients.【Results】 The proportion of bilobular tumor distribution,alcohol drinking history,lymph node invasion or distant metastasis,TNM stage Ⅲ-Ⅳ in the death group were significantly higher than those in the survival group (P<0.05),whose DC-SIGN optical density,TACC3 level and BMP4 positive rate were significantly higher than those in the survival group (P<0.05).ROC analysis showed that DC-SIGN optical density ≥10.925×10-3/μm2,TACC3 level ≥331.494 ng/g,and BMP4 positive rate ≥79.883% were the cut-off values for predicting poor prognosis of PLC patients (all P<0.05),respectively.Logistic stepwise regression analysis showed that the bilobular tumor distribution,history of alcohol consumption,lymph node invasion or distant metastasis,TNM stage Ⅲ-Ⅳ,DC-SIGN optical density ≥10.925×10-3/μm2,TACC3 level ≥331.494 ng/g and positive rate of BMP4 ≥79.883% were risk factors for poor prognosis in PLC patients (P<0.05).【Conclusion】 Tumor distribution,drinking history,lymph node invasion,distant metastasis,TNM stage,DC-SIGN optical density value,TACC3 level,BMP4 positive rate were closely related to the prognosis of PLC patients. 2023 Vol. 40 (1): 45-48 [Abstract] ( 64 ) HTML (1 KB)  PDF (1210 KB)  ( 77 ) 49 Imaging Characteristics of Splenic Lymphatic Malformation in Children MA Qiu-hong, CAI Qi-fang, YI Ting,et al DOI: 10.3969/j.issn.1671-7171.2023.01.015 【Objective】 Investigate the imaging features of splenic lymphatic malformation in children. 【Methods】 The clinical data of 9 children with splenic lymphatic malformation confirmed by pathological examination from January 2010 to December 2020 in Hunan Children's Hospital were analyzed retrospectively. Eight patients were performed plain CT scan and enhancement in our hospital, and one patient was performed plain CT scan and enhancement in our hospital. The location, classification, shape, boundary, size, calcification, separation, density/signal and enhancement mode of splenic lymphatic malformation were observed and analyzed. 【Results】 Three cases were located under the splenic capsule, 6 cases were located around and deep in the spleen; Pathological examination showed that 4 cases were giant cysts, 3 cases were microcapsules, and 2 cases were mixed; 3 cases were lobulated, 6 cases were round in size; The boundary of 3 cases was blurred, and the boundary of 6 cases was still clear, including 1 case of single lesion with small point calcification at the edge. On plain CT scan, 7 cases showed low density shadow, 1 case showed slightly high density shadow, and the microcystic type showed "honeycomb" changes. On enhanced CT scans, 6 cases showed slight enhancement of the septum and cyst wall, 1 case showed slight enhancement of the center and edge of the lesion, 1 case showed obvious uneven enhancement of the solid part, 1 case showed slightly longer T1 and slightly longer T2 signals, and the enhanced solid part showed progressive enhancement. 【Conclusion】 The splenic lymphatic malformation in children presents single or multiple lesions, and its CT and MRI manifestations have certain characteristics. Most of them present low density shadow or cystic signal, and a few of them have uneven density or signal, calcification can be seen in the cystic wall, and the septa and cystic wall have slight enhancement, while the solid part can have uneven enhancement or progressive enhancement, which is helpful for the diagnosis of splenic lymphatic malformation. 2023 Vol. 40 (1): 49-52 [Abstract] ( 62 ) HTML (1 KB)  PDF (2143 KB)  ( 102 ) 53 Effects of Thalidomide Combined with Precise Radiotherapy and Chemotherapy on Serum miR-451 and miR-21 Levels and Prognosis in Patients with Esophageal Cancer WANG Li-yan, LIU Xiao-xia DOI: 10.3969/j.issn.1671-7171.2023.01.016 【Objective】 To investigate the effect of thalidomide combined with precise radiotherapy and concurrent chemotherapy on serum microrRNA-451 (miR-451) and microrRNA-21 (miR-21) levels and prognosis in patients with esophageal cancer.【Methods】 A total of 96 patients with esophageal cancer were randomly divided into two groups,with 48 cases in each group.The control group was given precise radiotherapy combined with concurrent chemotherapy,while the observation group was given thalidomide combined with precise radiotherapy and chemotherapy.After 2 months of treatment,the short-term efficacy,incidence of adverse reactions,serum levels of carcinoembryonic antigen (CEA),carbohydrate antigen 125 (CA125),macrophage inflammatory protein-3α(MIP-3α),miR-451,miR-21 and follow-up results were compared between the two groups before and after treatment.【Results】 The disease remission rate of the observation group was 70.83%,which was significantly higher than that of the control group (50.00%,P<0.05).The incidence of radiation esophagitis and hematotoxicity in the observation group was significantly lower than that in the control group (P<0.05).There was no significant difference in the incidence of radiation bronchitis,esophageal stenosis and pulmonary fibrosis between the two groups (P>0.05).After treatment,the serum levels of CEA,CA125,MIP-3α,miR-451 and miR-21 in the two groups were significantly lower than those before treatment (P<0.05),and the observation group was significantly lower than the control group (P<0.05).The 3-year cumulative survival rate of the observation group was 58.70%,which was significantly higher than that of the control group (33.33%) (P<0.05).【Conclusion】 Compared with precise radiotherapy and concurrent chemotherapy,thalidomide combined with precise radiotherapy and concurrent chemotherapy has more accurate short-term and long-term efficacy in the treatment of esophageal cancer.It can lower the level of tumor markers and serum miR-451,miR-21 levels,and reduce the risk of radiation esophagitis and blood toxicity. 2023 Vol. 40 (1): 53-56 [Abstract] ( 52 ) HTML (1 KB)  PDF (1129 KB)  ( 90 ) 57 Effect of Pelvic Floor Magnetic Stimulation Combined with Traditional Chinese Medicine Physiotherapy on Urine Leakage and Pelvic Floor Muscle Tension in Patients with Stress Urinary Incontinence LIU Fen-qin, SHANG Hui, XU Hong-ying DOI: 10.3969/j.issn.1671-7171.2023.01.017 【Objective】 To investigate the effect of pelvic floor magnetic stimulation combined with traditional Chinese medicine physical therapy on urine leakage and pelvic floor muscle tension in patients with stress urinary incontinence (SUI). 【Methods】 A total of 86 SUI patients admitted to Yan'an People's Hospital were randomly divided into observation group and control group with 43 patients in each group. The control group was treated with pelvic floor muscle magnetic stimulation, and the observation group was treated with traditional Chinese medicine warm acupuncture on the basis of the control group. The clinical efficacy, urine leakage (urine leakage volume in 1 hour urine pad test, urine leakage frequency in 3 days), recurrence, pelvic floor muscle strength, quality of life score, and urodynamic parameters (maximum urine leakage point pressure, initial urinary bladder capacity) were compared between the two groups. 【Results】 After treatment, the total effective rate of the observation group was 88.37%, which was significantly higher than that of the control group (69.77%, P<0.05); The pelvic floor muscle strength, pelvic floor class Ⅰ muscle voltage, pelvic floor class Ⅱ muscle voltage and QOL score measured by hand in the observation group were significantly higher than those in the control group (P<0.05); The fatigue degree of type Ⅰ muscle fiber and type Ⅱ muscle fiber in the pelvic floor, urine leakage volume in one hour urine pad test, urine leakage frequency in three days, maximum urine leakage point pressure, initial urine desire bladder capacity and other urodynamic parameters were significantly lower than those in the control group (P<0.05); Compared with the control group, the recurrence rate of the observation group in the third and sixth months was significantly lower (P<0.05). 【Conclusion】 Pelvic floor magnetic stimulation combined with warm acupuncture and moxibustion has a significant effect on SUI, which can significantly enhance the pelvic floor muscle strength, improve the urodynamic parameters, improve urine leakage and quality of life, and reduce the recurrence rate. 2023 Vol. 40 (1): 57-60 [Abstract] ( 61 ) HTML (1 KB)  PDF (1132 KB)  ( 264 ) 61 Clinical Efficacy of TURBT Combined with Chemotherapy in the Treatment of T2 Myometrial Invasive Bladder Cancer and the Influence on the Levels of Serum DKK and CIP2A ZHOU Ke-bin, LIN Jia-wei, ZHAO Liu-cun DOI: 10.3969/j.issn.1671-7171.2023.01.018 【Objective】 To investigate the clinical efficacy of transurethral resection of bladder tumor (TURBT) combined with chemotherapy in the treatment of T2 myometrial invasive bladder cancer and the influence on the levels of serum Dickkopf protein (DKK) and cancerous inhibitor of protein phosphatase 2A (CIP2A). 【Methods】 The clinical data of 130 patients with T2 myometrial invasive bladder cancer (MIBC) admitted to our hospital from January 2018 to January 2021 were retrospectively analyzed. According to the different treatment methods, they were divided into the observation group (treated with TURBT combined with chemotherapy, n=75) and the control group (treated with open radical cystectomy (ORC, n=55). The operation time, intraoperative blood loss, postoperative catheter indwelling time and surgical complications of the two groups were recorded, and the serum DKK and CIP2A levels of the two groups were compared before and after operation. 【Results】 The bleeding volume, operation time and indwelling catheter time in the observation group were significantly lower than those in the control group (P<0.05). After operation, the levels of serum CEA, CA19-9 and CA125 in the two groups were lower than those before operation, and the levels in the observation group were lower than those in the control group, the difference was statistically significant (P<0.05); The levels of serum DKK and CIP2A in the two groups were lower than those before operation, and those in the observation group were lower than those in the control group, with significant difference (P<0.05). The total incidence of complications in the observation group was lower than that in the control group, with a statistically significant difference (P<0.05). There was no significant difference in the recurrence rate between the observation group and the control group (P>0.05). 【Conclusion】 Compared with ORC operation, TURBT operation can significantly improve the clinical efficacy of bladder cancer patients, reduce the serum DKK and CIP2A levels, and have less trauma. 2023 Vol. 40 (1): 61-63 [Abstract] ( 52 ) HTML (1 KB)  PDF (1112 KB)  ( 52 ) 64 Expression of PAR-1 and PAR-2 in Hirschsprung's Disease and its Correlation with Prognosis JI Yun-feng, HUI Sheng-qi DOI: 10.3969/j.issn.1671-7171.2023.01.019 【Objective】 To investigate the expression of protease activated receptor-1 (PAR-1) and protease activated receptor-2 (PAR-2) in Hirschsprung's disease (HSCR) and their relationship with prognosis. 【Methods】 A total of 100 children with HSCR who received radical surgery in our hospital from January 2014 to January 2019 were selected, and tissue samples of HSCR lesions (spastic segments) and normal intestinal mucosa adjacent to the lesions (more than 2 cm from the lesions) were taken. Immunohistochemistry was used to detect the expression of PAR-1 and PAR-2 in HSCR pathological tissue samples and normal intestinal mucosa tissues. Fluorescent quantitative PCR was used to detect the expression of PAR-1 mRNA and PAR-2 mRNA. Pearson's method was used to analyze the horizontal correlation between PAR-1, PAR-2, Krickenbeck scores, serum IL-6 and TNF-α. Logistic multivariate analysis was used to analyze the risk factors of poor prognosis in children with HSCR. 【Results】 The positive expression rates of PAR-1 and PAR-2 in the pathological tissues were higher than those in the adjacent tissues (P<0.05). Compared with the adjacent tissues, the expression levels of PAR-1 mRNA, PAR-2 mRNA and PAR-1, PAR-2 protein in the diseased tissues were significantly higher (P<0.05); The level of PAR-1, PAR-2 and serum IL-6, TNF-α in children in the poor prognosis group was significantly higher than that of the good prognosis group and the better prognosis group (P<0.05). The good prognosis group was higher than the better prognosis group (P<0.05). Pearson's results showed that PAR-1, PAR-2 were negatively correlated with Krickenbeck's score (P<0.05), and were positively correlated with IL-6 and TNF-α (mean P<0.05). Multivariate logistic regression analysis showed that PAR-1 and PAR-2 were independent risk factors for poor prognosis of children with HSCR (P<0.05). 【Conclusion】 PAR-1 and PAR-2 are highly expressed in HSCR tissues and negatively correlated with Krickenbeck score, which are risk factors for poor prognosis of children with HSCR. 2023 Vol. 40 (1): 64-67 [Abstract] ( 49 ) HTML (1 KB)  PDF (1136 KB)  ( 84 ) 68 Comparison of Retrograde Intrarenal Surgery and Standard Percutaneous Nephrolithotomy in Treatment of Ureteropelvic Junction Stones with High Hydronephrosis SHI Feng, SUN Wen-gong, LIU Zeng-zhen,et al DOI: 10.3969/j.issn.1671-7171.2023.01.020 【Objective】 To compare the efficacy and safety of standard percutaneous nephrolithotomy (PCNL) and retrograde intrarenal surgery (RIRS) in the treatment of ureteropelvic junction stonrs/calculi with high hydronephrosis. 【Methods】 A total of 100 patients with renal pelvic and ureteral junction stones with high hydronephrosis who were treated in our hospital from December 2018 to December 2021 were selected in the study. Patients were divided into the observation group and the control group with 50 cases each, according to the random drawing method. The observation group received PCNL, while the control group received RIRS. The operation time, stone removal rate, hospital stay, postoperative hemoglobin loss rate, anesthesia and analgesia utilization rate, postoperative uremia incidence, complication rate and secondary operation rate were compared between the two groups. 【Results】 The operation time in the observation group was shorter than that in the control group, while the hospitalization time, the postoperative hemoglobin loss were higher than those in the control group (P<0.05). The incidence of uremia in the observation group (2.00%) and the rate of secondary operation were significantly lower than those in the control group(P<0.05).【Conclusion】 RIRS and PCNL are safe and effective methods for the treatment of stones at the junction of the renal pelvis and ureter with high hydronephrosis. PCNL has more advantages in reducing the incidence of postoperative uremia and the rate of secondary operations. 2023 Vol. 40 (1): 68-70 [Abstract] ( 61 ) HTML (1 KB)  PDF (1107 KB)  ( 100 ) 71 Comparison of the Effects of Functional Adsorptive Dentures and Traditional Removable Dentures in the Restoration of Dentition Loss LI Chao-hui DOI: 10.3969/j.issn.1671-7171.2023.01.021 【Objective】 To compare the clinical effects of functional adsorptive denture and traditional removable denture in repairing dentition loss. 【Methods】 From September 2020 to August 2021, 86 patients with dentition loss who underwent complete denture restoration in our hospital were randomly divided into control group (traditional removable denture restoration) and observation group (functional adsorption denture restoration) with 43 cases in each group. The retention and stability scores, masticatory efficiency, comfort, mucosal tenderness points and subjective satisfaction were compared between the two groups. 【Results】 After restoration, the retention and stability scores of maxillary and mandibular dentures in the observation group were higher than those in the control group (P<0.05). Before repair, there was no significant difference in masticatory efficiency and comfort between the two groups (P>0.05); After repair, the masticatory efficiency and comfort of the observation group were higher than those of the control group (P<0.05). On the 3rd and 5th day after repair, the tenderness points of maxillary and mandibular mucosa in the observation group were lower than those in the control group (P<0.05); Three months after repair, the satisfaction of the observation group was higher than that of the control group (P<0.05). 【Conclusion】 Compared with traditional removable dentures, functional adsorption dentures can improve denture retention and stability scores, masticatory efficiency, comfort, reduce mucosal tenderness points, and improve patient satisfaction. 2023 Vol. 40 (1): 71-73 [Abstract] ( 86 ) HTML (1 KB)  PDF (1104 KB)  ( 177 ) 74 Correlation between Serum Periosteal Protein,Hyaluronic Acid and Prognosis of Acute Spontaneous Intracerebral Hemorrhage SUN Ying-hui, ZHAO Xin-chun DOI: 10.3969/j.issn.1671-7171.2023.01.022 【Objective】 To investigate the relationship between serum periosteal protein,hyaluronic acid and the prognosis of acute spontaneous intracerebral hemorrhage (ASICH).【Methods】 A total of 89 patients with ASICH (observation group) and 44 healthy people (control group) were selected as the study objects,and the levels of serum periosteal protein and hyaluronic acid were measured.Pearson was used to analyze the correlation between periosteal protein and hyaluronic acid and NIHSS score,hematoma volume and mRS score.Logistic regression was used to analyze the risk factors of ASICH prognosis,and receiver operating characteristic (ROC) curve was used to evaluate the value of periosteal protein and hyaluronic acid in judging ASICH prognosis.【Results】 The levels of periosteal protein and hyaluronic acid in the observation group were higher than those in the control group (P<0.05).Periosteal protein and hyaluronic acid were positively correlated with NIHSS score,hematoma volume and mRS score.Logistic regression analysis showed that age>65,NIHSS score>12,bleeding volume>28 mL,early neurological deterioration,periosteal protein >287.78 ng/mL and hyaluronic acid > 593.92 ng/mL were all independent risk factors for the prognosis of ASICH.Serum periosteal protein and hyaluronic acid have high prognostic value in patients with ASICH.【Conclusion】 The high levels of serum periosteal protein and hyaluronic acid suggest that patients with ASICH are in serious condition and have an increased risk of poor prognosis. 2023 Vol. 40 (1): 74-77 [Abstract] ( 50 ) HTML (1 KB)  PDF (1289 KB)  ( 42 ) 78 Correlation between Serum High Mobility Group Protein B1, D-dimer Levels and Prognosis in Patients with Acute Traumatic Coagulopathy LI Yu DOI: 10.3969/j.issn.1671-7171.2023.01.023 【Objective】 To investigate the correlation between serum high mobility group B1 (HMGB1), D-dimer (D-D) levels and prognosis in patients with acute traumatic coagulopathy (ATC). 【Methods】 A total of 86 ATC patients (observation group) hospitalized in our hospital from July 2019 to May 2020 were selected and divided into survival group and death group according to the prognosis of ATC patients during hospitalization; In addition, 74 healthy volunteers who were examined in our hospital at the same time were selected as the control group. The serum HMGB1 level was detected by ELISA; Serum D-D and hs-CRP levels were detected by immunoturbidimetry; Prothrombin time (PT), activated partial thromboplastin time (APTT) and platelet count (PLT) were measured by automatic blood coagulation analyzer; The correlation between the levels of HMGB1 and D-D and the indexes of coagulation function and inflammation in patients with ATC was analyzed; The prognostic factors of ATC patients were also analyzed. 【Results】 HMGB1, D-D, PT, APTT, hs-CRP in the observation group were higher than those in the control group, while PLT was lower than that in the control group, with statistical significance (P<0.05); HMGB1 was positively correlated with D-D levels in ATC patients (r=0.594, P<0.05), and positively correlated with PT, APTT, hs-CRP (P<0.05), and negatively correlated with PLT (P<0.05). HMGB1, D-D, PT, APTT, hs-CRP in the death group were higher than those in the survival group, while PLT was lower than those in the survival group, with significant difference (P<0.05); HMGB1 and D-D were independent risk factors for death of ATC patients (P<0.05), and PLT was protective factor for death of ATC patients (P<0.05). 【Conclusion】 The levels of HMGB1 and D-D in patients with ATC are elevated, which has certain significance in predicting the prognosis of patients. 2023 Vol. 40 (1): 78-80 [Abstract] ( 39 ) HTML (1 KB)  PDF (1112 KB)  ( 59 ) 81 The Value of CT Perfusion Imaging Parameters Combined with ABCD2 Score in Predicting Short-term Stroke Risk in TIA Patients ZHAO Shu-ping, WANG Wen-hui, WANG Yan-ping DOI: 10.3969/j.issn.1671-7171.2023.01.024 【Objective】 To investigate the value of CT perfusion imaging (CTP) parameters combined with ABCD2 score in predicting stroke in patients with transient ischemic attack (TIA).【Methods】 A total of 91 TIA patients were divided into stroke group (n=33) and non stroke group (n=58) according to whether stroke occurred 7 days after admission.The general data,low-density cholesterol (LDL-C),high-density cholesterol (HDL-C),thrombomodulin (TM),D-dimer (D-D),fasting blood glucose,ABCD2 score and CTP parameters (cerebral blood volume (CBV),cerebral blood flow (CBF),mean transit time (MTT) and time to peak (TTP) of the two groups were compared.The value of short-term stroke in TIA patients was predicted by analyzing the relevant indicators of the reciever's oprating characteristic curve (ROC),and the risk factors of short-term stroke in TIA patients were identified by multivariate logistic regression analysis.【Results】 There was no significant difference in sex,age,comorbidity,body mass index (BMI),drinking history,LDL-C,HDL-C,CBV and fasting blood glucose between the two groups (P>0.05); The scores of TM,D-D,TTP,MTT and ABCD2 in stroke group were significantly higher than those in non stroke group,and the CBF was significantly lower than that in non stroke group (P<0.05); ROC analysis showed that TM ≥ 28.918 g/L,D-D ≥487.548 mg/L,TTP ≥15.297 s,MTT ≥ 4.340 s,ABCD2 score ≥ 4.632,CBF ≤ 28.313 mL/(100 g·min) were the best cutoff values for predicting stroke in TIA patients in the short term (all P<0.05); Logistic regression analysis showed that the above indicators and data were risk factors for stroke in TIA patients in the short term (P<0.05).【Conclusion】 The occurrence of stroke in TIA patients in the short term is related to TM,D-D,TTP,MTT,CBF,ABCD2 scores,which should be closely monitored. 2023 Vol. 40 (1): 81-84 [Abstract] ( 51 ) HTML (1 KB)  PDF (1136 KB)  ( 47 ) 85 Value of Serum NT-proBNP,H-FABP and VEGF-B in Predicting Coronary Heart Disease and Cardiac Function JING Xiao, YANG Miao-ying DOI: 10.3969/j.issn.1671-7171.2023.01.025 【Objective】 To study the effects of changes in NT-proBNP,H-FABP,and VEGF-B levels on cardiac function in patients with coronary heart disease.【Methods】 Eighty-seven patients with coronary heart disease were selected as the observation group,and 80 healthy subjects were used as the control group.NT-proBNP,H-FABP,VEGF-B,left ventricular end-diastolic volume (LVEDV),left ventricular end-systolic volume (LVESV),left ventricular ejection fraction (LVEF),cardiac output,volume (CO) and cardiac index (CI) were measured before and after treatment in the observation group; And they were compared with the control group.The NYHA cardiac function grading before and after treatment in the observation group were analyzed.【Results】 The levels of NT-proBNP,H-FABP,and VEGF-B in the control group were significantly lower than those in the observation group both before treatment and after treatment.The NT-proBNP,H-FABP and VEGF-B levels in the observation group after treatment were significantly lower than those before treatment (P<0.05).The LVEDV,LVESV,and LVEF levels in the control group were significantly higher than those before treatment and after treatment in the observation group.After treatment,LVEDV,LVESV,and LVEF levels of the observation group were significantly higher than those before treatment.The CO and CI of the control group were significantly higher than those of the observation group.The CO of the observation group after treatment was significantly higher than that before treatment (P<0.05).There were no significant differences in CO and CI between the control group and the observation group (P>0.05).The cardiac function of the observation group after treatment was significantly higher than that before treatment; And the difference was statistically significant (P<0.05).【Conclusion】 Detection of changes in NT-proBNP,H-FABP,and VEGF-B levels can predict the severity of patients with coronary heart disease. 2023 Vol. 40 (1): 85-87 [Abstract] ( 49 ) HTML (1 KB)  PDF (1108 KB)  ( 23 ) 88 Relationship of Plasma ADAMTS13 Level with Disease Activity in Patients with Lupus Nephritis WANG Xiao-yan, HE Ya-feng DOI: 10.3969/j.issn.1671-7171.2023.01.026 【Objective】 To investigate the relationship of ADAMTS13 level (von Willebrand factor lytic protease) with disease activity in patients with lupus nephritis (LN).【Methods】 A total of 100 patients with LN admitted to our hospital from October 2018 to December 2020 were selected as the LN group.According to the systemic lupus erythematosus disease activity index (SLEDAI),patients were divided into the basically inactivity group,mild activity group,moderate activity group and severe activity group.While 100 healthy people in the same period were selected as the control group.Clinical data and blood biochemical indexes were collected.The plasma levels of ADAMTS13,von Willebrand factor (VWF),interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α) were determined.【Results】 Compared with the control group,the levels of triacylglycerol (TG),low density lipoprotein (LDL-C) and uric acid in the systemic lupus erythematosus group were significantly higher (P<0.05),while apoA-1 were significantly lower (P<0.05).Compared to the control group,the levels of plasma ADAMTS13,red blood cells,white blood cells,platelets,hemoglobin,complement C3,C4,and plasma of LN patients in the basically inactive group,mildly active group,moderately active group,and severely active group decreased gradually; And plasma levels of inflammatory factors IL-6,TNF-α,VWF and VWF/ADAMTS13 increased in the order of the basically inactive group,mildly active group,moderately active group,and severely active group (P<0.05).The levels of plasma ADAMTS13 in patients with LN were negatively correlated with the levels of IL-6,TNF-α,VWF and SLEDAI (r=-0.405,-0.464,-0.465,-0.925,P<0.05).【Conclusion】 The expression of ADAMTS13 in plasma is low in patients with LN,and the change of ADAMTS13 level is of great significance for the evaluation of disease activity in patients with LN. 2023 Vol. 40 (1): 88-91 [Abstract] ( 57 ) HTML (1 KB)  PDF (1135 KB)  ( 42 ) 92 Diagnostic Value of Uterine and Ovarian Artery Hemodynamics in luteinized Unruptured Follicle Syndrome CAO Yi-ran, YANG Xian-ting DOI: 10.3969/j.issn.1671-7171.2023.01.027 【Objective】 To investigate the diagnostic value of uterine and ovarian artery hemodynamics in luteinized unruptured follicle syndrome (LUFS). 【Methods】 A total of 67 LUFS patients who visited our hospital from January 2019 to April 2021 were selected, and 70 normal ovulating women who visited our hospital due to male infertility were selected as the control group. The maximum blood flow velocity (PSV) and resistance index (RI) of uterine and ovarian arteries were examined by color Doppler ultrasound, and their diagnostic value for LUFS was analyzed. 【Results】 PSV of functional ovarian artery in the LUFS group was significantly lower than that in the control group (P<0.05), while RI was significantly higher than that in the control group (P<0.05); The area under the ROC curve of the patients with LUFS diagnosed by PSV and RI in the functional ovarian artery during the periovulation period was 0.620 and 0.654 respectively, the cut-off values were 11.18 cm/s and 0.40 respectively, the sensitivity was 64.00% and 80.00% respectively, and the specificity was 60.00% and 62.00% respectively. 【Conclusion】 The PSV and RI of the functional ovarian artery in LUFS patients during the periovulatory period are different from those in normal controls, which has important clinical value in the diagnosis of LUFS. 2023 Vol. 40 (1): 92-94 [Abstract] ( 56 ) HTML (1 KB)  PDF (1189 KB)  ( 47 ) 95 Clinical Efficacy of PD-1 Monoclonal Antibody Combined with Microwave Ablation in the Treatment of Primary Liver Cancer HOU Long-hui, WEI Yang-chao DOI: 10.3969/j.issn.1671-7171.2023.01.028 【Objective】 To investigate the clinical efficacy of programmed death protein 1 (PD-1) monoclonal antibody combined with microwave ablation in the treatment of primary liver cancer. 【Methods】 The clinical data of 78 patients with primary liver cancer admitted to our hospital from January 2019 to October 2020 were analyzed retrospectively. According to the different treatment methods, they were divided into combined group (treated with PD-1 monoclonal antibody combined with microwave ablation) and control group (treated with single microwave ablation), with 39 patients in each group. The clinical efficacy, immune function and adverse reactions of the two groups were compared, and the survival rate was analyzed by Kaplan-Meier. 【Results】 The disease control rate and objective remission rate in the combined group were higher than those in the control group, and the difference was statistically significant (P<0.05). After treatment, the levels of CD39+ and CD73+ in both groups were lower than those before treatment, and those in the combined group were lower than those in the control group (P<0.05). The incidence of rash in the combined group was higher than that in the control group (P<0.05); There was no statistically significant difference in the occurrence of other adverse reactions between the two groups(P>0.05). The difference between the two groups was statistically significant (P<0.05). 【Conclusion】 PD-1 monoclonal antibody combined with microwave thermal ablation is helpful to improve the disease control rate and prolong the survival time of patients with primary liver cancer, and has certain safety. 2023 Vol. 40 (1): 95-97 [Abstract] ( 55 ) HTML (1 KB)  PDF (1178 KB)  ( 70 ) 98 Risk Factors of Hydrocephalus in Neonates with Purulent Meningitis GUO Hui-min, ZHANG Yan-xiang, JIA Yan,et al DOI: 10.3969/j.issn.1671-7171.2023.01.029 【Objective】 To investigate the risk factors of hydrocephalus in neonates with purulent meningitis. 【Methods】 The clinical data of 173 neonates with purulent meningitis admitted to our hospital from February 2019 to April 2021 were analyzed retrospectively. They were divided into hydrocephalus group (n=55) and non hydrocephalus group (n=118) according to whether hydrocephalus occurred. The demographic data, clinical data, laboratory test results and intracranial magnetic resonance examination results of the children were collected. Logistic regression analysis was used to analyze the risk factors affecting the occurrence of hydrocephalus, and the predictive value of hydrocephalus was evaluated by drawing a risk model ROC curve. 【Results】 Hydrocephalus occurred in 55 of 173 children with meningitis (31.79%). The clinical symptoms of children in hydrocephalus group were respiratory failure and convulsion, and the count of white blood cells in cerebrospinal fluid was>20×106/L, CSF glucose ＜2.2 mmol/L, CSF protein ＞ 1.5 g/L. The proportion of cerebrospinal fluid culture positive and imaging examination showed that leukomalacia, small white matter lesions, intraventricular hemorrhage, and purulent brain abscess were significantly higher than those of children without hydrocephalus (P<0.05). Logistic regression analysis showed that CSF glucose<2.2 mmol/L and CSF white blood cell count>20×106/L, CSF protein ＞1.5 g/L. Positive cerebrospinal fluid culture and intracranial magnetic resonance imaging showed small lesions in white matter, intraventricular hemorrhage, and purulent brain abscess were risk factors for hydrocephalus in children with purulent meningitis (P<0.05). The above risk factors were used to establish a prediction model by stepwise regression method. The ROC curve analysis showed that the area under the curve of the prediction model was 0.881, with high prediction value. 【Conclusion】 The risk model of neonatal purulent meningitis established by clinical symptoms, laboratory tests and intracranial MRI findings has a good predictive value for hydrocephalus. 2023 Vol. 40 (1): 98-101 [Abstract] ( 56 ) HTML (1 KB)  PDF (1212 KB)  ( 78 ) 102 Effect and Mechanism of Sarilumab on Proliferation and Apoptosis of Rheumatoid Arthritis Synoviocytes WANG Xiao, WANG Gui-ling, LIU Tong DOI: 10.3969/j.issn.1671-7171.2023.01.030 【Objective】 To investigate the effects of sarilumab on the proliferation and apoptosis of rheumatoid arthritis (RA) cells, and to analyze the related mechanisms. 【Methods】 Human RA cell line FLS cells (RA-FLS cells) were cultured in vitro and divided into the control group, the sarilumab low, medium and high dose groups (final concentration of 2.5 mg/L, 5.0 mg/L and 10.0 mg/L, respectively). The proliferation inhibition rate of RA-FLS cells was detected by CKK-8 and the apoptosis rate of RA-FLS cells was detected by Annexin V-FITC/PI double staining. The expression of anti-proliferation related nuclear Antigen (PCNA) , apoptosis protein B lymphocyte-2 (Bcl-2), Bcl-2 related X protein (Bax) and protein tyrosine kinase of Janus kinase 1/STAT3 pathway protein (JAK1, p-JAK1, STAT3 and p-STAT1) was detected by Western blotting. 【Results】 The proliferation inhibition rate, apoptosis rate and expression levels of PCNA and Bcl-2 protein in RA-FLS cells from the sarilumab low, middle and high dose groups were higher than those in the control group (P<0.05), while the levels of Bax and p-JAK1/JAK1, p-STAT3/STAT3 were significantly lower than those in the control group (P<0.05). All of those dectections were in dose dependent manner (P<0.05).【Conclusion】 Sarilumab may inhibit the proliferation of RA-FLS cells and induce apoptosis by inhibiting the activation of IL-6/JAK1/STAT3 pathway. 2023 Vol. 40 (1): 102-104 [Abstract] ( 61 ) HTML (1 KB)  PDF (1113 KB)  ( 80 ) 105 Comparison of Therapeutic Effects of Different Active Vitamin D3 Combined with Prednisone Acetate and Cyclophosphamide on Membranous Nephropathy ZHOU Shu-juan, HUANG Jing-jin DOI: 10.3969/j.issn.1671-7171.2023.01.031 【Objective】 To investigate the effect of different active vitamin D3 combined with prednisone acetate and cyclophosphamide on membranous nephropathy (MN),oxidative stress and markers of renal podocyte injury.【Methods】 A total of 124 MN patients were randomly divided into observation group and control group,62 patients in each group.The two groups were treated with conventional methods,cyclophosphamide and prednisone acetate.The control group was treated with alfacalciferol,and the observation group was treated with calcitriol.The therapeutic effects,markers of oxidative stress and renal podocyte injury before and after treatment,and drug safety during treatment were compared between the two groups. 【Results】 The urinary protein of the two groups after treatment was lower than that before treatment (P<0.05),and that of the observation group was lower than that of the control group (P<0.05).The total effective rate of the observation group was higher than that of the control group (P<0.05).The levels of advanced protein oxidation products (AOPP) and reactive oxygen species (ROS) in the two groups after treatment were lower than those before treatment (P<0.05),and those in the observation group were lower than those in the control group (P<0.05); After treatment,the level of superoxide dismutase (SOD) in both groups was higher than that before treatment (P<0.05),and that in the observation group was higher than that in the control group (P<0.05).The levels of urine podophyxin and Nephrin in the two groups after treatment were lower than those before treatment (P<0.05),and those in the observation group were lower than those in the control group (P<0.05).There was no significant difference in the incidence of total adverse reactions between the two groups (P>0.05).【Conclusion】 The combination of calcitriol, prednisone acetate and cyclophosphamide in the treatment of MN can enhance the curative effect,improve the oxidative stress and renal podocyte injury in patients with MN,and has good safety. 2023 Vol. 40 (1): 105-107 [Abstract] ( 53 ) HTML (1 KB)  PDF (1110 KB)  ( 55 ) 108 Effects of Fuzheng Huayu Capsule and Bifidotriple Viable Bacteria Assisted by Tenofovir on Liver Fibrosis in Elderly Patients with Hepatitis B Cirrhosis XU Juan, LI Xiao-xue DOI: 10.3969/j.issn.1671-7171.2023.01.032 【Objective】 To study the effect of Fuzheng Huayu Capsule and bifidobacterium triple viable bacteria combined with tenofovir on liver fibrosis and platelets in elderly patients with hepatitis B cirrhosis (HBC). 【Methods】 A total of 93 elderly HBC patients admitted to our hospital from April 2019 to April 2021 were selected as the research objects. Patients were divided into the Fuzheng Huayu group (31 cases), the viable bacteria group (31 cases) and The combined group (31 cases) by random number table method. The three groups were all given tenofovir. In addition, the Fuzheng Huayu group was given Fuzheng Huayu Capsules, the viable bacteria group was given bifidotriple viable bacteria, and the combination group was given Fuzheng Huayu Capsule + Bifidobacterium triple viable bacteria. The HBV DNA quantification (HBV-DNA), HBV-DNA negative convert rate, liver function indexes [alanine aminotransferase (ALT), total bilirubin (TBIL), aspartate aminotransferase (AST)], liver fibrosis indicators [type Ⅲ procollagen (PC-Ⅲ), hyaluronic acid (HA), laminin (LN), type Ⅳ collagen (Ⅳ-C)] and serum inflammatory factors [tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), interleukin-8 (IL-8)] were compared among the three groups. 【Results】 After treatment, the levels of HBV-DNA in the three groups were lower than those before treatment. The HBV-DNA level in the combination group was lower than that in the bifidotriple viable bacteria group and the Fuzheng Huayu group. While the Fuzheng Huayu group was lower than the live bacteria group. The difference were statistically significant (P<0.05).The negative rate of HBV-DNA in the combined group (93.55%) was higher than that in the viable bacteria group (70.97%) and the Fuzheng Huayu group (64.52%) (P<0.05). After treatment, the three groups of HBV-DNA, TBIL, AST, ALT , Ⅳ-C, PC-Ⅲ, LN, HA, IL-8, TNF-α, hs-CRP, IL-6 levels were lower than those before treatment; And the combined group was lower than the viable bacteria group and the Fuzheng Huayu group (P<0.05). 【Conclusion】 Fuzheng Huayu Capsules and bifidobacterium triple viable bacteria combined with tenofovir have significant effects in the treatment of elderly HBC, which can improve liver function, inhibit liver fibrosis, improve blood coagulation function, and inhibit inflammatory symptoms of the body. 2023 Vol. 40 (1): 108-111 [Abstract] ( 54 ) HTML (1 KB)  PDF (1136 KB)  ( 52 )

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