Abstract【Objective】 To investigate the changes and clinical value of plasma nitric oxide(NO),endothelin(ET),artial natriuretic polypeptide(ANP),renin activity(PRA) and angiotensin(AT) in patients with chronic renal failure(CRF) before and after dialysis.【Methods】 The patients with chronic renal failure and healthy people in our hospital were selected as the research subjects.There were 40 cases in the CRF group and 40 cases in the control group.The levels of plasma NO,ET,ANP,PRA and AT were measured before and after dialysis.Healthy volunteers in the control group received all measurements as well.The changes of indexes were compared between the CRF group and the control group; And they were also compared before and after dialysis in the CRF group.【Results】 The levels of plasma NO,ET,ANP,PRA and AT in the CRF group were significantly higher than those in the normal control group (P<0.05).Compared to before dialysis,plasma NO and ANP levels were significantly lower in the CRF group after dialysis (P<0.05),while levels of plasma PRA and AT were significantly higher (P<0.05).There was no significant difference in plasma ET level of the CRF group before and after dialysis (P>0.05).【Conclusion】 Hemodialysis treatment can lead to a decrease in plasma NO and ANP levels,an increase in PRA and AT levels,and a slight decrease in ET level,which indicate changes of plasma NO,ET,ANP,PRA,and AT levels in patients with chronic renal failure during hemodialysis.However,the impact of changes among those indicators is more complicated.In clinical application,it is necessary to refer to the specific diagnosis of each indicator.
SHEN Hong-liang,LUO Yong. Changes of Plasma NO,ET,ANP,PRA and AT in Patients with Chronic Renal Failure before and after Dialysis[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(1): 7-9.
[1] DEL V L,LOCATELLI F,CARINI M.What we know about oxidative stress in patients with chronic kidney disease on dialysis-clinical effects,potential treatment,and prevention[J].Semin Dial,2015,24(1):56-64. [2] 金秀平,王明新,魏剑芬.2型糖尿病慢性肾脏疾病患者血浆心钠素水平的变化及其临床意义[J].中国糖尿病杂志,2014,22(9):814-816. [3] 钟广芝,胡鹏飞.高通量血液透析对老年慢性肾衰竭患者血清中分子毒素清除效果研究[J].临床和实验医学杂志,2016,15(10):1007-1010. [4] VOUKALIS C,GYH L.Atrial fibrillation and end stage renal failure in patients receiving dialysis:balancing the risks and benefits of stroke prevention[J].Can J Cardiol,2017,33(6):705-707. [5] 周培一,白文英,武剑,等.慢性肾衰竭血液透析患者血浆中的LPA水平及与血脂及动脉粥样硬化的相关性[J].河北医学,2016,22(3):353-355. [6] VEMMEER M,KIEVIT W,KUPER H H,et al.Dialysis-dependent renal failure at diagnosis continues to be associated with very poor outcome in multiple myeloma-response to Murphy et al[J].Br J Haematol,2014,165(6):892-895. [7] 李开斌,谭微,唐雪莲,等.维持性血液透析对老年慢性肾衰竭合并心力衰竭患者心脏功能及血浆NT-proBNP的影响[J].河北医药,2017,39(17):2667-2669. [8] 刘宗旸,谢毅,陈彦,等.高低通量血液透析膜在维持性血液透析过程中的通透性、吸附性和生物相容性[J].中国组织工程研究,2015,19(38):6190-6194. [9] KARAGOZIAN R,RUTHERFORD A,CHRISTOPHER K B,et al.Spontaneous bacterial peritonitis is a risk factor for renal failure requiring dialysis in waitlisted liver transplant candidates.[J].Clin Transplant,2016,30(5):502-507. [10] 陈辉乐,徐昌隆,金领微,等.老年肾衰竭患者血液透析感染的危险因素分析[J].中华医院感染学杂志,2014,24(4):911-913. [11] MURPHY P T,BALDEO C,O'KELLY P,et al.Dialysis-dependent renal failure at diagnosis continues to be associated with very poor outcome in multiple myeloma.[J].Br J Haematol,2014,165(6):890-891. [12] 龚天美,周瑾,齐惠,等.慢性肾衰竭患者心肌标志物、感染标志物和凝血功能的变化及意义[J].标记免疫分析与临床,2017,24(8):862-866.
2023, Vol. 40 
