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| Clinical Efficacy of TURBT Combined with Chemotherapy in the Treatment of T2 Myometrial Invasive Bladder Cancer and the Influence on the Levels of Serum DKK and CIP2A |
| ZHOU Ke-bin, LIN Jia-wei, ZHAO Liu-cun |
| Department of Urology,Xi'an Ninth Hospital,Xi'an Shaanxi 710054 |
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Abstract 【Objective】 To investigate the clinical efficacy of transurethral resection of bladder tumor (TURBT) combined with chemotherapy in the treatment of T2 myometrial invasive bladder cancer and the influence on the levels of serum Dickkopf protein (DKK) and cancerous inhibitor of protein phosphatase 2A (CIP2A). 【Methods】 The clinical data of 130 patients with T2 myometrial invasive bladder cancer (MIBC) admitted to our hospital from January 2018 to January 2021 were retrospectively analyzed. According to the different treatment methods, they were divided into the observation group (treated with TURBT combined with chemotherapy, n=75) and the control group (treated with open radical cystectomy (ORC, n=55). The operation time, intraoperative blood loss, postoperative catheter indwelling time and surgical complications of the two groups were recorded, and the serum DKK and CIP2A levels of the two groups were compared before and after operation. 【Results】 The bleeding volume, operation time and indwelling catheter time in the observation group were significantly lower than those in the control group (P<0.05). After operation, the levels of serum CEA, CA19-9 and CA125 in the two groups were lower than those before operation, and the levels in the observation group were lower than those in the control group, the difference was statistically significant (P<0.05); The levels of serum DKK and CIP2A in the two groups were lower than those before operation, and those in the observation group were lower than those in the control group, with significant difference (P<0.05). The total incidence of complications in the observation group was lower than that in the control group, with a statistically significant difference (P<0.05). There was no significant difference in the recurrence rate between the observation group and the control group (P>0.05). 【Conclusion】 Compared with ORC operation, TURBT operation can significantly improve the clinical efficacy of bladder cancer patients, reduce the serum DKK and CIP2A levels, and have less trauma.
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Received: 15 June 2021
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2023, Vol. 40 
