Home  |  About Journal  |  Editorial Board  |  Instruction  |  Subscribe  |  Advertisement  |  Messages Board  |  Contact Us  |  中文

Forthcoming Articles    Current Issue    Archive    Advanced Search    Read Articles    Download Articles    Email Alert

Quick Search     Adv Search 2021 Vol. 38, No. 12 Published: 2021-12-26 Original Articles          Original Articles 1761 Diagnostic Value of Ultrasonography in Neonatal Pulmonary Sequestration ZHOU Meng-jie, ZHOU Yu, LIU Jin-qiao, et al DOI: 10.3969/j.issn.1671-7171.2021.12.001 【Objective】To investigate the value of ultrasonography in neonatal pulmonary sequestration. 【Methods】The clinical data of 22 children with PS diagnosed by postoperative pathology in Hunan children's Hospital from May 2019 to January 2021 were analyzed retrospectively. 【Results】Among the 22 children with PS, the lesions were unilateral, including 19 cases on the left and 3 cases on the right; the main ultrasonographic manifestations were solid masses in thoracic cavity or abdominal cavity in 20 cases and mixed cystic and solid masses in 2 cases, including 15 cases The blood supply was detected from the aorta (10 cases were from the thoracic aorta and 5 cases from the abdominal aorta); in the other 7 cases, the initial display of the blood supply artery of the mass was unclear in 3 cases, but the spectrum of the blood supply artery showed a high-speed and high resistance blood flow curve, suggesting that the blood supply artery came from the systemic circulation, and the display of the blood supply artery was unclear in 4 cases. There was no significant difference in the diagnostic rate of neonatal PS between ultrasound and enhanced CT(P>0.05). 【Conclusion】Ultrasonography can be used as an important auxiliary method for neonatal PS. 2021 Vol. 38 (12): 1761-1763 [Abstract] ( 84 ) HTML (1 KB)  PDF (1528 KB)  ( 71 ) 1764 Effects of Covid-19 Prevention and Control Measures in Different Periods on the Diagnosis and Prognosis of NSTEMI Inpatients Complicated with Pulmonary Infection WANG Qiang, YANG Cheng-jian, ZHANG Xiao-pu, et al DOI: 10.3969/j.issn.1671-7171.2021.12.002 【Objective】To analyze the diagnosis and prognosis of pulmonary infection in patients with non ST segment elevation myocardial infarction (NSTEMI) at different stages of New Coronavirus pneumonia (COVID-19). 【Methods】A retrospective analysis of 126 NSTEMI patients admitted to the Third Affiliated Hospital of Suzhou University under different prevention and control measures of COVID-19 was made into non COVID-19 epidemic group. (January 25, 2019 to February 25, 2019, non epidemic group, n=47), COVID-19 first responder group (January 25, 2020 to February 25, 2020, first responder group, n=42) and COVID-19 normal control group. (from January 25, 2021 to February 25, 2021, normal control group, n=37). The clinical characteristics, pulmonary infection and hospital mortality of the three groups were compared, and the influencing factors of NSTEMI inpatients complicated with pulmonary infection under epidemic prevention and control measures were analyzed. 【Results】 There were significant differences in visit time, bed time, heart rate and heart failure among the three groups (P<0.05). There was significant difference in the incidence of pulmonary infection among non epidemic group, primary response group and normal prevention and control group (P<0.001). Multivariate binary logistic regression analysis showed that visit time, heart failure and bed time were the influencing factors of pulmonary infection in NSTEMI patients (mean P<0.05). 【Conclusion】 The treatment measures during the first-class response of covid-19 prevention and control improved the detection rate of pulmonary infection in patients with NSTEMI, and did not increase the adverse prognosis in hospital in patients with NSTEMI complicated with pulmonary infection. 2021 Vol. 38 (12): 1764-1766 [Abstract] ( 68 ) HTML (1 KB)  PDF (1124 KB)  ( 110 ) 1767 Analysis of Short-term Effects on Preoperative Neoadjuvant Chemotherapy for Total Mesentery Excision in Patients with Middle and Low Rectal Cancer SONG Zhong-xue, ZHENG Shao-hua DOI: 10.3969/j.issn.1671-7171.2021.12.003 【Objective】To observe the short-term effect of preoperative neoadjuvant chemotherapy in improving total mesentery excision for patients with mid-low rectal cancer. 【Methods】A total of 153 patients with mid-low rectal cancer treated in our hospital were retrospectively analyzed. 96 patients underwent open total mesorectal excision (control group), 57 patients underwent neoadjuvant chemotherapy (observation group) before surgery, and then underwent open total mesorectal excision. The perioperative situation, surgical treatment effect, serological indexes and survival conditions of the two groups were compared. 【Results】There was no significant difference between the two groups in operation time, intraoperative blood loss, postoperative first exhaust time, postoperative first defecation time, feeding fluid time, postoperative hospital stay and postoperative complication rate (P>0.05). The anus-preserving rate in the observation group was significantly higher than that in the control group (P<0.05).Before treatment, there was no significant difference in serum CEA, CA19-9 and CA125 between the two groups. After operation, the level of each index decreased significantly (P<0.05), and the improvement in the observation group was more obviously(P<0.05).There was no significant difference in CD3+, CD4+ and CD4+/CD8+ between the two groups before treatment. The levels of various indexes after operation were significantly increased (P<0.05), and the improvement in the observation group was more obvious (P<0.05).There was no significant difference between the two groups in the length of proximal end, distal end, distant metastasis and mean survival time (P<0.05), The number of lymph nodes detected in the observation group was significantly lower than that in the control group (P<0.05). 【Conclusion】 Preoperative neoadjuvant chemotherapy can significantly improve anus-preserving rate, reduce the value of CEA, CA19-9 and CA125, and improve the body's immune function. It has definite curative effect and is worthy of clinical application. 2021 Vol. 38 (12): 1767-1770 [Abstract] ( 65 ) HTML (1 KB)  PDF (1146 KB)  ( 55 ) 1771 Efficacy of Recombinant Human Endostatin Combined with NP Regimen in Treatment of Recurrent and Metastatic Nasopharyngeal Carcinoma CHEN Qi, CHEN Xuan, YOU Lan, et al DOI: 10.3969/j.issn.1671-7171.2021.12.004 【Objective】To explore the clinical efficacy of recombinant human endostatin (ES) combined with NP regimen (vinorelbine+cisplatin) in the treatment of recurrent and metastatic nasopharyngeal carcinoma. 【Methods】A total of 82 patients with recurrent and metastatic nasopharyngeal carcinoma admitted to Shanghai Shuguang Hospital were selected as the research objects. According to the treatment plan, they were divided into the observation group and the control group. There were 40 patients in the control group who were treated with a single NP regimen, while 42 patients in the observation group were treated with NP regimen combined with ES. Both groups of patients were evaluated for efficacy and adverse drug reactions after 4 cycles of treatment. The 1-year survival rate of the two groups of patients was followed-up and recorded. 【Results】The disease control rate of the observation group was 90.47%, which was higher than that of the chemotherapy group (70.00%) (P<0.05). Most patients in the two groups had mild adverse reactions of grade I to II. There was no significant difference in the incidence of various adverse reactions in the two groups (P>0.05). In the control group, 21 patients died and the 1-year survival rate was 47.50% with the survival period of 4 to 8 months. While 13 patients died in the observation group showing he 1-year survival rate was 69.05%with the survival period was 7 to 11 months. There was a statistically significant difference in survival curves between the observation group and the control group (P<0.05). 【Conclusion】ES combined with NP regimen for patients with recurrent and metastatic advanced nasopharyngeal carcinoma can effectively improve the patient's disease control rate, prolong the patient's life cycle and have good safety. 2021 Vol. 38 (12): 1771-1773 [Abstract] ( 53 ) HTML (1 KB)  PDF (1198 KB)  ( 38 ) 1774 Application of Compound Polyethylene Glycol Electrolyte Powder in Preoperative Preparation of Patients Undergoing Colonic Esophagectomy YUAN Shao-feng, HU Xian-zhen DOI: 10.3969/j.issn.1671-7171.2021.12.005 【Objective】 To investigate the clinical effect of compound polyethanol electrolyte powder on intestinal preparation before colon esophageal replacement. 【Methods】 A total of 106 patients with colon replacement esophagus was randomly divided into observation group and control group, with 53 cases in each group. The control group was given magnesium sulfate orally for intestinal preparation, and the observation group was given compound polyethylene glycol electrolyte powder for intestinal preparation. The intestinal cleanliness, adverse reactions, complications and patient satisfaction were compared between the two groups.【Results】The cleanliness scores of left colon, transverse colon, right colon and whole intestinal cavity in the observation group were significantly higher than those in the control group (P<0.05). The total incidence of abdominal distension and other adverse reactions in the observation group was 18.87% (10/53), which was significantly lower than 43.40% (23/53) in the control group (P<0.05); The total incidence of incision infection and other complications in the observation group was 11.32% (6/53), which was significantly lower than 28.30% (15/53) in the control group (P<0.05). The satisfaction of patients in the observation group was 96.23% (51/53), which was significantly higher than 84.91% (45/53) in the control group (P<0.05). 【Conclusion】 Compound polyethanol electrolyte powder for intestinal preparation is helpful to improve intestinal cleanliness, reduce the incidence of complications and adverse reactions, and enhance patient satisfaction. 2021 Vol. 38 (12): 1774-1776 [Abstract] ( 61 ) HTML (1 KB)  PDF (1124 KB)  ( 49 ) 1777 Relationship between Bone Metabolism Indexes and Glomerular Filtration Rate in Elderly Patients with Type 2 Diabetic Nephropathy CHEN Yu-chang, WANG Chong-yang DOI: 10.3969/j.issn.1671-7171.2021.12.006 【Objective】To investigate the correlation between bone metabolism indexes and estimated glomerular filtration rate (eGFR) in elderly patients with type 2 diabetic nephropathy. 【Methods】A total of 129 elderly patients with type 2 diabetic nephropathy admitted from May 2019 to October 2020 were selected as the observation group, and 125 patients with simple type 2 diabetes (T2DM) were selected as the control group. The general information, bone metabolism indexes and eGFR of the two groups of patients were recorded. Bone metabolism index ｛blood calcium (Ca), blood phosphorus (P), osteocalcin (OCN), 25 hydroxy vitamin D3[25(OH)D3], parathyroid hormone (PTH) and total type Ⅰ｝ procollagen amino terminal were compared between the two groups. The correlation of eGFR with bone metabolism index, parathyroid hormone (PTH) and propeptide (T-PINP) was analyzed. 【Results】There were no statistically significant differences in gender, age, body mass index (BMI), combined with hypertension, and combined with hyperlipidemia between the two groups (P>0.05). Compared with the control group, the observation group had a longer course of diabetes with higher level of fasting blood glucose (FPG), 2 h postprandial blood glucose (2hPG), urine albumin, blood P, OCN, PTH, T-PINP and eGFR increased (P<0.05), while the blood Ca and 25(OH)D3 levels decreased in the observation group (all P<0.05). Compared to patients with renal function stage Ⅰ~Ⅱ, OCN, PTH and T-PINP in patients with stage Ⅲ~Ⅴ increased (all P<0.001), while their 25(OH)D3 and eGFR decreased (all P<0.05). OCN (r=-0.863, P=0.002), PTH (r=-0.754, P=0.013) and T-PINP (r= -0.728, P=0.018) were negatively correlated with eGFR(r=-0.863,P=0.002;r=-0.754,P=0.013;r=-0.728,P=0.018), while 25(OH)D3 was positively correlated with eGFR (r=0.802, P=0.005). 【Conclusion】There are abnormalities in bone metabolism and eGFR in elderly patients with type 2 diabetic nephropathy, and there is a correlation of eGFR with OCN, PTH, T-PINP and 25(OH)D3. 2021 Vol. 38 (12): 1777-1779 [Abstract] ( 58 ) HTML (1 KB)  PDF (1125 KB)  ( 43 ) 1780 Relationship between Histone Deacetylase 6 Protein Level in Tissue Samples and Clinicopathological Features of Patients with Endometrial Cancer SONG Yan, MA Cheng-bin, LI Bing, et al DOI: 10.3969/j.issn.1671-7171.2021.12.007 【Objective】To investigate the relationship between histone deacetylase 6 (HDAC6) protein level in tissue samples and clinicopathological features of patients with endometrial cancer. 【Methods】 A total of 90 patients with endometrial cancer who underwent surgery in our hospital from March 2018 to March 2020 was selected as the research objects. The specimens of cancer tissues and adjacent normal tissues of all patients after surgery were taken, and the expression of HDAC6 protein in tissue samples was measured by immunohistochemical staining. The positive rate of HDAC6 protein in cancer tissues and adjacent normal tissues of all patients and the expression of HDAC6 protein in cancer tissues of endometrial cancer patients with different clinicopathological features were compared. 【Results】The positive rate of HDAC6 protein in endometrial carcinoma was significantly higher than that in adjacent tissues (P<0.05). There was no significant difference in the positive rate of HDAC6 protein in endometrial cancer patients with different age, pathological classification, histological grade and cervical involvement (P>0.05); The positive rate of HDAC6 protein in patients with stage Ⅲ~Ⅳ was significantly higher than that in patients with stageⅠ~Ⅱ(P<0.05); The positive rate of HDAC6 protein in patients with lymph node metastasis was significantly higher than that in patients without lymph node metastasis (P<0.05); The positive rate of HDAC6 protein in patients with myometrial infiltration ≥ 1/2 was significantly higher than that in patients with myometrial infiltration < 1/2 (P<0.05). 【Conclusion】 The expression of HDAC6 protein is up-regulated in endometrial carcinoma, and its expression level is closely related to FIGO stage, lymph node metastasis and myometrial invasion depth. 2021 Vol. 38 (12): 1780-1783 [Abstract] ( 50 ) HTML (1 KB)  PDF (1687 KB)  ( 54 ) 1784 Effects of Salkubatrol Valsartan on Cardiac Function and Inflammatory Factors in Patients with Heart Failure Caused by Decreased Ejection Fraction LIU Tong, YAN Yang-jin, SHI Jing-yi, et al DOI: 10.3969/j.issn.1671-7171.2021.12.008 【Objective】To investigate the effect of salkubatrol valsartan (S/V) on heart failure with reduced ejection fraction. 【Methods】A total of 104 patients with HFREF was randomly divided into observation group and control group, with 52 cases in each group. The control group was given routine anti heart failure treatment, and the observation group was given S/V treatment on the basis of the control group. The adverse reactions, clinical efficacy after 3 months of treatment and before and after treatment and the levels of cardiac function parameters in the two groups were compared between the two groups included left atrial diameter (LA), left ventricular end diastolic diameter (LVEDD), left ventricular ejection fraction (LVEF), blood flow mediated vasodilation (FMD), inflammatory factors [interleukin-6 (IL-6), interleukin-33 (IL-33), and tumor necrosis factor-α(TNF-α)and intercellular adhesion factor-1 (ICAM-1)], and the rehospitalization rates of the two groups were recorded.【Results】The total effective rate in the observation group was 96.15%, higher than 75.00% in the control group, The difference was statistically significant (P<0.05). After treatment, LVEF and FMD in the two groups were higher than those before treatment, LVEDD and LA were lower than those before treatment, and the levels of serum IL-6, IL-33 and ICAM-1 in the observation group were lower than those before treatment (P<0.05) . There was no significant difference between the two groups in the total incidence of adverse reactions during treatment and rehospitalization rate within half a year of follow-up (P>0.05). 【Conclusion】The addition of S/V to HFREF on the basis of routine treatment can significantly improve the clinical efficacy, improve the cardiac function of patients, and reduce inflammatory reaction. It has good safety and is worthy of clinical promotion. 2021 Vol. 38 (12): 1784-1786 [Abstract] ( 51 ) HTML (1 KB)  PDF (1119 KB)  ( 48 ) 1787 Effect of Drug-eluting Beads Transcatheter Arterial Chemoembolization and Surgical Resection on Short-term and Long-term Efficacy of Stage Ⅱb Primary Liver Cancer WANG Song, WANG Wen-chao, YANG Jun-chi, et al DOI: 10.3969/j.issn.1671-7171.2021.12.009 【Objective】To compare the near-and long-term efficacy of drug-loaded microspheres through transcatheter hepatic arterial embolization (TACE) and surgical resection for stage Ⅱb primary liver cancer. 【Methods】A total of 68 patients with primary liver cancer of stage Ⅱb were random divided into groups A and B, with 34 cases each. The group B underwent surgical resection, while group A received CalliSpheres drug-eluting beads transarterial chemoembolization (DEB-TACE). Both groups received transarterial chemoembolization after relapse. The progression-free survival (DFS), overall survival (OS), blood biochemical data before and after treatment, complications, and short-term efficacy were compared between the two groups. 【Results】There were no significant differences in objective remission rate and the disease control rate at 1 month and at 3 months after treatment between the two groups (P>0.05). Compared with before treatment, the levels of VEGF, bFGF, AFP, TBIL, AST and ALT in both groups decreased after 3 months and after 6 months of treatment(P<0.05), while ALB increased after 3 months of treatment(P<0.05). There was no significant difference in the average cumulative number of TACE treatments between the two groups within 2 years after treatment (P>0.05). There was no significant difference in the incidence of complications between the two groups (P>0.05). There were no significant differences in cumulative DFS rate and cumulative OS rate between group A and group B (P>0.05). 【Conclusion】DEB-TACE is effective in the treatment of stage Ⅱb primary liver cancer, which is equivalent to the effect and prognosis of surgical resection, while DEB-TACE can reduce the number of TACE treatments and reduce the cost of hospitalization. 2021 Vol. 38 (12): 1787-1790 [Abstract] ( 63 ) HTML (1 KB)  PDF (1771 KB)  ( 69 ) 1791 Impact of Shortened Dental Arch on Oral Health-related Quality of Life over a Period of 10 Years WANG Xin-rong, JIN Hong DOI: 10.3969/j.issn.1671-7171.2021.12.010 【Objective】To compare oral health-related quality of life (OHRQoL) in patients with either molar replacement by partial removable dental prostheses (PRDP) or with restored shortened dental arches (SDA) over a period of 10 years. 【Methods】A total of 151 patients with bilateral molar loss in Department of Prosthodontics from March 2008 to March 2010 were enrolled, and they were divided into two groups by different treatment methods, the RPD group (n=77) and SDA group (n=74). OHRQoL of patients were assessed by Oral Health Impact Profile-14 (OHIP-14). The OHIP-14 score before treatment, 1~2 months, 6 months, 1 year, 2 years, 3 years, 4 years, 5 years, 6 years, 7 years, 8 years, 9 years, and 10 years after treatment were recorded. And the repair effects in patients with different characteristics after treatment and OHIP-14 scores were recorded. Multiple linear regression analysis was used to analyze the influencing factors of OHRQoL after treatment with SDA. 【Results】After treatment, the OHIP-14 scores in both groups were lower than before treatment (P<0.05). However, the OHIP-14 scores at different time points after treatment had no significant difference between the two groups (P>0.05). After treatment, the OHIP-14 scores of patients with different ages and education levels were significantly different (P<0.05). The incidence of gingival bleeding and prosthetic detachment in the SDA group was significantly lower than that in the RPD group. The satisfaction degree of restoration in the SDA group was significantly higher than that of RPD group (P<0.05). Multiple linear regression analysis showed that age and education level were independent risk factors for OHRQoL after treatment (P<0.05). The OHRQoL of both groups showed no significant difference in terms of treatment method and treatment time. (P>0.05). 【Conclusion】Both RPD and SDA treatment can significantly improve OHRQoL in patients with molar loss. During 10 years of follow-up, the influence of the two treatment options on OHRQoL has no significant difference and remains stable, however, SDA has a lower incidence of gingival bleeding and prosthetics-shedding, and higher satisfaction degree. So clinical treatment should be applied based on actual situation of patients. 2021 Vol. 38 (12): 1791-1794 [Abstract] ( 47 ) HTML (1 KB)  PDF (1142 KB)  ( 75 ) 1795 Clinical Value of GD-EOB-DTPA Contrast-enhanced Imaging and DWI in the Diagnosis of Small Hepatocellular Carcinoma ZENG Fei-xiang, MAO Si-xin, WU Wei-jun DOI: 10.3969/j.issn.1671-7171.2021.12.011 【Objective】Objective to investigate the value of contrast-enhanced and diffusion-weighted imaging (DWI) with liver cell specific contrast agent (GD-EOB-DTPA) in the diagnosis of small hepatocellular carcinoma (sHCC). 【Methods】The clinical data of 83 patients with suspected HCC diagnosed by ultrasound or CT from November 2016 to December 2020 were selected, All patients were diagnosed by GD-EOB-DTPA contrast-enhanced (hepatobiliary phase, portal phase and arterial phase) combined with DWI on the basis of conventional imaging. Taking the pathological results as the gold standard, the positive detection rates of sHCC by different imaging methods were compared according to the working characteristic curve (ROC) of the test results, and the accuracy was determined according to the area under the curve (AUC).【Results】 Fifty three of 83 patients were diagnosed as positive sHCC by pathological examination; The diagnostic results of GD-EOB-DTPA showed that there were 33 patients with positive sHCC and 20 patients with negative sHCC; The results of DWI showed that there were 34 patients with positive SHCC and 22 patients with negative SHCC; The diagnostic results of GD-EOB -DTPA combined with DWI showed that there were 45 patients with positive sHCC and 27 patients with negative sHCC (P<0.05); The positive detection rates of GD-EOB-DTPA and DWI were lower than those of GD-EOB-DTPA combined with DWI (P>0.05); the diagnostic AUC of GD- EOB-DTPA combined with DWI was 0.875, which was higher than that of GD-EOB-DTPA or DWI alone. 【Conclusion】 The combination of GD-EOB-DTPA contrast enhancement and DWI can effectively improve the positive detection rate of SHCC. 2021 Vol. 38 (12): 1795-1797 [Abstract] ( 56 ) HTML (1 KB)  PDF (1121 KB)  ( 38 ) 1798 Clinical Comparative Study of Two Methods (Arthroscopy and Nonoperation) in Treatment of Posterior Cruciate Ligament Inferior Insertion Avulsion Fracture JIANG Zu-kang, ZHOU Hong-xing DOI: 10.3969/j.issn.1671-7171.2021.12.012 【Objective】To explore the clinical comparative study of the treatment of posterior cruciate ligament (PCL) inferior insertion avulsion fracture by arthroscopic suture fixation and nonoperation. 【Methods】The clinical data of 62 (Meyers Classification:Ⅱ、Ⅲ) patients with posterior crucial ligament inferior insertion avulsion fracture in our department from September 2013 to May 2018 were included in the retrospective study. They were divided into two groups randomly. The observation group included 32 patients (20 male cases and12 female cases) with PCL inferior insertion avulsion fracture treated with suture fixation by arthroscopy, while the control group contained 30 patients (17 male cases and 13 female cases). The healing time, tibial displacement (posterior drawer test: PDT), the Lysholm knee score, the hospital special surgery knee score (HSS) of both groups were compared between the two groups. 【Results】Both groups of patients were followed up for 6-24 months with average of (15.7±1.26) months. Results showed that 3 cases of non-healing by surgery in the control group nonunion who needed reoperation. The healing time of the observation group was significantly shorter than that of the control group (P<0.05), PDT grade, Lysholm score and HSS in the observation group were superior to the control group. 【Conclusion】The arthroscopic suture fixation of PCL inferior insertion avulsion fracture (Meyers Classification:Ⅱ、Ⅲ) is more effective than nonoperative treatment, which has higher stability and more improves joint motion function. 2021 Vol. 38 (12): 1798-1801 [Abstract] ( 50 ) HTML (1 KB)  PDF (1140 KB)  ( 99 ) 1802 Effect of Halliwick Therapy on Lower Limb Motor Skills in Children with Spastic Cerebral Palsy ZHANG Juan, WANG Yi-mei, XIONG Ying, et al DOI: 10.3969/j.issn.1671-7171.2021.12.013 【Objective】To investigate the effect of halliwick therapy on lower limb motor skills in children with spastic cerebral palsy. 【Methods】A total of 80 children with spastic cerebral palsy treated in our hospital from January 2018 to December 2019 were collected and divided into control group and observation group according to the wishes of their families, with 40 cases in each group. The control group received routine rehabilitation training, and the observation group received halliwick therapy on the basis of the control group. After 3 months of rehabilitation training, the lower limb balance ability, gross motor ability and fine motor ability of the two groups were compared. 【Results】 After 3 months of treatment, The balance ability and gross motor ability of lower limbs in the control group were not significantly improved (P>0.05), and the fine motor ability was enhanced (P<0.05); the balance ability, fine motor ability and gross motor ability of lower limbs in the observation group were significantly enhanced (P<0.05), and the fine motor ability was significantly stronger than that in the control group (P<0.05). 【Conclusion】 Halliwick therapy can effectively improve children's lower limb motor skills, improve children's overall coordination, especially improve children's gross motor ability of lower limbs, which is worthy of further clinical application. 2021 Vol. 38 (12): 1802-1805 [Abstract] ( 71 ) HTML (1 KB)  PDF (1139 KB)  ( 103 ) 1806 Comparison of Total Gastrectomy and Subtotal Gastrectomy in the Treatment of Locally Advanced Siewert Ⅱ and Ⅲ AEG FENG Hai-bo, LU Xi-wei DOI: 10.3969/j.issn.1671-7171.2021.12.014 【Objective】To compare total gastrectomy and Proximal gastrectomy for locally advanced Siewert Ⅱ and Ⅲ adenocarcinoma of esophagogastric junction (AEG) . 【Methods】 A total of 122 patients with locally advanced Siewert Ⅱ and Ⅲ AEG treated in Shaanxi Cancer Hospital from October 2015 to October 2018 were randomly divided into control group and observation group, with 61 cases in each group. The control group was treated with proximal subtotal gastrectomy, the observation group was treated with total gastrectomy, and the patients were followed up for 36 months The operation and postoperative recovery of the two groups were compared, the preoperative and postoperative quality of life scores of the two groups were recorded, and the incidence of postoperative complications and 36 month overall survival rate were counted. 【Results】The operation time, the number of lymph nodes and the number of positive lymph nodes in the observation group were higher than those in the control group; The first exhaust time, recovery time of bowel sounds and first eating time in the postoperative group were shorter than those in the control group, The scores of the special scale for esophageal and gastric junction cancer (QLQ-OG25) 12 months after operation in the two groups were lower than those before operation, and the observation group was significantly lower than that in the control group (P<0.05).The 36 month overall survival rate of the observation group was 65.52%, which had no significant difference compared with 69.49% of the control group (P>0.05). 【Conclusion】 Total gastrectomy and proximal subtotal gastrectomy can achieve similar survival rates in the treatment of locally advanced Siewert Ⅱ and Ⅲ AEG, but total gastrectomy has better lymph node dissection effect, higher quality of life and good safety, which is conducive to postoperative recovery. 2021 Vol. 38 (12): 1806-1809 [Abstract] ( 76 ) HTML (1 KB)  PDF (1223 KB)  ( 58 ) 1810 Bioinformatics Analysis of NCAPG Gene on Prognosis of Colorectal Cancer DONG Yun-peng, LIU Hong-tao, ZHANG Cheng DOI: 10.3969/j.issn.1671-7171.2021.12.015 【Objective】To investigate the expression and clinical significance of non chromosomal structure maintenance subunit (SMC) agglutinin ⅰ complex subunit G(NCAPG) gene in colorectal cancer. 【Methods】Oncomine database, GEPIA database and UALCAN database were used to analyze the difference of NCAPG expression in colorectal cancer and normal tissues, and the relationship between NCAPG expression and clinical indicators was analyzed as well. GEPIA and GSCA databases were used to analyze the relationship between the expression level of NCAPG and the prognosis of colorectal cancer patients. TIMER database was used to analyze the correlation between NCAPG and immune infiltrating cells. GSCA database was used to analyze the activity of NCAPG in tumor pathways.【Results】The expression of NCAPG gene was up-regulated in colorectal cancer tissues, and the expression level of NCAPG was correlated with the clinical stage and lymph node stage of the tumor. Patients with increased expression of NCAPG had better overall survival (OS) and progression-free survival (PFS). NCAPG can promote the expression of CD8+T cells. NCAPG was associated with apoptosis, cell division, epithelial-mesenchymal transformation (EMT) and estrogen receptor (ER) in colorectal cancer, which had CCNB1 gene as co-expressed gene.【Conclusion】The expression of NCAPG gene is increased in colorectal cancer, and the high expression of NCAPG gene can lead to a better prognosis, which can be used as a prognostic biomarker in colorectal cancer. Further experimental and clinical trials are essential to further clarify the value of NCAPG gene in colorectal cancer. 2021 Vol. 38 (12): 1810-1814 [Abstract] ( 80 ) HTML (1 KB)  PDF (3458 KB)  ( 144 ) 1815 Dynamic Changes of CRP/HGB, ESR and Gal-3 in Patients with Acute Infective Endocarditis during Treatment WANG Ying, YANG Kun, HE Yong DOI: 10.3969/j.issn.1671-7171.2021.12.016 【Objective】To investigate the dynamic changes of C-reactive protein (CRP) to hemoglobin (Hgb) ratio (CRP/Hgb), erythrocyte sedimentation rate (ESR) and galactose lectin-3 (Gal-3) in patients with acute infective endocarditis (AIE).【Methods】A total of 147 patients with AIE was selected. According to the survival within 1 month after admission, they were divided into death group (n=23) and survival group (n=124). The levels of CRP/HGB, ESR, Gal-3, white blood cell count (WBC) and procalcitonin (PCT) were compared between the two groups before treatment, 1 week after treatment and 2 weeks after treatment. The relevant influencing factors of prognosis were analyzed by logistic regression equation, and the working characteristic curve of subjects was used (ROC) the prognostic value of each index was analyzed. 【Results】 After 1 and 2 weeks of treatment, the levels of serum CRP/HGB, ESR, Gal-3, WBC and PCT in the death group were not significantly different from those before treatment (P>0.05); the above indexes in the survival group were lower than those before treatment, and the death group was higher than that in the survival group (P<0.05). Logistic regression equation analysis showed that the levels of CRP/HGB, ESR and Gal-3 after 1 and 2 weeks of treatment were related factors affecting the prognosis of patients (P<0.05). The AUCs of CRP/HGB, ESR and Gal-3 after 2 weeks of treatment were 0.827, 0.844 and 0.836 respectively (P<0.05), and the AUC of CRP/HGB+ESR+Gal-3 was 0.949 (P<0.05). 【Conclusion】 Monitoring the levels of CRP/HGB, ESR and Gal-3 during treatment is of great significance to evaluate the prognosis of AIE patients, and can assist in predicting the prognosis of AIE patients. 2021 Vol. 38 (12): 1815-1817 [Abstract] ( 40 ) HTML (1 KB)  PDF (1330 KB)  ( 30 ) 1818 Predictive Value of Preoperative Platelet Count for Skin Graft Survival after Meek Skin Grafting in Severe Burn Patients LI Xiao-jing, ZHANG Shen-lu, MA Ya-jun DOI: 10.3969/j.issn.1671-7171.2021.12.017 【Objective】To explore the predictive value of preoperative platelet count for skin graft survival after Meek skin grafting in severe burn patients. 【Methods】A total of 80 patients with severe burns who underwent Meek skin grafting were enrolled in this study. Patients were divided into two groups according to the survival of skin grafts 14 days after surgery. There were 57 patients in the skin survival good group (skin graft survival rate ≥70%) and 23 patients in the skin survival poor group (skin graft survival rate < 70%). General condition, third-degree burn area, burn index, combined inhalation injury, preoperative cystatin C, albumin, neutrophil, hemoglobin, C-reactive protein, procalcitonin, systolic blood pressure, diastolic blood pressure, and platelet count were collected. Multiple Logistic regression analysis was used to analyze the risk factors of skin graft survival. ROC curve was used to analyze the diagnostic efficacy of preoperative platelet count in patients with skin graft survival. 【Results】Compared to the group with good skin graft survival, the third-degree burn area and burn index in the skin graft poor survival group were higher, while the preoperative platelet count was lower (P<0.05) . Multivariate Logistic regression analysis showed that low platelet count was an independent risk factor for poor skin graft survival in Meek patients after skin grafting (OR=5.010,P<0.05). The AUC and truncation value for preoperative platelet count to predict the survival rate of grafting skins were 0.826 (95%CI:0.793~0.867) and 126.78 ×1012/L,respectively. The sensitivity was 85.33% and specificity was 70.62%. 【Conclusion】Preoperative platelet count is an independent risk factor for skin graft survival after Meek skin grafting in severe burn patients. It has a certain predictive value for skin graft survival after Meek skin grafting and can be used to predict the survival of the skin graft and determine the optimal operation time. 2021 Vol. 38 (12): 1818-1821 [Abstract] ( 62 ) HTML (1 KB)  PDF (1170 KB)  ( 85 ) 1822 Effect of Preoperative Low Intensity Slow Motion Training on Quadriceps Femoris Muscle Strength in Patients with Knee Osteoarthritis after Total Knee Arthroplasty FU Xiao-wei, SHAO Zheng-hai, XU Cai-xia, et al DOI: 10.3969/j.issn.1671-7171.2021.12.018 【Objective】To investigate the effect of preoperative low-intensity slow motion training (LST) on quadriceps femoris weakness in patients with knee osteoarthritis after total knee arthroplasty (TKA). 【Methods】 A toal of 86 patients with knee osteoarthritis to be treated with TKA in Shanghai Changhang hospital and Shanghai Kaiyuan Orthopedic Hospital from January 2015 to December 2020 was selected as the research object. The patients were randomly divided into control group and LST group, with 43 cases in each group. The control group was given drug treatment, and the LST group was given LST training on the basis of the control group. The quadriceps femoris strength (QST), pain degree (VAS), knee circumference [knee circumference 1cm above patella (1 cm KC) and 10cm above patella (10 cm KC)] and thigh volume (TV) were measured at 4 weeks before operation, 1 day before operation and after operation, and the levels of serum superoxide dismutase (SOD), malondialdehyde (MDA), tumor necrosis factor α(TNF-α) and interleukin -1β(IL-1β) were observed. 【Results】 The QST and SOD of the two groups was significantly lower than that at 4 weeks and 1 day before operation (P<0.05), and the above indexes in the LST group were lower than those in the control group (P<0.05). After operation, 1 cm KC, 10 cm KC, TV, TNF-α, IL-1β and MDA, in the two groups were significantly higher than those at 4 weeks and 1 day before operation (P<0.05), and the above indexes in the LST group were lower than those in the control group (P<0.05). VAS during QST, VAS, during stand up and walk time test, stand up and walk time test in the two groups were significantly higher than those at 4 weeks and 1 day before operation (P<0.05), and the above indexes in the LST group were lower than those in the control group (P<0.05). 【Conclusion】 LST can improve the strength of quadriceps femoris, reduce the swelling of knee and thigh and reduce the degree of pain in patients with TKA. 2021 Vol. 38 (12): 1822-1825 [Abstract] ( 59 ) HTML (1 KB)  PDF (1149 KB)  ( 92 ) 1826 Effect Analysis of Gemcitabine Combined with Oxaliplatin in the Treatment of Relapsed or Refractory NHL Aziguli, MAO Min, Muhebaier·Abuduer, et al DOI: 10.3969/j.issn.1671-7171.2021.12.019 【Objective】To investigate the effect of gemcitabine combined with oxaliplatin in the treatment of recurrent refractory non-hodgkin's lymphoma (NHL). 【Methods】The clinical data of 86 patients with relapsed refractory NHL in our hospital from July 2015 to July 2018 were retrospectively analyzed. According to the treatment methods, the control group (43 cases) was treated with vinorelbine combined with oxaliplatin, while the observation group (43 cases) was treated with gemcitabine combined with oxaliplatin. The therapeutic effects of the two groups were compared. 【Results】The clinical effective rate of the observation group was 72.09% (31/43), which was higher than that of the control group (62.79%, 27/43). However, the difference was not statistically significant (χ2= 0.847, P=0.357).After treatment, the KPS scores of the two groups were both higher than corresponding KPS scores before treatment (P<0.05), while the difference of post-treatment between the control group and the observation group was not statistically significant (P>0.05).The incidence of thrombocytopenia, gastrointestinal reactions and peripheral nerve symptoms in the observation group was lower than that in the control group (P<0.05).After 12 months of follow-up, the progression-free survival rate and overall survival rate were 58.14% and 81.40% in the study group,respectively. If they were compared to the progression-free survival rate (55.81%) and overall survival rate (76.74%) in the control group, the difference was not statistically significant (χ2=0.047, P=0.827; χ2=0.281, P=0.596). 【Conclusion】Combined use of gemcitabine and oxaliplatin in the treatment of relapsed and refractory NHL has the same effect as vinorelbine combined with oxaliplatin. 2021 Vol. 38 (12): 1826-1828 [Abstract] ( 89 ) HTML (1 KB)  PDF (1118 KB)  ( 28 ) 1829 Analysis of Risk Factors for Acute Cerebrovascular Events after Catheter Radiofrequency Ablation in Elderly Patients with Atrial Fibrillation XU Li-qing, CHE Yuan-hang DOI: 10.3969/j.issn.1671-7171.2021.12.020 【Objective】To investigate the risk factors of acute cerebrovascular events after catheter radiofrequency ablation (RFCA) in elderly patients with atrial fibrillation (AF). 【Methods】The general data of 141 elderly AF patients treated with RFCA from March 2017 to March 2021 were analyzed retrospectively. Patients were divided into the control group (n=117) and the observation group (n=24) according to the results of 6-month follow-up. Multiple Logistic regression analysis was used to analyze the risk factors of acute cerebrovascular events in elderly AF patients after RFCA. 【Results】Compared to the control group, the proportion of patients with persistent AF and patients with previous stroke increased in the observation group ( P<0.05). Previous stroke history and persistent AF were independent risk factors for acute cerebrovascular events in elderly AF patients after RFCA (OR=3.968,95%CI=1.472~10.697;OR=2.587, 95%CI=1.357~4.929, respectively, P<0.05). There were 24 cases of acute cerebrovascular events in the observation group. Of which, 13 cases had cerebral infarction within 24 hours, 2 cases occurred during operation, 7 cases occurred between 24 hours and 72 hours, 2 cases occurred between 8 days and 16 days, and 20 cases had cerebral infarction, there were 2 cases of transient cerebral ischemia attack and 2 cases of cerebral infarction with hemorrhage transformation. The NIHSS score was 1~20 (mean:7.52±6.37) in hospitalized patients with acute cerebrovascular events. When patients were discharged, they had the NIHSS score of 0~12 (mean: 3.95±3.63) with acute cerebrovascular events. There were 4 cases with complete recovery of neurological function. 【Conclusion】 Persistent AF and previous history of stroke are independent risk factors of acute cerebrovascular events after RFCA, which can increase the length of hospital stay and mortality. 2021 Vol. 38 (12): 1829-1832 [Abstract] ( 55 ) HTML (1 KB)  PDF (1144 KB)  ( 70 ) 1833 Rehabilitation Effect of Basic Motor Skills Intervention on Motor Disorders in Children with Autism Spectrum Disorders XIONG Ying, YANG Wei-hong, OUYANG Yun, et al DOI: 10.3969/j.issn.1671-7171.2021.12.021 【Objective】To explore the rehabilitation effect of basic motor skills intervention on motor disorders in children with autism spectrum disorder (ASD).【Methods】 A total of 100 children with ASD aged 4 ~ 12 who were treated in our hospital from November 2018 to January 2021 was randomly divided into observation group and control group, with 50 cases in each group.The control group received routine treatment of ASD and daily rehabilitation training according to the main symptoms. The observation group was given targeted basic motor skills intervention on the basis of the control group. Before and after the intervention, the gross motor development test was used to evaluate the motor function of ASD children, and the playground peer participation observation scale was used to evaluate the improvement of social skills of ASD children in the observation group, The autistic behavior checklist (ABC) was used to evaluate the symptoms of children in the two groups. 【Results】 There was no significant difference in the scores and total scores of motor skills and motor control skills between the two groups before the intervention (P>0.05); after the intervention, the scores and total scores of motor skills and motor control skills in the observation group were significantly higher than those before the intervention (P<0.05). Compared with the first week, the scores of loneliness and bystander in the observation group decreased significantly after the 10th week of intervention (P<0.05), and the scores of joint participation increased significantly (P<0.05), but there was no significant difference in the scores of social interaction states such as proximity, parallel, parallel perception and regular games (P>0.05). After the intervention, the total score of ABC and the scores of each factor in the observation group were significantly lower than those before the intervention (P<0.05), and the total scores of body movement factor, social communication factor and ABC in the observation group were significantly lower than those in the control group. 【Conclusion】 Basic motor skill intervention can significantly improve the motor skills of children with ASD, and has a positive effect on the social ability and clinical symptoms of children with ASD. 2021 Vol. 38 (12): 1833-1836 [Abstract] ( 83 ) HTML (1 KB)  PDF (1140 KB)  ( 209 ) 1837 Analysis of Serum A-SAA, sLR and sICAM-1 Levels in Patients with Behcet's Disease REN Hai-feng, WANG Shan-juan, WAN Jian, et al DOI: 10.3969/j.issn.1671-7171.2021.12.022 【Objective】To investigate the levels and significance of serum acute amyloid A (A-SAA), soluble leptin receptor (sLR) and soluble intercellular adhesion molecule (sICAM-1) in patients with Behcet's disease (BD). 【Methods】A total of 80 BD patients (the observation group) treated in our hospital were selected, and 80 healthy volunteers were selected as the control group. The serum A-SAA, sLR and sICAM-1 levels were measured between the two groups. 【Results】Serum A-SAA and sICAM-1 in the observation group were (117.81±34.49) mg/L and (171.18±32.28) μg/L, respectively, which were significantly higher than those in the control group (P<0.05), while the level of sLR was (70.02±21.12) ng/mL, which was significantly lower than that in the control group (P<0.05). There were no significant difference in serum A-SAA, sLR and sICAM-1 among patients of different sex, age and course of disease in the observation group (P>0.05). The serum sLR of the patients with joint involvement in the observation group was (56.68±20.16) ng/mL, which was significantly lower than that of the patients without joint involvement (P<0.05). After treatment, serum A-SAA and sICAM-1 in the observation group were significantly lower than those before treatment (P<0.05), while sLR was significantly higher than those before treatment (P<0.05). 【Conclusion】Serum A-SAA and sICAM-1 in BD patients increase significantly, while sLR decrease significantly, which may play a role in the occurrence and development of disease. The sLR level may be related to joint involvement. 2021 Vol. 38 (12): 1837-1839 [Abstract] ( 48 ) HTML (1 KB)  PDF (1119 KB)  ( 70 ) 1840 Effect of Early Rehabilitation Therapy on Motor Function Recovery in Children with Brain Injury YUAN Li-ping, HE Jin-hua, LIU Hua, et al DOI: 10.3969/j.issn.1671-7171.2021.12.023 【Objective】To explore the effect of early rehabilitation on the recovery of motor function in children with brain injury. 【Methods】 A Total of 49 children with traumatic brain injury with limb dysfunction were treated in our hospital, They were divided into control group (routine rehabilitation training, n=22) and observation group according to whether they were given early rehabilitation treatment (early rehabilitation treatment and routine rehabilitation training, n=27). The motor function scores and activities of daily living scores of children in the two groups were compared at 1 and 3 months of rehabilitation treatment, and the incidence of complications in the process of rehabilitation treatment was compared between the two groups. 【Results】 After 1 month of rehabilitation treatment, there was no significant difference in motor function scores and activities of daily living scores between the two groups (P>0.05); after 3 months of rehabilitation treatment, the scores of motor function and activities of daily living of children in the two groups were significantly higher than those in the rehabilitation treatment for 1 month, and the observation group was higher than the control group, the difference was statistically significant (P<0.05). The incidence of complications in the rehabilitation treatment of children in the observation group was 11.1% (3/27), significantly lower than 34.8% (8/22) in the control group, the difference was statistically significant (χ2=4.056,P=0.047<0.05). 【Conclusion】Early rehabilitation treatment can significantly improve motor function and activities of daily living in children with brain injury, and reduce the incidence of complications. 2021 Vol. 38 (12): 1840-1842 [Abstract] ( 46 ) HTML (1 KB)  PDF (1116 KB)  ( 84 ) 1843 Analysis of Retropharyngeal Lymph Node Metastasis and Clinical Characteristics in Patients with Hypopharyngeal Carcinoma HUANG Chang-qun, GAO Ying DOI: 10.3969/j.issn.1671-7171.2021.12.024 【Objective】To investigate the retropharyngeal lymph node metastasis and its clinical characteristics in patients with hypopharyngeal carcinoma. 【Methods】A total of 136 patients with hypopharyngeal cancer treated in our hospital were analyzed retrospectively. The TNM stage and clinical focus distribution of all patients with hypopharyngeal cancer were counted. According to the metastasis of retropharyngeal lymph nodes, the patients were divided into retropharyngeal lymph node positive group and retropharyngeal lymph node negative group. The clinical characteristics, postoperative regional recurrence and survival rate of the two groups were compared.【Results】Among 136 patients with hypopharyngeal carcinoma, 26 patients had lymph node metastasis (the metastasis group), accounting for 19.12%; and 110 patients had no lymph node metastasis (non metastasis group), accounting for 80.88%. There was no significant difference between the metastatic group and the non metastatic group in men patients with age ≥60, smoking, postoperative chemotherapy, hyperlipidemia and diabetes (P>0.05). The proportions of stage Ⅲ+Ⅳ, medium/high differentiation and distant metastasis in the metastasis group were higher than those in the non metastasis group (P<0.05). Stage Ⅲ+Ⅳ, medium/high differentiation and distant metastasis were the risk factors of lymph node metastasis in the metastasis group (OR=2.052, 3.536, 3.881, P<0.05). 【Conclusion】 The rate of lymph node metastasis is 19.12% in patients with pharyngeal cancer. Stage Ⅲ+Ⅳ, medium/high differentiation and distant metastasis are the risk factors of lymph node metastasis in the metastasis group. 2021 Vol. 38 (12): 1843-1845 [Abstract] ( 107 ) HTML (1 KB)  PDF (1116 KB)  ( 37 ) 1846 Application Value of CTP and DWI in Ischemic Penumbra of Acute Cerebral Infarction YANG Di, ZHOU Jia-hua, BAI Wan-sheng DOI: 10.3969/j.issn.1671-7171.2021.12.025 【Objective】 To investigate the value of whole brain CT perfusion imaging (CTP) and diffusion weighted imaging (DWI) in ischemic penumbra (IP) in patients with acute cerebral infarction (ACI).【Methods】 A total of 154 patients with ACI diagnosed and treated in our hospital from February 2019 to July 2020 was retrospectively analyzed. All patients underwent CTP and DWI examination. The CTP cerebral perfusion parameter values and DWI parameter values in different regions were compared. The correlation between lesions in different regions and DWI parameter values and CTP cerebral perfusion parameter values was analyzed by Spearman method, and the predictive value of various parameter values on IP of ACI patients was analyzed by ROC curve. 【Results】The mean diffusion coefficient (DCavg), fractional anisotropy (FA), apparent diffusion coefficient (ADC) and regional cerebral blood flow (rCBF) in the infarct central area were lower than those in IP area and contralateral mirror area(P<0.05). Transit time to the peak (TTP) and mean transit time (MTT) were longer than IP area and contralateral mirror area (P<0.05), DCavg value, FA value and ADC value of IP area were lower than those of contralateral mirror area, TTP and MTT were longer than contralateral mirror area, rCBF was lower than contralateral mirror area, and regional cerebellar blood volume (rCBV) was higher than that of infarct central area and contralateral mirror area. Through correlation analysis, the lesions in different areas were positively correlated with TTP and MTT (P<0.05), and negatively correlated with rCBV, rCBF, DCavg, FA and ADC (P<0.05). ROC curve analysis showed that the AUC of TTP, MTT, rCBV, rCBF, DCavg, FA, ADC and seven combined early prediction of ischemic penumbra of acute cerebral infarction were 0.622, 0.778, 0.941, 0.955, 0.943, 0.944, 0.952 and 0.997, respectively. 【Conclusion】 CTP combined with DWI has high diagnostic efficiency for IP in patients with ACI. 2021 Vol. 38 (12): 1846-1849 [Abstract] ( 76 ) HTML (1 KB)  PDF (1262 KB)  ( 86 ) 1850 Relationship between Smad7 Gene Rs4464148 Single Nucleotide Polymorphism and Cholangiocarcinoma XIANG Cai-ling, ZHOU Li-xue, CHEN Wan-ping DOI: 10.3969/j.issn.1671-7171.2021.12.026 【Objective】To investigate the relationship between single nucleotide polymorphism at rs4464148 of Smad7 Gene and the risk and prognosis of cholangiocarcinoma. 【Methods】The bile duct tissues of 70 patients with cholangiocarcinoma (observation group) and 40 patients with non neoplastic diseases (control group) who underwent surgical resection from January 2010 to January 2014 in Hunan Provincial People's Hospital were taken. All patients with cholangiocarcinoma did not receive adjuvant radiotherapy and chemotherapy before operation. The single nucleotide polymorphism of rs4464148 locus of Smad7 Gene in the observation group and the control group was detected by LDR-PCR, and the relationship between different genotypes and the risk and prognosis of cholangiocarcinoma was analyzed.【Results】There were AA, AG and GG genotypes at rs4464148 locus of Smad7 gene. The frequencies of AG/ GG genotype and G allele in the observation group were higher than those in the control group (P<0.05). Logistic multivariate regression analysis showed that the OR values of AG and AG/GG genotypes were 1.4 and 1.35 respectively. AG/GG genotype may be the pathogenic factor of cholangiocarcinoma. There was significant difference in the frequencies of AG/GG and AA genotypes in patients with lymph node metastasis, no recurrence or progression (P<0.05). The 3-year survival rate of patients with rs4464148 AG/GG genotype was lower than that of patients with AA genotype, but the difference was not statistically significant (P>0.05).【Conclusion】The AG/GG genotype at rs4464148 locus of Smad7 gene may be a risk factor for cholangiocarcinoma and may be an index to judge the prognosis of cholangiocarcinoma. 2021 Vol. 38 (12): 1850-1852 [Abstract] ( 55 ) HTML (1 KB)  PDF (1195 KB)  ( 58 ) 1853 Curative Observation of Different Time Periodontal Treatments after Root Canal Therapy in Patients with combined Periodontal and Pulp Disease LIN Xing-wei, WANG Ying-jie, WANG Bo DOI: 10.3969/j.issn.1671-7171.2021.12.027 【Objective】To explore the curative effect of periodontal treatment at different time after root canal therapy in patients with combined periodontal and pulp lesions. 【Methods】A total of 120 patients with combined periodontal and pulp lesions from October 2018 to October 2019 were selected as the research object. Patients were randomly divided into the observation group and the control group with 60 cases in each group. Both groups received periodontal treatment after root canal treatment. Patients in the observation group received periodontal treatment in 1 week after root canal treatment and patients in the control group received periodontal treatment in 3 weeks after the root canal treatment . The clinical efficacy of the two groups were compared 5 weeks after treatment, and the differences of periodontal probing depth (PD), attachment loss level (AL), gingival retreat (RG) and plaque index (PLI) before and after treatment were compared between the two groups as well. In addition, interleukin-8 (IL-8), interleukin-6 (IL-6) and interleukin-1 β (IL-1β) levels in gingival crevicular fluid and serum were compared between the two groups before and after operation. 【Results】The total effective rate of observation group was 91.66%(55/60), and there was no statistical significance compared with 88.33%(53/60) of control group (P>0.05). The levels of PD, AL and PLI in the two groups were significantly decreased and the level of RG was significantly increased after treatment, and the differences were statistically significant (P<0.05). The levels of PD, AL and PLI in the observation group were significantly lower than those in the control group after treatment, and the differences were statistically significant (P<0.05). Compared to before operation, levels of IL-8, IL-1β and IL-6 in gingival crevicular fluid and serum in both groups decreased significantly after operation with statistical significance (P<0.05), while levels of IL-8, IL-1β and IL-6 in observation group were lower than those in control group after operation and the difference was statistically significant (P<0.05). 【Conclusion】Root canal therapy combined with early periodontal treatment can better improve the levels of PD, AL, PLI, IL-8, IL-1β and IL-6 in patients of combined periodontal and pulp lesions, which is worthy of clinicians' attention. 2021 Vol. 38 (12): 1853-1856 [Abstract] ( 57 ) HTML (1 KB)  PDF (1149 KB)  ( 170 ) 1857 Effect of Schuell Language Rehabilitation Therapy Combined with rTMS on Poststroke Aphasia of Elderly Patients WEN Zhi-ling, YI Gui-ye, GUO Jin-lan DOI: 10.3969/j.issn.1671-7171.2021.12.028 【Objective】To explore the effect of Schuell language rehabilitation therapy combined with repetitive transcranial magnetic stimulation (rTMS) in the treatment of aphasia in elderly stroke patients. 【Methods】A total of 70 patients with poststroke aphasia who were treated in our hospital from August 2017 to August 2020 were selected in the study. According to random digital table, patients were divided into the control group and the observation group, with 35 cases in each group. The control group was given Schuell language rehabilitation therapy, while the observation group was given rTMS in addition to Schuell language rehabilitation therapy. The clinical efficacy, language function (naming, auditory comprehension, spontaneous speech and retelling), aphasia quotient (AQ), Montreal Cognitive Assessment Scale (MoCA score) and communication ability of daily language scale (CADL) score were compared between the two groups. 【Results】After treatment, the total effective rate in the observation group was 91.43% (32/35),which was higher than 65.71% (23/35) in the control group; And the difference was statistically significant(P<0.05).Compared to before treatment, patients in both groups had higher scores of language function (naming, listening comprehension, retelling, spontaneous speech), AQ score, MoCA score and CADL score after treatment(P>0.05).After treatment, the scores of language function (naming, listening comprehension, retelling, spontaneous speech), AQ score, MoCA score and CADL score in the observation group were significantly higher than those in the control group(P<0.05). 【Conclusion】Schuell language rehabilitation therapy combined with rTMS in the treatment of aphasia after stroke has a good clinical effect, can improve the language function of patients, improve the ability of daily communication and cognitive function of patients. 2021 Vol. 38 (12): 1857-1859 [Abstract] ( 61 ) HTML (1 KB)  PDF (1123 KB)  ( 141 ) 1860 Correlation Analysis of Serum Tumor Markers and Immunohistochemical Indicators with Clinicopathological Features of Gastric Cancer LI Ji-bin, WANG Rui, TANG Shui-ping DOI: 10.3969/j.issn.1671-7171.2021.12.029 【Objective】To investigate the correlation of immunohistochemistry and tumor markers with clinicopathological characteristics of gastric cancer. 【Methods】Retrospective analysis of all clinical data of 152 patients with gastric cancer treated in our hospital from December 2015 to December 2019 were studied. The relationship of the expression of human epidermal growth factor receptor (Her-2), epidermal growth factor receptor (EGFR), antigen ki67 (Ki67), tumor markers carcinoembryonic antigen (CEA), sugar chain antigen (CA125 and CA19-9) with the clinicopathological characteristics of patients with gastric cancer. 【Results】The expressions of HER-2, EGFR and Ki67 were correlated with lymphatic metastasis, high differentiation and TNM stages Ⅲ and IV (P<0.05). The levels of CEA, CA125 and CA19-9 in patients with tumor lymphatic metastasis were significantly higher than those in patients without metastasis (P<0.05). Taking the tumor diameter 2.4cm as the boundary,the levels of CEA, CA125 and CA19-9 in serum of patients with increased tumor diameter were significantly higher than those with smaller tumor diameter (P<0.05). The level of CA125 decreased with the increase of pathological differentiation (P<0.05). In patients with gastric cancer, the expression of CEA, CA125 and CA199 in stage Ⅱ, Ⅲ and Ⅳ was higher than that in stage Ⅰ(P<0.05), the expression of CEA, CA125 and CA199 in stage Ⅲ and Ⅳ was higher than that in stage Ⅱ (P<0.05), and the expression of CEA, CA125 and CA199 in stage Ⅳ was higher than that in stage Ⅲ(P<0.05). 【Conclusion】Immunohistochemistry and tumor markers can be used as useful reference for the diagnosis of gastric cancer patients, and provide a theoretical basis for the early diagnosis and treatment of gastric cancer patients. 2021 Vol. 38 (12): 1860-1863 [Abstract] ( 45 ) HTML (1 KB)  PDF (1141 KB)  ( 58 ) 1864 Evaluation of Cardiac Autonomic Nerve Function in Patients with Primary Hyperthyroidism in Terms of Dynamic Electrocardiogram ZHU Yao, RUAN Xue-lian, QIAN Dong, et al DOI: 10.3969/j.issn.1671-7171.2021.12.030 【Objective】Evaluation of cardiac autonomic nerve function in patients with primary hyperthyroidism in terms of dynamic electrocardiogram.【Methods】A total of 44 patients with primary hyperthyroidism admitted to Jiangsu Hospital of Traditional Chinese Medicine from January 2018 to December 2019 were selected as the observation group, while 44 people matched with age and sex at the same period were selected as the control group. The changes of heart rate(HR) variability(SDNN, SDNN Idx, PNN50, rMSSD, SDANN, triangle index); cardiac chronological function indexes (maximum HR, minimal HR, difference between the maximum and minimal HR, 24-hour average HR, daytime average HR, nocturnal average HR and circadian rhythm of HR) were compared in the two groups, and the correlation between chronological function indexes and heart rate variability(HRV) indexes was analyzed in the observation group. 【Results】 (1) The time-domain indexes of HRV including SDNN, SDNN Idx, PNN50, rMSSD, SDANN and triangle index in the observation group were significantly lower than those in the control group (P<0.05). (2) There was no significant difference in the maximum HR between two groups (P=0.138), however, minimal HR and difference between the maximum and minimal HR in the observation group were higher than those in the control group (P<0.001,P=0.004). 24-hour average HR, average daytime HR and average nighttime HR in the observation group were higher than those in the control group (P<0.05). (3) In the observation group, all the chronotropic functional indexes except for maximum HR were mainly correlated with SDNN and triangle index. SDNN was negatively correlated with minimal HR (r=-0.771) and with nocturnal average HR (r=-0.790), while the triangle index was negatively correlated with minimal HR (r=-0.729) and nocturnal average HR (r=-0.770). The slowest heart rate, 24-hour average heart rate, night average heart rate of patients with hyperthyroidism were significantly correlated with SDNN, SDANN, rMSSD and triangular index (all P<0.05), and the difference between the fastest and slowest heart rate was significantly correlated with SDNN and triangular index (All P<0.05), there was a significant correlation between the average daytime heart rate and SDNN, rMSSD and triangle index (all P<0.05). 【Conclusion】There is a significant imbalance in the regulation of cardiac autonomic nerve system in patients with hyperthyroidism, which is characterized by double damage of sympathetic nerve and vagus nerve, in which the over activation of sympathetic nerve is more serious. 2021 Vol. 38 (12): 1864-1866 [Abstract] ( 48 ) HTML (1 KB)  PDF (1121 KB)  ( 44 ) 1867 Characteristics of Carbapenem-resistant Pseudomonas Aeruginosa (CRPA) Resistance Genes and Heterogeneous Resistance to Polymyxin HE Xin-wen, MA Long DOI: 10.3969/j.issn.1671-7171.2021.12.031 【Objective】To analyze the characteristics of carbapenem resistant pseudomonas aeruginosa (CRPA) and the status of heterogeneous resistance to polymyxin. 【Methods】A total of 76 CRPA strains were collected. Genes related to drug resistance were detected by PCR and the sensitivity of the strains to polymyxin was also detected. Of which, 15 strains were selected for population profiling to analyze the heterogeneity of polymyxin, and the combination drug experiment was used to screen the medication plan. 【Results】Out of 76 CRPA strains, result showed that there were 15 strains (19.74%) IMP positive, 8 strains (10.53%) VIM positive, 6 starins (7.89%)SPM positive, 12 stains (15.79%)OXA-10 positive, and45 strains (59.21%) OprD2 deletion. A total of 75 strains (98.68%) were sensitive to polymyxin. Among the 15 strains of CRPA, 5 strains (33.33%) had heterogeneous resistance, 3 strains (20.00%) had heterogeneity, and 7 strains (46.67%) had no heterogeneity. The combination regimen of polymyxin with biapenem had the best effect. 【Conclusion】The production of penicillene-like enzymes and the loss of outer membrane porin are one of the main mechanisms of CRPA resistance. CRPA is highly sensitive to polymyxin with heterogeneous and heterogeneous drug resistance. Drug combination can enhance the sensitivity of heterogeneous drug-resistant strains. 2021 Vol. 38 (12): 1867-1870 [Abstract] ( 66 ) HTML (1 KB)  PDF (1145 KB)  ( 122 )

Copyright © Editorial Board of JOURNAL OF CLINICAL RESEARCH Supported by:Beijing Magtech