Effect of Drug-eluting Beads Transcatheter Arterial Chemoembolization and Surgical Resection on Short-term and Long-term Efficacy of Stage Ⅱb Primary Liver Cancer
WANG Song, WANG Wen-chao, YANG Jun-chi, et al
Shanghai Yangpu District Central Hospital(Yangpu Hospital,Tongji University),Shanghai 200090
Abstract 【Objective】To compare the near-and long-term efficacy of drug-loaded microspheres through transcatheter hepatic arterial embolization (TACE) and surgical resection for stage Ⅱb primary liver cancer. 【Methods】A total of 68 patients with primary liver cancer of stage Ⅱb were random divided into groups A and B, with 34 cases each. The group B underwent surgical resection, while group A received CalliSpheres drug-eluting beads transarterial chemoembolization (DEB-TACE). Both groups received transarterial chemoembolization after relapse. The progression-free survival (DFS), overall survival (OS), blood biochemical data before and after treatment, complications, and short-term efficacy were compared between the two groups. 【Results】There were no significant differences in objective remission rate and the disease control rate at 1 month and at 3 months after treatment between the two groups (P>0.05). Compared with before treatment, the levels of VEGF, bFGF, AFP, TBIL, AST and ALT in both groups decreased after 3 months and after 6 months of treatment(P<0.05), while ALB increased after 3 months of treatment(P<0.05). There was no significant difference in the average cumulative number of TACE treatments between the two groups within 2 years after treatment (P>0.05). There was no significant difference in the incidence of complications between the two groups (P>0.05). There were no significant differences in cumulative DFS rate and cumulative OS rate between group A and group B (P>0.05). 【Conclusion】DEB-TACE is effective in the treatment of stage Ⅱb primary liver cancer, which is equivalent to the effect and prognosis of surgical resection, while DEB-TACE can reduce the number of TACE treatments and reduce the cost of hospitalization.
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2021, Vol. 38 
