血清心肌损伤标志物及炎症因子与新生儿窒息严重程度的相关性

doi:10.3969/j.issn.1671-7171.2024.02.032

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Abstract 【Objective】To explore the correlation between serum myocardial injury markers and inflammatory factors with the severity of neonatal asphyxia. 【Methods】A total of 120 newborns with asphyxia born in our hospital from September 2019 to September 2022 (observation group) and 50 healthy newborns (control group) were selected. Two groups of study subjects were compared in terms of serum myocardial injury biomarkers [calcin I(cTnI), creatine kinase (CK), and creatine kinase isoenzyme (CK-MB)] and inflammatory factors [C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α(TNF-α)],and the relationship between serum cTnI, CK, CK-MB, CRP, IL-6, TNF-α levels and the severity of neonatal asphyxia was analyzed. 【Results】The serum levels of cTnI, CK, CK-MB, CRP, IL-6, and TNF-αin the observation group were higher than those in the control group, and the differences were statistically significant (P<0.05).The serum levels of cTnI, CK, and CK-MB in the severe asphyxia group were higher than those in the mild asphyxia group on the 1st and 7th day of birth (P<0.05), and the serum levels of cTnI, CK, and CK-MB on the 7th day of birth were lower than those on the 1st day of birth in the two groups, with statistical significance (P<0.05). The serum levels of CRP, IL-6, and TNF-α in the severe asphyxia group were significantly higher than those in the mild asphyxia group on the 1st and 7th day of birth (P<0.05). The serum levels of CRP, IL-6, and TNF-α in the two groups were lower on the 7th day of birth than on the 1st day of birth, and the difference was statistically significant (P<0.05). Spearman correlation analysis showed that serum levels of cTnI, CK, CK-MB, CRP, IL-6, TNF-αwere positively correlated with the severity of neonatal asphyxia (all P<0.05). 【Conclusion】The levels of myocardial injury markers and inflammatory factors in newborns with asphyxia are abnormally elevated, and the levels of myocardial injury markers and inflammatory factors are positively correlated with the severity of neonatal asphyxia.

Key words： Asphyxia Neonatorum Troponin/BL Creatine Kinase, MB Form/BL Chemokines/BL

Received: 16 July 2022

PACS:

R722.12

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	SHEN Jie
	ZHANG Weixing
	WU Junbao

Cite this article:

SHEN Jie,ZHANG Weixing,WU Junbao. The Correlation between Serum Myocardial Injury Markers and Inflammatory Factors with the Severity of Neonatal Asphyxia[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(2): 273-275.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2024.02.032 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2024/V41/I2/273

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