The Effect of Outdoor Aerobic Exercise Combined with Aripiprazole on Lipid Metabolism and Event-related Potential P300 in Elderly Obese Schizophrenia Patients
SHAN Xiaohei, ZHANG Fusong, RUI Jinghua
The Fifth People's Hospital of Kaifeng, Kaifeng Henan 475000
Abstract 【Objective】To explore the effects of outdoor aerobic exercise combined with aripiprazole on lipid metabolism and event related potential (P300) in elderly obese patients with schizophrenia (SCH). 【Methods】A total of 114 elderly obese SCH patients admitted to our hospital from July 2019 to July 2021 were selected and randomly divided into a control group and an observation group using a random number table method, with 57 cases in each group. The control group was treated with aripiprazole, while the observation group received outdoor aerobic exercise treatment in addition to the control group. We compared the clinical efficacy, BPRS scores, SSPI scores, P300(latency, amplitude), lipid metabolism indicators [triglycerides (TG), glutamic acid (GLU), low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C)], and incidence of adverse reactions between two groups. 【Results】The clinical effective rate of the observation group was 94.74%, which was higher than the control group's 80.70%, and the difference was statistically significant (P<0.05). After treatment, the BPRS scores of both groups were lower than before treatment, and the observation group was lower than the control group (P<0.05); The SSPI scores of the two groups were higher than before treatment, and the observation group was higher than the control group (P<0.05). After treatment, the P300 latency in both groups was lower than before treatment, and the observation group was lower than the control group (P<0.05); After treatment, the amplitude of P300 waves in both groups was higher than before treatment, and the observation group was higher than the control group (P<0.05). After treatment, the levels of GLU, TG, and LDL-C in both groups were higher than before treatment, and the increase in the observation group was smaller than that in the control group (P<0.05); After treatment, the HDL-C levels in both groups were lower than before treatment, and the decrease in the observation group was smaller than that in the control group (P<0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】 The combination of aripiprazole and outdoor aerobic exercise has a significant effect on the treatment of elderly obese SCH, which can improve clinical symptoms, promote social function reconstruction, regulate lipid metabolism, and is worthy of clinical reference.
SHAN Xiaohei,ZHANG Fusong,RUI Jinghua. The Effect of Outdoor Aerobic Exercise Combined with Aripiprazole on Lipid Metabolism and Event-related Potential P300 in Elderly Obese Schizophrenia Patients[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(2): 276-279.
[1] BIGHELLI I,RODOLICO A,PITSCHEL-WALZ G,et al.Psychosocial treatments for relapse prevention in schizophrenia: study protocol for a systematic review and network meta-analysis of randomised evidence[J].BMJ Open,2020,10(1):35073.
[2] 李莉霞,杜晓莉,李正发,等.阿立哌唑联合喹硫平对器质性精神障碍病人糖脂代谢及内环境的影响[J].中西医结合心脑血管病杂志,2021,19(18):3245-3248.
[3] 蒋秀兰,戴福强,秦淑国,等.利培酮联合小剂量阿立哌唑对精神分裂症患者血清神经递质、糖脂代谢及BMI的影响[J].现代生物医学进展,2020,20(7):1373-1376.
[4] 林春燕,周红蕊,黎顺成,等.探讨奥氮平对首发精神分裂症伴肥胖患者认知功能、糖脂代谢及相关激素指标水平的影响[J].中国医院药学杂志,2019,39(9):954-958.
[5] 尹利军,杨亚南,林小晶,等.雄激素及其受体在有氧运动改善肥胖及肥胖相关疾病症状、血糖血脂中的作用[J].中国运动医学杂志,2020,39(7):552-561.
[6] 中华医学会精神科分会.中国精神障碍分类与诊断标准(CGMD-3)[M].3版.济南:山东科学技术出版社,2001.
[7] 王洋,王菲,魏胜男,等.精神分裂症及其遗传高危人群血浆炎性细胞因子水平与临床症状的相关研究[J].国际精神病学杂志,2020,47(4):670-673.
[8] 刘志伟,夏磊,张雨龙,等.精神分裂症患者血浆食欲素A、瘦素水平与肥胖的相关性分析[J].安徽医科大学学报,2020,55(6):951-954.
[9] KIM D D,BARR A M,LIAN L,et al.Efficacy and tolerability of aripiprazole versus D2 antagonists in the early course of schizophrenia:A systematic review and meta-analysis[J].NPJ Schizophr,2021,7(1):29.
[10] 杜健,郑月,刘薇,等.有氧运动改善精神分裂症患者认知功能的Meta分析[J].中华精神科杂志,2021,54(3):211-218.
[11] 赵婧,郭银淼,李梦楠,等.θ短阵快速脉冲重复经颅磁刺激对老年慢性精神分裂症阴性症状及认知功能的影响[J].中华行为医学与脑科学杂志,2021,30(7):577-583.
[12] 覃志松,陈琦,刘颖华,等.户外有氧运动结合精神康复治疗对住院慢性精神分裂症患者康复效果的影响[J].反射疗法与康复医学,2020, 24(1):19-21.
[13] 李鲜鲜,张平,王芳,等.半封闭管理联合农场劳动对精神分裂症长期住院患者阴性症状的影响[J].神经疾病与精神卫生,2020,20(1):26-31.
[14] 高景娜,崔利军,张旭静,等.阿立哌唑、氨磺必利及奥氮平对精神分裂症患者糖脂代谢及性激素水平的影响[J].中国医师杂志,2020,22(9):1395-1398.
2024, Vol. 41 
