Abstract 【Objective】To explore the relationship between serum inflammatory factor levels and cognitive function in patients with obsessive-compulsive disorder. 【Methods】A total of 252 patients with obsessive-compulsive disorder who were treated in our hospital were divided into the mild obsessive-compulsive disorder group(n=125) and the severe obsessive-compulsive disorder group(n=127) according to the Yale-Brown obsessive-compulsive scale(Y-BOCS). In the same period, 100 healthy people who came to our hospital for physical examination were recruited to the control group. The changes of serum levels of interleukin-2(IL-2), levels of interleukin-6(IL-6), tumor necrosis factor-alpha(TNF-α) and serotonin 5-hydroxytryptamine(5-HT) levels were compared among different groups. The cognitive function of each group using the Neurocognitive Battery test(MCCB) was evaluated and compared as well.Spearman correlation test was used to analyzed the relationship of cognitive function score with serum levels of IL-2, IL-6, IL-8 and TNF-α. 【Results】Information processing speed, visuospatial working memory, visual memory, reasoning and problem-solving scores, and 5-HT level in the obsessive-compulsive group were lower than those in the control group(P<0.05). The serum levels of IL-2, IL-6, IL-8 and TNF-α in pre-treated obsessive-compulsive group were higher than those post-treated obsessive-compulsive group, which was greater than the control group(P<0.05). The information processing speed, visuospatial working memory, visual memory, reasoning and problem-solving scores, and 5-HT level before and after treatment in the severe obsessive-compulsive group were lower than those in the mild obsessive-compulsive group(P<0.05), while the levels of IL-2, IL-6, IL-8 and TNF-α before and after treatment in the severe obsessive-compulsive group were significantly higher than those in the mild obsessive-compulsive group(P<0.05). Spearman test showed that serum levels of IL-2, IL-6, IL-8 and TNF-α were negatively correlated with information processing speed, visual spatial working memory, visual memory, reasoning and problem-solving scores in patients with obsessive-compulsive disorder(P<0.05). 【Conclusion】Serum levels of IL-2, IL-6, IL-8 and TNF-α are important inflammatory indicators that reflect the cognitive function of patients with obsessive-compulsive disorder. IL-2, IL-6, IL-8 and TNF-α levels are negative correlation with the cognitive function score of patients with obsessive-compulsive disorder. Thus they can be used as an auxiliary diagnostic index to detect the cognitive impairment of patients with obsessive-compulsive disorder.
CHEN Min,SUN Xiaolan,JIANG Danma. Relationship between Serum Inflammatory Factor Level and Cognitive Function in Patients with Obsessive-compulsive Disorder[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(3): 348-351.
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2024, Vol. 41 
