清宣止咳颗粒联合西药治疗肺炎支原体肺炎的临床疗效及对患儿肺功能、免疫功能的影响

doi:10.3969/j.issn.1671-7171.2024.02.031

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Abstract 【Objective】To explore the clinical efficacy of Qingxuan Zhike Granules combined with Western medicine in the treatment of Mycoplasma pneumoniae pneumonia and its impact on lung function and immune function in children. 【Methods】A total of 112 children with Mycoplasma pneumoniae pneumonia admitted to our hospital from September 2020 to October 2022 were selected and randomly divided into an observation group and a control group using a random number table method, with 56 cases in each group. The control group was treated with conventional western medicine, while the observation group was treated with Qingxuan Zhike Granules on the basis of the control group. Both groups were treated for 2 weeks.The two groups were compared in terms of efficacy, symptom disappearance time, and pulmonary ventilation function before and after treatment [forced expiratory volume at 1 second (FEV₁), forced vital capacity (FVC), maximum expiratory flow rate L (PEF)], serum immunoglobulin indicators [immunoglobulin M (IgM), immunoglobulin G (IgG), immunoglobulin A (IgA)],Toll like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), and nuclear transcription factor-κB (NF-κB) levels. The occurrence of adverse reactions had been counted. 【Results】The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). The observation group had shorter fever relief time, disappearance time of shortness of breath, disappearance time of cough, and disappearance time of lung rales compared to the control group, and the differences were statistically significant (P<0.05). After treatment, the FEV₁, FVC, and PEF of the two groups of patients were higher than before treatment, and the observation group was higher than the control group, with statistical significance (P<0.05); The serum levels of IgM, IgG, and IgA in the two groups were higher than before treatment, while the observation group was higher than the control group, with statistical significance (P<0.05); The expression levels of TLR4, MyD88, and NF-κB in the serum of the two groups were lower than before treatment, and the observation group was lower than the control group, with statistical significance (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups of children (P>0.05). 【Conclusion】The combination of Qingxuan Zhike Granules and Western medicine has a good clinical efficacy in the treatment of Mycoplasma pneumoniae pneumonia, which can effectively improve the lung and immune functions of children, inhibit the expression of TLR4/MyD88, and is safe.

Key words： Pneumonia, Mycoplasma/ ZJ Respiratory Function Tests Immunologic Tests

Received: 31 May 2023

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R725.631

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	QIN Junfeng
	XU Guochao
	AN Yunying
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Cite this article:

QIN Junfeng,XU Guochao,AN Yunying, et al. Clinical Efficacy of Qingxuan Zhike Granules Combined with Western Medicine in the Treatment of Mycoplasma Pneumoniae Pneumonia and its Impact on Lung and Immune Function in Children[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(2): 269-272.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2024.02.031 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2024/V41/I2/269

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