Abstract：【Objective】 To investigate the analgesic effect of ropivacaine combined with sufentanil on epidural anesthesia(CSEA) in women undergoing painless delivery.【Methods】 A total of 100 parturients undergoing painless delivery were randomly divided into a control group and an observation group, with 50 cases in each group. The control group received ropivacaine via CSEA, while the observation group received a combination of ropivacaine and sufentanil via CSEA. The following outcomes were compared between the two groups:duration of labor stages, analgesic effect [visual analogue scale(VAS) scores], serum biomarkers [prolactin(PRL), adiponectin(APN), tissue-type plasminogen activator(t-PA)], delivery outcomes, and incidence of adverse reactions.【Results】 The duration of the first, second, and third stages of labor was significantly shorter in the observation group than in the control group(P<0.05). The onset time of effective analgesia was shorter, and the duration of analgesia was longer in the observation group. VAS scores at 5, 15, 30, and 60 minutes after analgesia in the observation group were significantly lower than those in the control group(P<0.05). Serum levels of PRL and APN in the observation group were higher than those in the control group, while t-PA level was lower in the observation group compared to the control group(P<0.05). The rate of spontaneous vaginal delivery was higher in the observation group(P<0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).【Conclusion】 Ropivacaine combined with sufentanil for CSEA can significantly shorten labor duration, enhance analgesic efficacy, improve the rate of spontaneous delivery, and demonstrate good safety in painless labor.
2025, Vol. 42 
