Abstract:【Objective】To explore the influencing factors and intervention measures for postoperative incision infection in natural delivery parturients undergoing episiotomy.【Methods】A total of 200 natural delivery parturients who underwent episiotomy in our hospital from January 2021 to January 2022 were selected and divided into an infection group (n=89) and a non-infection group (n=111) based on whether incision infection occurred postoperatively. Multivariate logistic regression analysis was used to identify the risk factors for postoperative incision infection in natural delivery parturients after episiotomy.【Results】Multivariate logistic regression analysis showed that body mass index (BMI) >28 kg/m2, history of diabetes, reproductive tract infection, vaginal examinations >3 times, operative time >30 minutes, and premature rupture of membranes were independent risk factors for postoperative incision infection in natural delivery parturients undergoing episiotomy. 【Conclusion】BMI >28 kg/m2, history of diabetes, reproductive tract infection, vaginal examinations >3 times, operative time >30 minutes, and premature rupture of membranes are independent risk factors for postoperative incision infection in natural delivery parturients after episiotomy. Targeted nursing interventions for these risk factors can help reduce the risk of incision infection.