Abstract:【Objective】To investigate the occurrence and influencing factors of hypoglycemia in obese patients following spinal anesthesia.【Methods】 Eighty obese patients who underwent spinal anesthesia were enrolled in the study. They were divided into two groups based on whether they developed hypoglycemia after anesthesia: the hypoglycemia group (32 cases) and the non-hypoglycemia group (48 cases). Relevant clinical data of all patients were collected and analyzed. A preliminary screening of risk factors for hypoglycemia was conducted using univariate analysis of variance, followed by a multivariate logistic regression analysis to identify independent risk factors for hypoglycemia in obese patients after anesthesia.【Results】Univariate analysis showed that a high body mass index (BMI), the presence of diabetes, hypertension, prolonged surgery duration, and extended preoperative fasting time were all associated with the occurrence of hypoglycemia in obese patients following spinal anesthesia (P<0.05). Multivariate Logistic regression analysis revealed that a high BMI, the presence of diabetes, and prolonged surgery duration were independent risk factors for hypoglycemia after anesthesia in obese patients (P<0.05).【Conclusion】 For obese patients, especially those with complications such as diabetes, strict weight control and careful management of surgery duration before undergoing spinal anesthesia are essential to effectively reduce the risk of postoperative hypoglycemia.