孕中期子宫动脉搏动指数联合血清β-HCG水平对孕妇发生晚发型胎儿宫内生长受限的预测价值

doi:10.3969/j.issn.1671-7171.2024.08.001

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摘要【目的】探讨孕中期子宫动脉搏动指数(PI)联合血清β亚单位人绒毛膜促性腺素(β-HCG)水平对孕妇发生晚发型胎儿宫内生长受限的预测价值。【方法】选择2019年1月至2023年12月在西安市人民医院(西安市第四医院)定期产检的179例孕妇,根据是否发生晚发型胎儿宫内生长受限分为晚发型胎儿宫内生长受限组(于妊娠32周以后首次诊断为胎儿生长受限,A组)和非晚发型胎儿宫内生长受限组(B组),检测两组孕妇孕中期PI、β-HCG水平,采用Logistic多因素回归分析孕妇发生晚发型胎儿宫内生长受限的危险因素,分析孕中期子宫动脉PI联合β-HCG水平对孕妇发生晚发型胎儿宫内生长受限的预测价值。【结果】179例孕妇发生晚发型胎儿宫内生长受限31例,发生率为17.32%。两组年龄、孕次、妊娠期高血压家族史、收缩压、总胆固醇(TC)、白蛋白水平比较,差异无统计学意义(P>0.05)。A组PI、β-HCG水平及分娩孕周高于B组(P<0.05)。Logistic多因素回归分析结果显示:PI、β-HCG水平高为孕妇发生晚发型胎儿宫内生长受限的危险因素 (P<0.05)。受试者工作特征(ROC)曲线结果显示:PI联合β-HCG水平预测孕妇发生晚发型胎儿宫内生长受限的曲线下面积(AUC)值为0.937,显著高于单独预测值(P<0.05)。【结论】PI、β-HCG与孕妇发生晚发型胎儿宫内生长受限密切相关,两者可用于预测孕妇发生晚发型胎儿宫内生长受限,且联合预测效能更高。

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	李西娜
	徐宁
	王富丽

关键词 ：胎儿生长迟缓, 子宫/血液供给, 动脉/影像诊断, 绒毛膜促性腺激素,β亚单位,人/血液

Abstract：【Objective】To investigate the value of uterine artery pulsation index (PI) combined with serum β-subunit human chorionic gonadotropin (β-HCG) level in predicting intrauterine growth restriction in late-onset fetuses during the second trimester. 【Methods】A total of 179 pregnant women were selected from Xi'an People's Hospital(Xi'an Fourth Hospital) from January 2019 to December 2023. According to the occurrence of growth restriction, they were divided into the late-onset intrauterine growth restriction group and non-late-onset intrauterine growth restriction group. PI and β-HCG were measured during the second trimester. Logistic regression was used to analyze the risk factors of intrauterine growth restriction in late-onset fetuses. We also analyzed the value of uterine artery ultrasound PI combined with β-HCG in predicting late-onset fetal intrauterine growth restriction in the second trimester. 【Results】There were 31 cases of late-onset intrauterine growth restriction (17.32%) in pregnant women, which were classified as late-onset intrauterine growth restriction group and 148 cases of non-late-onset intrauterine growth restriction group. There was no statistical significance in age, gestational time, family history of hypertension during pregnancy, systolic blood pressure, TC and albumin between late and non-late intrauterine growth restriction group (P>0.05). The levels of PI, β-HCG and gestational age in the late intrauterine growth restriction group were higher than those in the non-late intrauterine growth restriction group (P<0.05). The occurrence of late-onset fetal intrauterine growth restriction was taken as the dependent variable, and PI and β-HCG were taken as independent variables for Logistic multivariate regression analysis (assignment: PI and β-HCG levels were continuous variables), the results showed that PI and β-HCG were risk factors for late-onset intrauterine growth restriction (P<0.05). ROC curve results showed that the AUC value of PI combined with β-HCG in predicting late-onset intrauterine growth restriction was 0.937, which was higher than that predicted alone (P<0.05). 【Conclusion】Both PI and β-HCG are closely related to intrauterine growth restriction of late-onset fetuses, and they can be used to predict intrauterine growth restriction of late-onset fetuses, while the prediction efficiency of PI and β-HCG combined value is higher than either PI or β-HCG alone.

Key words： Fetal Growth Retardation Uterus/BS Arteries/DG Chorionic Gonadotropin, beta Subunit, Human/BL

收稿日期: 2023-05-16

中图分类号:

R714.431

基金资助:陕西省重点研发计划一般项目-社会发展领域(编号:2022SF-278);西安市卫生健康委员会科研项目一般研究项目(编号:2023yb12)

通讯作者: ** E-mail:1163334531@qq.com

引用本文:

李西娜, 徐宁, 王富丽. 孕中期子宫动脉搏动指数联合血清β-HCG水平对孕妇发生晚发型胎儿宫内生长受限的预测价值[J]. 医学临床研究, 2024, 41(8): 1121-1123.
LI Xina, XU Ning, WANG Fuli. Predictive Value of Uterine Artery Pulse Index Combined with Serum β-HCG Level in Late-Onset Fetal Intrauterine Growth Restriction in the Second Trimester. JOURNAL OF CLINICAL RESEARCH, 2024, 41(8): 1121-1123.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2024.08.001 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2024/V41/I8/1121

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