Predictive Value of Uterine Artery Pulse Index Combined with Serum β-HCG Level in Late-Onset Fetal Intrauterine Growth Restriction in the Second Trimester
LI Xina, XU Ning, WANG Fuli
Department of Ultrasonic Imaging Center, Xi'an People's Hospital(Xi'an Fourth Hospital), Xi'an Shaanxi 710000
Abstract：【Objective】To investigate the value of uterine artery pulsation index (PI) combined with serum β-subunit human chorionic gonadotropin (β-HCG) level in predicting intrauterine growth restriction in late-onset fetuses during the second trimester. 【Methods】A total of 179 pregnant women were selected from Xi'an People's Hospital(Xi'an Fourth Hospital) from January 2019 to December 2023. According to the occurrence of growth restriction, they were divided into the late-onset intrauterine growth restriction group and non-late-onset intrauterine growth restriction group. PI and β-HCG were measured during the second trimester. Logistic regression was used to analyze the risk factors of intrauterine growth restriction in late-onset fetuses. We also analyzed the value of uterine artery ultrasound PI combined with β-HCG in predicting late-onset fetal intrauterine growth restriction in the second trimester. 【Results】There were 31 cases of late-onset intrauterine growth restriction (17.32%) in pregnant women, which were classified as late-onset intrauterine growth restriction group and 148 cases of non-late-onset intrauterine growth restriction group. There was no statistical significance in age, gestational time, family history of hypertension during pregnancy, systolic blood pressure, TC and albumin between late and non-late intrauterine growth restriction group (P>0.05). The levels of PI, β-HCG and gestational age in the late intrauterine growth restriction group were higher than those in the non-late intrauterine growth restriction group (P<0.05). The occurrence of late-onset fetal intrauterine growth restriction was taken as the dependent variable, and PI and β-HCG were taken as independent variables for Logistic multivariate regression analysis (assignment: PI and β-HCG levels were continuous variables), the results showed that PI and β-HCG were risk factors for late-onset intrauterine growth restriction (P<0.05). ROC curve results showed that the AUC value of PI combined with β-HCG in predicting late-onset intrauterine growth restriction was 0.937, which was higher than that predicted alone (P<0.05). 【Conclusion】Both PI and β-HCG are closely related to intrauterine growth restriction of late-onset fetuses, and they can be used to predict intrauterine growth restriction of late-onset fetuses, while the prediction efficiency of PI and β-HCG combined value is higher than either PI or β-HCG alone.
李西娜, 徐宁, 王富丽. 孕中期子宫动脉搏动指数联合血清β-HCG水平对孕妇发生晚发型胎儿宫内生长受限的预测价值[J]. 医学临床研究, 2024, 41(8): 1121-1123.
LI Xina, XU Ning, WANG Fuli. Predictive Value of Uterine Artery Pulse Index Combined with Serum β-HCG Level in Late-Onset Fetal Intrauterine Growth Restriction in the Second Trimester. JOURNAL OF CLINICAL RESEARCH, 2024, 41(8): 1121-1123.
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2024, Vol. 41 
