Abstract：【Objective】To investigate the clinical efficacy of infliximab combined with escitalopram oxalate in the treatment of patients with depression and rheumatoid arthritis. 【Methods】A total of 180 patients with depression combined with rheumatoid arthritis admitted to Wuxi Mental Health Center from January 2018 to March 2022 were selected and divided into the control group and the observation group according to random number table method, with 90 cases in each group. The control group was treated with escitalopram oxalate tablets on the basis of basic treatment; The observation group was additionally treated with infliximab for 30 weeks. The clinical efficacy, occurrence of adverse reactions, pain score, depression score, erythrocyte subsidence rate (ESR), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), rheumatoid factor (RF), homocysteine (Hcy), brain-derived neurotrophic factor (BDNF), 5-hydroxytryptophan (5-HT) and dopamine were compared between the two groups cortisol levels.【Results】 6 cases fell off in the observation group, and 84 cases were included in the analysis. In the control group, 4 cases fell off, and 86 cases were included in the analysis. After treatment, the total effective rate of the observation group was 88.10%, which was significantly higher than that of the control group (72.09%), and the difference was statistically significant (P<0.05). After treatment, the pain score, depression score, ESR, TNF-α, CRP, RF, Hcy and cortisol levels in the observation group were lower than those in the control group, while the levels of BDNF, 5-HT and dopamine were higher than those in the control group, with statistical significance (P<0.05). There was no significant difference in the incidence of adverse drug reactions between the two groups (P>0.05). 【Conclusion】Infliximab combined with escitalopram oxalate in the treatment of patients with depression and rheumatoid arthritis can reduce joint inflammation and improve the effect of anti-depression.
林媛媛, 邵体红. 英夫利西单抗联合草酸艾司西酞普兰治疗抑郁症合并类风湿关节炎患者的临床疗效[J]. 医学临床研究, 2025, 42(3): 412-415.
LIN Yuanyuan, SHAO Tihong. Clinical Efficacy of Infliximab Combined with Escitalopram Oxalate in the Treatment of Patients with Depression and Rheumatoid Arthritis. JOURNAL OF CLINICAL RESEARCH, 2025, 42(3): 412-415.
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2025, Vol. 42 
