Abstract：【Objective】To explore the application effect and influencing factors of statins in the secondary prevention of ischemic cerebrovascular disease (ICVD).【Methods】A total of 109 ICVD patients treated in our hospital were followed up for one year. One patient died, and two were lost to follow-up. Patients were divided into a recurrence group and a non-recurrence group based on whether ICVD recurred. Univariate analysis was used to compare the clinical data of the two groups and to explore the factors affecting the preventive effect of statins. 【Results】Among the 106 patients, 15 cases (14.15%) had ICVD recurrence, while 91 cases (85.85%) did not have recurrence of ICVD. There were no statistically significant differences in age, gender, family history, smoking history, alcohol consumption history, white blood cell count, and blood glucose levels between the recurrence and non-recurrence groups (P>0.05). However, significant differences were found in body mass index (BMI), educational level, medical payment method, number of comorbidities, types of medications taken, and compliance (P<0.05). Multivariate regression analysis showed that high BMI, low educational level, self-payment for medical expenses, a high number of comorbidities, taking multiple types of medications, and low compliance were independent risk factors for recurrence in the secondary prevention of ICVD with statins (P<0.05). 【Conclusion】 The effect of statins in the secondary prevention of ICVD is influenced by factors such as patients' BMI, educational level, medical payment method, comorbidities, types of medications, and compliance. Optimizing secondary prevention requires attention to these related factors.
2024, Vol. 41 
