Abstract:【Objective】To investigate the clinical effect of percutaneous spinal endoscopic translaminar approach in the treatment of lumbar instability with lumbar disc herniation.【Methods】A retrospective analysis was performed on 164 patients with lumbar instability with lumbar disc herniation (group A) who underwent percutaneous spinal endoscopic translaminectomy in our hospital from May 2019 to May 2022, and 97 patients (group B) who underwent routine open surgery in our hospital during the same period. The preoperative and postoperative lumbar pain [visual analogue scale (VAS)], the degree of lumbar dysfunction [Oswestry Disability Index (ODI)], the therapeutic effect and the incidence of complications were compared between the two groups.【Results】There was no significant difference in preoperative VAS and ODI scores between the two groups (P>0.05). VAS scores and ODI scores of back and leg pain 1 d, 1 month and 3 months after surgery and ODI scores of 12 months after surgery between the two groups had statistical significance (P<0.05), while VAS scores of back and leg pain 12 months after surgery had no statistical significance between the two groups (P>0.05). VAS scores and ODI scores in the group A were lower than those in the group B at 1 day, 1 month and 3 months after surgery, and ODI scores at 12 months after surgery. 12 months after operation, the curative effect of the group A was better than that of the group B (P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05).【Conclusion】Compared with conventional open surgery, percutaneous spinal endoscopic translaminar approach for the treatment of patients with lumbar instability and lumbar disc herniation has significant clinical efficacy, can improve the pain degree of patients and lumbar rehabilitation effect, and has good safety.