奥拉西坦联合倍他司汀治疗卒中后眩晕对患者脑血流及血清AngⅡ、PDGF-BB水平的影响

doi:10.3969/j.issn.1671-7171.2024.11.011

摘要
图/表
参考文献
相关文章 (15)

全文: PDF (1272 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要【目的】探讨奥拉西坦联合倍他司汀治疗卒中后眩晕对患者脑血流及血管紧张素Ⅱ(AngⅡ)、血小板衍生生长因子-BB(PDGF-BB)的影响。【方法】78例脑卒中后眩晕患者,随机分为对照组和观察组,每组39例。对照组给予甲磺酸倍他司汀片治疗,观察组在对照组基础上加用奥拉西坦治疗。比较两组患者治疗前后的脑血流量、血清AngⅡ、PDGF-BB水平,眩晕程度眩晕调查问卷(UCLA-DQ)、运动敏感度指数量表(MSQ)评分。【结果】治疗后,两组患者的脑血流量较治疗前显著提升(P<0.05),且观察组高于对照组(P<0.05);AngⅡ、PDGF-BB水平较治疗前均显著下降(P<0.05),且观察组低于对照组(P<0.05)。两组治疗后UCLA-DQ、MSQ评分均较治疗前降低(P<0.05),且观察组各项评分均低于对照组(P<0.05)。【结论】奥拉西坦联合倍他司汀能显著改善卒中后眩晕患者病灶区域的脑血量,降低血清AngⅡ、PDGF-BB水平,改善患者眩晕症状,提高生活质量,值得临床推广应用。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	郑春利
	李朋菊

关键词 ：卒中/并发症, 眩晕/并发症, 倍他司汀/治疗应用, 脑血管循环, 血管紧张素Ⅱ/血液

Abstract：【Objective】To investigate the effects of combined treatment of Oxiracetam with Betahistine on cerebral blood flow and levels of angiotensin Ⅱ(Ang Ⅱ) and platelet-derived growth factor-BB (PDGF-BB) in patients with post-stroke dizziness.【Methods】Seventy-eight patients with post-stroke dizziness were randomly divided into the control group and the observation group, with 39 patients in each group. The control group was treated with betahistine mesylate tablets, while the observation group received additional treatment with xxiracetam in addition to betahistine. The cerebral blood flow, serum levels of Ang Ⅱ and PDGF-BB, dizziness severity (as assessed by the UCLA-DQ), and motion sensitivity (as assessed by the MSQ) were compared between the two groups before and after treatment.【Results】After treatment, both groups showed a significant increase in cerebral blood flow compared to before treatment (P<0.05), with the observation group exhibiting a greater increase than the control group (P<0.05). The levels of Ang Ⅱ and PDGF-BB significantly decreased after treatment in both groups (P<0.05), with lower levels observed in the observation group compared to the control group (P<0.05). The UCLA-DQ and MSQ scores significantly decreased after treatment in both groups (P<0.05), with the observation group showing lower scores than the control group (P<0.05).【Conclusion】The combination of oxiracetam and betahistine significantly improves cerebral blood flow in the affected regions of patients with post-stroke dizziness, reduces serum levels of Ang Ⅱ and PDGF-BB, alleviates dizziness symptoms, and enhances the quality of life. This treatment approach is worthy of clinical promotion and application.

Key words： Stroke/CO Vertigo/CO Betahistine/TU Cerebrovascular Circulation Angiotensin Ⅱ/BL

收稿日期: 2023-10-24

中图分类号:

R743.3

通讯作者: *E-mail:295770220@qq.com

引用本文:

郑春利, 李朋菊. 奥拉西坦联合倍他司汀治疗卒中后眩晕对患者脑血流及血清AngⅡ、PDGF-BB水平的影响[J]. 医学临床研究, 2024, 41(11): 1669-1671.
ZHENG Chunli, LI Pengju. Effects of Oxiracetam Combined with Betahistine on Cerebral Blood Flow and Serum Levels of Ang Ⅱ and PDGF-BB in Patients with Post-Stroke Dizziness. JOURNAL OF CLINICAL RESEARCH, 2024, 41(11): 1669-1671.

链接本文:

http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2024.11.011 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2024/V41/I11/1669

[1] 李刚,沈恒,汪纯,等. 奥拉西坦联合神经节苷脂注射液治疗对重症脑颅损伤患者血清NSE、S100蛋白水平的影响[J].医学临床研究,2019,36(2):338-340.
[2] 叶艳,李媚. 辨证分型联合奥拉西坦治疗眩晕临床观察[J].中国中医药现代远程教育,2021,19(16):138-139.
[3] 杜彦挺,杜光勇,贾喆,等. CT灌注成像评估颅脑损伤的程度及其对ICP探头置入术后脑血流动力学的预测价值[J].医学临床研究,2023,40(1):24-27.
[4] 段晓云,张辰慧,张宏,等. 中风醒脑液联合奥拉西坦治疗老年缺血性脑卒中的临床效果[J].中国老年学杂志,2022,42(11):2618-2621.
[5] 郭莹,杜静. 丁苯酞联合奥拉西坦对脑卒中后认知功能障碍患者炎性因子水平及认知功能的影响[J].反射疗法与康复医学,2022,3(23):147-150.
[6] 梁艳,姜鹏程,赵家龙,等. 血栓通注射液联合倍他司汀治疗对缺血性脑卒中患者血液流变学及血脂水平的影响[J].湖北中医药大学学报,2021,23(4):26-29.
[7] 孙丽燕,李景莉,李亚楠,等. 舒血宁注射液联合倍他司汀对椎-基底动脉供血不足性眩晕症患者椎-基底动脉血流速度和氧化应激的影响[J].现代生物医学进展,2022,22(14):2748-2752.
[8] 纪小美,任攀,刘进财,等. 穴位贴敷、耳穴贴压联合SRM-Ⅳ前庭功能诊疗系统治疗良性阵发性位置性眩晕复位后残余症状临床研究[J].河北中医,2023,45(3):446-449.
[9] 张晓阳. 倍他司汀联合丁苯酞对急性缺血性脑卒中的疗效[J].西藏医药,2021,42(5):82-83.
[10] 刘化飞,唐松林. 奥拉西坦联合倍他司汀对卒中后眩晕患者炎症因子及神经功能的影响[J].脑与神经疾病杂志,2023,31(1):48-52.
[11] 高博,吕涛,唐琴,等. 马来酸桂哌齐特联合甲磺酸倍他司汀对后循环缺血性眩晕患者的治疗效果[J].贵州医科大学学报,2022,47(1):119-124.
[12] 杜柏,胡元会,褚瑜光,等. 冠心病心衰气阴两虚型RAAS激活对心功能及脑血流的影响[J].中西医结合心脑血管病杂志,2016,14(16):1885-1887.
[13] 陆翠燕,潘伟锋,邵妤,等. 脑血康胶囊联合抗血小板治疗缺血性脑卒中的效果及对脑血流量的影响[J].实用临床医药杂志,2020,24(3):40-43.
[14] 郭相锐,高凯华,潘敏. 奥拉西坦对病毒性脑炎患儿脑电图特征和炎症因子水平的影响[J].当代医学,2022,28(9):10-12.