Abstract：【Objective】To explore the changes and clinical significance of serum total antioxidant capacity(T-AOC), catalase(CAT), nitric oxide(NO), and glutathione peroxidase(GSH-Px) levels in patients with schizophrenia(SP) complicated with hospital infection. 【Methods】A total of 114 SP patients(observation group) admitted to our hospital from June 2019 to February 2021 were selected. According to the infection status, the patients were divided into an infected group(n=52) and an uninfected group(n=62). According to the severity of the disease, patients are divided into mild group(n=12), moderate group(n=25), and severe group(n=15). Meanwhile, healthy volunteers who underwent physical examinations at the same time in our hospital were selected as the control group(n=71). A comparative study was conducted on the serum levels of T-AOC, CAT, NO, and GSH-Px in the subjects, and their correlation with the severity of the infection group was analyzed. Receiver Operating Characteristic(ROC) curves were used to analyze their diagnostic value for the occurrence of hospital acquired infections in SP patients. Logistic regression equations were used to analyze the influencing factors of hospital acquired infections in SP.【Results】The white blood cell count, neutrophil count, platelet count, monocyte count, TC, LDL-C, and NO in the observation group were higher than those in the control group, while the lymphocyte count, BDNF, TG, HDL-C, T-AOC, CAT, and GSH-Px levels were lower than those in the control group, with statistical significance(P<0.05). The levels of LDL-C and NO in the infected group were higher than those in the uninfected group, while the levels of BDNF, HDL-C, T-AOC, CAT, and GSH-Px were lower than those in the control group, with statistical significance(P<0.05). Comparison of serum T-AOC, CAT, and GSH Px levels: the severe group<moderate group<mild group, with statistically significant differences(P<0.05); Comparison of serum NO levels: severe group>moderate group>mild group, with a statistically significant difference(P<0.05). Pearson correlation analysis showed that serum levels of T-AOC, CAT, GSH-Px were negatively correlated with the severity of the disease(P<0.01), and serum NO levels were positively correlated with the severity of the disease(P<0.01). Logistic regression equation analysis showed that T-AOC<10.03 U/mL, CAT<5.34 U/mL, NO ≥ 30.31μmol/L, GSH-Px<42.36 U/L were independent risk factors for hospital acquired infections in SP patients(P<0.05). ROC curve analysis showed that the AUC area, sensitivity, and specificity of T-AOC, CAT, GSH-Px, and NO combined detection in diagnosing hospital acquired infections in SP patients were all better than single detection(P<0.05). 【Conclusion】The serum levels of T-AOC, CAT, GSH-Px in patients with hospital acquired pneumonia(SP) decrease, while the serum levels of NO increase, which can serve as biological indicators reflecting the condition and help to timely formulate treatment plans and improve patient prognosis in clinical practice.
周美灵, 吕传阁, 王伟阁. 精神分裂症合并医院感染患者血清T-AOC、CAT、NO、GSH-Px水平变化及临床意义[J]. 医学临床研究, 2024, 41(6): 882-885.
ZHOU Meiling, LYU Chuange, WANG Weige. Changes and Clinical Significance of Serum T-AOC, CAT, NO, GSH-Px Levels in Patients with Schizophrenia Complicated by Hospital Infection. JOURNAL OF CLINICAL RESEARCH, 2024, 41(6): 882-885.
2024, Vol. 41 
