Abstract：【Objective】To investigate the relationship of serum tenascin-C(TNC), blood pressure and blood glucose with diabetic peripheral neuropathy(DPN) and Proliferative diabetic retinopathy(PDR). 【Methods】A total of 122 patients with type 2 diabetes(T2DM) admitted to Liuzhou Red Cross Hospital from June 2021 to June 2022 were selected and divided into group A(patients without DPN, n=75) and group B(patients with DPN, n=47) according to whether they had DPN or not. Group A and group B were further divided two sub-groups according to whether PDR was present. Group A was divided into group A1(patients without PDR, n=23) and group A2(patients with PDR, n=52), and group B was divided into group B1(patients without PDR, n=31) and group B2(patients with PDR, n=16). Serum TNC was detected by enzyme-linked immunoassay(ELISA), Fasting blood glucose(FPG) was measured by Roche biochemical analyzer, and blood pressure was measured in each group. 【Results】There were no significant differences in serum TNC, FPG and systolic pressure(SBP) between group A and group B(all P>0.05). There was significant difference in diastolic pressure(DBP) between group A and group B(P<0.05). There were no significant differences in serum TNC levels, SBP and DBP values between group A1 and group A2,as well as between group B1 and group B2(all P>0.05). There was no significant difference in serum FPG level between group A1 and group A2(P>0.05), but there was significant difference in serum FPG level between B1 and B2 groups(P<0.05). There was no correlation of DPN with TNC, SBP and DBP(P>0.05), but there was a positive correlation between DPN and FPG(P<0.05).【Conclusion】Serum TNC level is not associated with DPN, PDR or DPN with PDR. Patients with DPN had higher blood pressure than those without DPN, and patients with both DPN and PDR had higher FPG than those with DPN and PDR alone. Clinicians should control blood pressure and blood sugar levels in patients with T2DM to reduce the incidence of T2DM complications.Clinicians should pay attention to timely treatment and control of blood pressure and blood sugar in T2DM patients to reduce the occurrence of T2DM complications.
[1] RAMSEY D J, KWAN J T, SHARMA A. Keeping an eye on the diabetic foot: The connection between diabetic eye disease and wound healing in the lower extremity[J].World J Diabetes,2022,13(12):1035-1048.
[2] ZHENG H P, SUN W W, ZHANG Q, et al. Proinflammatory cytokines predict the incidence of diabetic peripheral neuropathy over 5 years in Chinese type 2 diabetes patients: A prospective cohort study [J].Clin Med,2020,31:100649.
[3] ROY S, KERN T S, SONG B, et al. Mechanistic insights into pathological changes in the diabetic retina: implications for targeting diabetic retinopathy [J].Am J Pathol,2017,187(1):9-19.
[4] WANG W M, JI Q H, RAN X W, et al. Prevalence and risk factors of diabetic peripheral neuropathy: A population-based cross-sectional study in China [J].Diabetes Metab Res Rev,2023,39(8):e3702.
[5] CHEN J, JOON LEE H, JAKOVCEVSKI I, et al. The extracellular matrix glycoprotein tenascin-C is beneficial for spinal cord regeneration [J].Mol Ther,2010, 18(10):1769-1777.
[6] REINHARD J,ROLL L, FAISSNER A. Tenascins in retinal and optic nerve neurodegeneration [J].Front Integr Neurosci,2017, 11:30.
[7] ISHIKAWA K, KOHNO R I, MORI K, et al. Increased expression of periostin and tenascin-C in eyes with neovascular glaucoma secondary to PDR [J].Graefes Arch Clin Exp Ophthalmol,2020, 258(3):621-628.
[8] 中华医学会神经病学分会肌电图与临床神经电生理学组,中华医学会神经病学分会神经肌肉病学组. 糖尿病周围神经病诊断和治疗共识 [J].中华神经科杂志, 2013, 46(11): 787-789.
[9] ROY S, BAE E, AMIN S, et al. Extracellular matrix, gap junctions, and retinal vascular homeostasis in diabetic retinopathy[J].Exp Eye Res,2015,133:58-68.
[10] CHAUDHARY S, ZAVERI J, BECKER N. Proliferative diabetic retinopathy(PDR) [J].Dis Mon,2021, 67(5):101140.
[11] BHATTACHARYYA S, MIDWOOD K S, VARGA J. Tenascin-C in fibrosis in multiple organs: Translational implications [J].Semin Cell Dev Biol,2022,128:130-136.
[12] ISHIKAWA K, KOHNO R I, MORI K, et al. Increased expression of periostin and tenascin-C in eyes with neovascular glaucoma secondary to PDR[J].Graefes Arch Clin Exp Ophthalmol,2020, 258(3):621-628.
[13] KOBAYASHI Y, YOSHIDA S, ZHOU Y, et al. Tenascin-C promotes angiogenesis in fibrovascular membranes in eyes with proliferative diabetic retinopathy[J].Mol Vis,2016, 22:436-445.
[14] WALLACE D M, MURPHY-ULLRICH J E, DOWNS J C, et al. The role of matricellular proteins in glaucoma[J].Matrix Biol,2014, 37:174-182.
[15] ZHANG Z H, YU B, GU Y, et al. Fibroblast-derived tenascin-C promotes Schwann cell migration through β1-integrin dependent pathway during peripheral nerve regeneration [J].Glia,2016, 64(3):374-385.
[16] NISHIMURA T, HIRATA H, TSUJII M, et al. Pathomechanism of entrapment neuropathy in diabetic and nondiabetic rats reared in wire cages[J].Histol Histopathol,2008, 23(2):157-166.
[17] ZHANG M, WU J Y, WANG Y M, et al. Associations between blood pressure levels and diabetic retinopathy in patients with diabetes mellitus:a population-based study [J].Heliyon,2023,9(6):e16830.
2024, Vol. 41 
