Abstract：【Objective】 To explore the effects of neoadjuvant radiotherapy and chemotherapy on the expression of nuclear protein (ki-67), integrated membrane glycoprotein (CD44v6), and programmed cell death protein-1 (PD-1)/programmed cell death protein ligand 1 (PD-L1) in postoperative esophageal cancer patients. 【Method】A total of 76 patients with esophageal cancer were randomly divided into an observation group and a control group, with 38 cases in each group. Both groups of patients underwent routine esophageal cancer radical surgery, while the observation group received neoadjuvant chemotherapy before surgery. We compared perioperative indicators, clinical efficacy, postoperative ki-67, CD44v6, PD-1/PD-L1 expression levels, and incidence of complications between two groups of patients. 【Results】There was no statistically significant difference in intraoperative bleeding, surgical time, and pleural fluid volume between the two groups of patients (P>0.05); The length of hospital stay in the observation group was less than that in the control group (P<0.05). The objective effective rate of the observation group patients was 76.32% (29/38), significantly higher than the control group's 52.63% (20/38) (P<0.05). The positive expression rate of ki-67 protein and the levels of CD44v6 and PD-1/PD-L1 in the observation group were lower than those in the control group after surgery (P<0.05). There was no statistically significant difference in the total incidence of complications between the two groups of patients (P>0.05). 【Conclusion】Preoperative neoadjuvant radiotherapy and chemotherapy can effectively improve the clinical efficacy and immune function of esophageal cancer patients, with high safety.
巩想平, 史永铁. 新辅助放化疗对食管癌术后ki-67、CD44v6及PD-1/PD-L1表达的影响[J]. 医学临床研究, 2023, 40(12): 1892-1894.
GONG Xiangping,SHI Yongtie. The Effect of Neoadjuvant Radiotherapy and Chemotherapy on the Expression of ki-67, CD44v6, and PD-1/PD-L1 after Esophageal Cancer Surgery. JOURNAL OF CLINICAL RESEARCH, 2023, 40(12): 1892-1894.
2023, Vol. 40 
