Abstract：【Objective】To investigate the correlation between fetal thymus parameters and gestational age in the third trimester. 【Methods】From January 2022 to January 2023, 200 pregnant women in the third trimester were selected from Northwestern University First Hospital, of which 48 were from 29 to 31 weeks, 43 were from 32 to 34 weeks, 54 were from 35 to 37 weeks, and 55 were from 38 to 40 weeks. All pregnant women underwent two-and three-dimensional ultrasonography to measure the anterior and posterior diameter, transverse diameter, circumference and transverse area of fetal thymus at the section of three vessels and the section of left innominate vein, respectively, and the volume of thymus was measured by three-dimensional volumetric imaging. The diameter, transverse diameter, circumference, transverse area and volume of thymus in different gestational weeks were compared. Pearson correlation coefficient was used to analyze the relationship of gestational age with anterior and posterior diameter, transverse diameter, circumference, transverse area and volume of thymus. 【Results】The anterior and posterior diameter, transverse diameter, circumference and transverse area of thymus measured at the section of the three blood vessels and the section of the left innominate vein at weeks 29 to 31, 32 to 34, 35 to 37 and 38 to 40 increased sequentially, and the differences between groups were statistically significant (P<0.05). The volume of fetal thymus from 29 to 31 weeks, 32 to 34 weeks, 35 to 37 weeks and 38 to 40 weeks increased in sequence, and the differences between groups were statistically significant (P<0.05). Pearson correlation coefficient analysis showed that the anterior and posterior diameter, transverse diameter, circumference, transverse area and volume of thymus were positively correlated with gestational age (P<0.05). 【Conclusion】The anteroposterior diameter, transverse diameter, circumference, transverse area and volume of thymus increased with the increase of gestational weeks, and the anteroposterior diameter, transverse diameter, circumference, transverse area and volume of thymus were positively correlated with gestational week.
[1] KESHAVARZ E, SHEIKHYUSEFI M R, POUYA E K,et al. Association between fetal thymus size and intrauterine growth restriction[J].J Diagn Med Sonogr,2022,38(2):120-126. [2] VAN DER VEEKEN L, RUSSO F M, LITWINSKA E, et al.Prenatal cerebellar growth is altered in congenital diaphragmatic hernia on ultrasound[J].Prenat Diagn,2022,42(3):330-337. [3] NAU T G, DE MURCIA K O, MÖLLERS M, et al. Foetal thymus size in pregnancies after assisted reproductive technologies[J].Arch Gynecol Obstet,2018,298(2):329-336. [4] 杨田,吉翔,牛建梅,等.二维超声在产前胎儿胸腺发育评估中的应用[J].诊断学理论与实践,2021,20(5):471-474. [5] THAPA P, FARBER D L. The role of the thymus in the immune response[J].Thorac Surg Clin,2019,29(2):123-131. [6] 赵刘碧琦,杨瑞琦,范丽梅,等.母体先兆子痫时胎儿胸腺的三维超声体积测量[J].中国妇幼保健,2018,33(24):5997-5999. [7] 娄丽平,王华,张灵巧.三血管气管切面在筛查胎儿心脏大血管异常中的临床应用价值[J].中国临床医学影像杂志,2022,33(10):721-723. [8] 黄羽君,朱云晓,林冬梅,等.四腔心与三血管气管切面联合HD-flow筛查早孕期胎儿心血管畸形的应用价值[J].中山大学学报(医学科学版),2022,43(1):146-151. [9] 顾凯莉,田力,冯涛,等.产前超声于左无名静脉切面测量孕20～38周胎儿胸腺参数[J].中国医学影像技术,2022,38(6):893-896. [10] 李霞,张兰珍,路妍妍,等.二维超声联合三维成像在胎儿唇腭裂的应用分析[J].中国超声医学杂志,2018,34(3):253-256. [11] 杨瑞琦,郭凤军,刘学娟,等.二维和三维超声测量胎儿胸腺在胎儿宫内生长迟缓时的应用[J].中华医学杂志,2014,94(33):2607-2609. [12] 陈群群,赵雅萍,阮如慧,等.三维容积超声成像评估胎儿胸腺发育的研究[J].中国超声医学杂志,2018,34(10):919-921. [13] 王咏梅,吴云,曹荔,等.产前二维及三维超声测量正常胎儿胸腺[J].中国介入影像与治疗学, 2017, 14(1):31-34.
2023, Vol. 40 
