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医学临床研究  2023, Vol. 40 Issue (12): 1857-1860    DOI: 10.3969/j.issn.1671-7171.2023.12.010
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癫痫患者MoCA评分与血清PKC、IGF-1及BNDF的关系
杜爱敏1, 拓珍1, 孙莎1, 樊琼2*
1.西安高新医院神经内科,陕西 西安 710000;
2.高陵区医院神经内科,陕西 西安 710200
Relationship of MoCA Score with Serum Levels of PKC, IGF-1, and BNDF in Epilepsy Patients
DU Aimin, TUO Zhen, SUN Sha, et al
Department of Neurology, Xi'an High-Tech Hospital, Xi'an Shaanxi 710000
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摘要 【目的】探讨癫痫患者蒙特利尔认知评估量表(MoCA)评分与血清蛋白激酶C(PKC)、胰岛素样生长因子-1(IGF-1)、脑源性神经营养因子(BNDF)水平的关系。【方法】在两院接受治疗的80例癫痫患者,依据MoCA评分情况分为认知功能障碍组(A组,评分<26分)和非认知功能障碍组(B组,评分≥26分)。比较两组患者的基础资料、脑电图结果及血清指标[PKC、IGF-1、BNDF、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]。通过受试者工作特征(ROC)曲线分析血清PKC、IGF-1、BNDF水平与癫痫伴认知功能障碍的关系,通过多因素Logistic回归分析癫痫患者认知功能障碍的危险因素。【结果】80例患者中52例(65.00%)存在认知功能障碍,归为A组,28例(35.00%)无认知功能障碍者归为B组。A组中全面性发作、脑电图癫痫样波人数占比高于B组,A组PKC、IGF-1、BNDF水平均低于B组(P<0.05),两组年龄、性别、病程、癫痫家族史、高热惊厥史、IL-6、TNF-α水平等比较,差异均无统计学意义(P>0.05);经ROC曲线分析证实,PKC、IGF-1、BNDF水平能用于认知功能障碍的预测,曲线下面积分别为0.927、0.732、0.862(均P<0.05);多因素Logistic回归分析显示,全面性发作、脑电图癫痫样波、PKC<3.015 pg/mL、IGF-1<126.57 μg/L、BNDF<7.635 μg/L是认知功能障碍的危险因素(P<0.05)。【结论】癫痫患者MoCA量表评分与血清PKC、IGF-1及BNDF水平呈正相关,癫痫全面性发作、脑电图癫痫样波、PKC<3.015 pg/mL、IGF-1<126.57 μg/L、BNDF<7.635 μg/L均为癫痫患者认知功能障碍的危险因素,需引起临床重视。
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杜爱敏
拓珍
孙莎
樊琼
关键词 癫痫蛋白激酶C/血液胰岛素样生长因子Ⅰ/血液脑源性神经营养因子/血液    
Abstract:【Objective】To explore the relationship of Montreal Cognitive Assessment (MoCA) score with serum levels of protein kinase C (PKC), insulin-like growth factor-1 (IGF-1), and brain-derived neurotrophic factor (BNDF) in epilepsy patients. 【Methods】Based on the MoCA scores, 80 epilepsy patients treated in our hospitals were divided into the cognitive impairment group (group A with MoCA score <26) and the non-cognitive impairment group (Group B with MoCA score ≥26). The basic information, electroencephalogram results, and serum indicators [PKC, IGF-1, BNDF, Interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α)] of the two groups were compared. The relationship of cognitive impairment with serum PKC, IGF-1, and BNDF levels was analyzed using Receiver Operating Characteristic (ROC) curve analysis. Multivariate Logistic regression analysis was used to identify the risk factors for cognitive impairment in epilepsy patients. 【Results】Among the 80 patients, 52 (65.00%) cases had cognitive impairment and were categorized into the group A, while 28 (35.00%) cases did not have cognitive impairment and were categorized into the group B. The proportion of patients with generalized seizures and epileptiform waves on electroencephalogram in Group A was higher than that in Group B. The levels of PKC, IGF-1, and BNDF in Group A were lower than in Group B (P<0.05). There were no significant differences in age, gender, duration of illness, family history of epilepsy, history of febrile seizures, IL-6, and TNF-α levels between the two groups (P>0.05). ROC analysis confirmed that the levels of PKC, IGF-1, and BNDF could be used to predict cognitive impairment, with area under the curve (AUC) values of 0.927, 0.732, and 0.862, respectively (all P<0.05). Multivariate Logistic regression analysis showed that generalized seizures, epileptiform waves on electroencephalogram, PKC<3.015 pg/mL, IGF-1<126.57 μg/L, and BNDF<7.635 μg/L were risk factors for cognitive impairment (P<0.05). 【Conclusion】MoCA scores in epilepsy patients are positively correlated with serum levels of PKC, IGF-1, and BNDF. Lower scores of MoCA indicate more severe cognitive impairment and lower serum levels of PKC, IGF-1 and BNDF. Generalized seizures, epileptiform waves on electroencephalogram, PKC<3.015 pg/mL, IGF-1<126.57 μg/L, and BNDF<7.635 μg/L are all risk factors for cognitive impairment in epilepsy patients, which should be given clinical attention.
Key wordsEpilepsy    Protein Kinase C/BL    Insulin-Like Growth Factor Ⅰ/BL    Brain-Derived Neurotrophic Factor/BL
收稿日期: 2022-09-23     
中图分类号:  R742.1  
通讯作者: *E-mail:15229085832@163.com   
引用本文:   
杜爱敏, 拓珍, 孙莎, 樊琼. 癫痫患者MoCA评分与血清PKC、IGF-1及BNDF的关系[J]. 医学临床研究, 2023, 40(12): 1857-1860.
DU Aimin,TUO Zhen,SUN Sha,et al. Relationship of MoCA Score with Serum Levels of PKC, IGF-1, and BNDF in Epilepsy Patients. JOURNAL OF CLINICAL RESEARCH, 2023, 40(12): 1857-1860.
链接本文:  
http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2023.12.010     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2023/V40/I12/1857
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