Abstract：Objective To analyze the risk factors of post-stroke epilepsy and the electroencephalogram (EEG) of the patients. Methods A total of 1,396 stroke patients admitted to our hospital from September 2011 to September 2017 were selected as the study subjects, and 951 stroke patients were included in the study. According to whether epilepsy occurs after stroke, they were divided into epilepsy seizure group and non-epilepsy seizure group. The risk factors of epileptic seizures after stroke were analyzed and the EEG manifestations of the patients were observed. Results In this study, the incidence of epileptic seizures after stroke was 5.68%, of which early-onset epilepsy accounted for 55.56%, late-onset epilepsy accounted for 44.44%. Disseminated abnormalities in EEG and localized abnormalities were found in 25.93% and 48.15% of patients with epileptic seizures after stroke. Multivariate regression analysis showed that the location, extent, hyperhomocysteinemia and NIHSS score (≥25) were independent risk factors for epileptic seizures after stroke.Conclusion Patients with stroke in the cortex, large extent of lesions, hyperhomocysteinemia, and NIHSS score ≥25 should be highly alert to seizures.
[1] Bots SH, Peters SAE, Woodward M. Sex differences in coronary heart disease and stroke mortality: a global assessment of the effect of ageing between 1980 and 2010[J]. BMJ Glob Health,2017,2(2): e000298. [2] Tanaka T, Ihara M. Post -stroke epilepsy[J]. Neurochem Int,2017,107(7):219 -228. [3] Hansen J, Asberg S, Kumlien E, et al. Cause of death in patients with poststroke epilepsy : Results from a nationwide cohort study[J].PLoS One,2017,12(4): e0174659. [4] 中华医学会神经病学分会脑血管病学组急性缺血性脑卒中诊治指南撰写组.中国急性缺血性脑卒中诊治指南2010[J].中华神经科杂志,2010,43(2):146-153. [5] Khealani BA, Ali S, Baig SM. Post stroke seizures: descriptive study from a tertiary care centre in Pakistan[J]. J Pak Med Assoc, 2008,58(7):365-368. [6] Jungehulsing GJ, Heuschmann PU, Holtkamp M,et al. Incidence and predictors of post-stroke epilepsy[J]. Acta Neurol Scand,2013,127(6):427-430. [7] Zou S, Wu X, Zhu B, et al. The pooled incidence of post-stroke seizure in 102 008 patients[J]. Top Stroke Rehabil,2015 ,22(6):460-467. [8] Kirillovskikh ON, Miakotnykh VS, Sorokova EV,et al. Features of bioelectric activity of the brain in epilepsy patients of elderly and senile age[J]. Adv Gerontol,2011,24(3):426-432. [9] Mecarelli O, Pro S, Randi F,et al. EEG patterns and epileptic seizures in acute phase stroke[J]. Cerebrovasc Dis,2011,31(2):191-198. [10] Henning O, Baftiu A, Johannessen SI,et al. Withdrawal of antiepileptic drugs during presurgical video-EEG monitoring: an observational study for evaluation of current practice at a referral center for epilepsy[J]. Acta Neurol Scand,2014,129(4):243-251. [11] 晏玉奎,王庄.影响癫痫患者预后因素的研究进展[J].中华医学杂志,2015,95(15):1196-1198. [12] 黄亮,俞丹,罗蓉.儿童病毒性脑炎急性期临床病理特征对继发癫痫的影响[J].四川大学学报(医学版),2017,48(2):257-262. [13] Kim JH, Lee HW, Cohen LG, et al. Motor cortical excitability in patients with poststroke epilepsy[J]. Epilepsia,2008 ,49(1):117-124. [14] 刘万平,廖科.症状性癫痫的病因学分析及有关癫痫形成时间的研究[J].医学临床研究,2014,31(5):924-928. [15] 徐菲,金平,王玉.脑卒中后癫痫发作的相关危险因素分析[J].中华疾病控制杂志,2017, 21(2):179-182. [16] 郑燕学,陈锡阳,梁世福,等.奥卡西平治疗过程中MHD血药浓度变化与患者临床效果及安全性分析[J].湖南师范大学学报(医学版),2017,14(5):66-69.
2019, Vol. 36 
